<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33869

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMCACDFAPGAPLQGYEYPDTVSTAKIESIDHTKVEEAAVSAPQGGGGLVGEQGRETMPSVFMDSGSRNGSHTNHDRDRHSNGTNVEARASEKGRDKMQARPEPQQNMTPTSPAMPNGMNGNFMDGSARQQNPMEEPIPQDILDHIHDLPPEVEHITANFISLTELLNRLAQSTHNDLRRAITELADMPVPQSAINGSSYHTAREDDTSNDNVKKKVSLIEFAQTQHATWVKQLVILDWSRKADEVSKIIDLSVHLIHQRELYNGILGCLGQMKRGLLDLDVPNPDLKTAVEVLSTGKANWMPDLGYIVPPPMTPKDLLKSLLTIDTLLSIRLNLYEYDKIPPQFKGYTIKSGRVTFKVPGEFEIDLTIADEDQESQFWFIDFRFLFSPSPSRLSPRHQYHIESKVNTALEKDGLSGCYTYLHEMVLTHKISEFRRQAVELSRSTWIDGVKVEPLNRALCIQYWQDRYKKNGPRSWIIIGVHSGRRKDGYHDPRTTSRLFIRWFRDSKEVTDADIPFDKVNISPEQLLKTVIAMHVNHILSSTYSKLAVKPIFANREAVLSLHTSKTEPKESALGVQLTERQHIQITIEPVTGFFIFSPASRTITSSQNKLNSLDIDPAMDAHLGIETLRCLAISEELIILGTSVGWRRADNPGISREDMKRKVPKDTKQITWFRRPGWQEDWLVAVTLGLSGEAWWLFQISKQPTGAKVLTSIHIPIKAVSPTPSYVFMSTLHIFAGGLISQYTNLKALHDRRIRHTIRQASPPSAVKLPSIWIHISELLQARAKPSAPKTWAKDFLKLTFQGLEPFFALPSLPSQALVDGSQPIRPELEQKAVIVTVARMTVPIPALSVLNEKIDEDIVFQAKTGEIAFRLRSQVGESIIPALSDRLFQVERLISCTAVLRKHEKAIKCDTITLQEIAFSYGMPPVSEAGLAMGAGKTAPLLYKAVVSFGLVEDKMKLTLETGNPHIRVLDALDKILNIAKGGFDAVATLLPQTLYPLRAFETIEDAWASLHNKGEVFVFVRAFEWFSLRYVLKPSTSNMPSRTVSFDIKMCHRKHKPWWLIRRTEKTDKGGKGEVLPDDEIDARLRSIWDFPGDDDWKGMRTSAVGCDRGVETCLEKVDLVMRGLSQKDLVVQPSQHSQIRMQAQAVGPQGQQTSHPQQQRQLQIPTQAHSQNYQQIQGSSQGQQRMPTPNMNINLNIKQNTLKRRSSNQSINPRPAKREVVEID
Length1227
PositionTail
OrganismSclerotinia borealis (strain F-4128)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Sclerotiniaceae> Sclerotinia.
Aromaticity0.07
Grand average of hydropathy-0.391
Instability index51.81
Isoelectric point8.55
Molecular weight137940.12
Publications
PubMed=24459262

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP33869
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     112.11|      30|      30|    1136|    1165|       1
---------------------------------------------------------------------------
 1094- 1119 (32.14/15.77)	........PGD.DDWKGMRTSAVGcDRGVETCLEK
 1128- 1160 (51.23/29.54)	SQKDLvvqPSQ.HSQIRMQAQAVG.PQGQQTSHPQ
 1161- 1187 (28.73/13.31)	QQRQL.qiPTQaHSQNYQQIQG.S.SQGQQ.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     168.58|      38|      38|      67|     104|       3
---------------------------------------------------------------------------
   31-   70 (54.82/36.75)	HTKVEEAAVSAPQGGGGLVGEQGRETMPSvfMDSGSRNGS
   71-  108 (64.89/45.04)	HTNHDRDRHSNGTNVEARASEKGRDKMQA..RPEPQQNMT
  109-  139 (48.87/31.85)	PTSPAMPNGMNGNFMDGSARQQ..NPME...EPIPQ....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.68|      37|      38|     703|     740|       4
---------------------------------------------------------------------------
  703-  740 (61.23/38.65)	QPTGAKVL..TSIHIPIKAVSPtPSYVFMSTLHIFAGGLI
  742-  780 (60.44/34.00)	QYTNLKALhdRRIRHTIRQASP.PSAVKLPSIWIHISELL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.25|      12|      25|     644|     658|       7
---------------------------------------------------------------------------
  644-  658 (15.99/16.33)	VGWRRadNPGiSRED
  670-  681 (27.26/13.96)	ITWFR..RPG.WQED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.22|      18|      37|     447|     465|       8
---------------------------------------------------------------------------
  447-  465 (30.65/28.57)	DGVKvEPLNRA.LCIQYWQD
  487-  505 (31.56/23.42)	DGYH.DPRTTSrLFIRWFRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.78|      32|     208|     359|     426|       9
---------------------------------------------------------------------------
  384-  416 (51.33/56.32)	FLFSPSpSRLSPRHQYHIES.KVNTALEKD.GLSG
  594-  627 (45.45/10.66)	FIFSPA.SRTITSSQNKLNSlDIDPAMDAHlGIET
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33869 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DLRRAITELADMPVPQSAINGSSYHTAREDDTSND
2) LQGYEYPDTVSTAKIESIDHTKVEEAAVSAPQGGGGLVGEQGRETMPSVFMDSGSRNGSHTNHDRDRHSNGTNVEARASEKGRDKMQARPEPQQNMTPTSPAMPNGMNGNFMDGSARQQNPMEEPIPQDILDHIHDLPP
3) SQKDLVVQPSQHSQIRMQAQAVGPQGQQTSHPQQQRQLQIPTQAHSQNYQQIQGSSQGQQRMPTPNMNINLNIKQNTLKRRSSNQSINPRPAKREVVEID
176
12
1128
210
150
1227










Molecular Recognition Features






MoRF SequenceStartStop




NANANA