<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33864

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMEDVDNMDVDMDDLFGDGTGLSLPSRPPSKELHQRIDELRGSGCCQGIAWSKWGSIASITPSGTGLELRNLRCHPENGTWGLSEPTIIPQLTNNLDGGPLKHLSWSPTGSELAVIDSAGRVTILQIFSSLNKPMMCRPCSPDSADDLHAVVGCFWLNLGPFQNRPVIQHGPAFKEASGIRYDSSQTPILGPTHPIHSKSALLYVTTNGSLRLLWPQNNGKWFESITELESIVSSDDLITHAAISAERTPSLLIALATGSKQLRIIRAGVDWGIPQTQEKVNPMTILLNASLRIKPLTVTSWLHDVPGDTINSSHLESSMVQLSHLEFLSPSGDNKNIMTPPILVAVRPYLPGSTSHYNQEAHSTIDRWEFRERNQQPVHSAFEHLSSRKSSTNDSQPPKPVVIAQLKKLESFTVNKIVVAMQTIYLGKIVCFAYSDSSVEYRDRITMNETFNDGDLGRVSHLSQIGFSYTEDEPCLQVAWSPSTCSLVQIRNDGKVKWKQLDYHLGDIGSNMEDPRYTAMIAALSLSCSTSVMMSTNYDDIVATAHNLAKSRDNLAYDWLNELAKILKIIVDYSEEAHYDVLIRNTTIQLCLSIQNSLGFRGDFNPRKFAGKFSWLVLQLRNIVVLVTMAANMKVPGPTHEKTSTPLDDPEVISALAGSVRWVLDLMAWITDTLLELPSTLPFNLSVTNPSKLSLPDLLTYLHTTNNVSLHLLLSSPTRGFLTAICRRLLHLDYVARKAIDTGTNAQIQPGGSGQQSVSPALRAAYLQIANLTNNCIVRIRTFENLLTSLTSSIKSAYANHKPPLSGNNPMGASRNNLEIKMLFGGEIPTAFKPVIIELFAGVQDNEKNGHNTATGANGGIGYLSSVRLEIDPANLWFADFTMLEVDEDEESITKRRNSRLTMDCFRKTWLNNPPKISQSSSANKLLGDGRDKDNNVNSLLTSTGPGPGITGSAYGIAAPGSTAAARRWRRCARCAAVMEDVLSQRPALQWLVMQQRRCFCSGYWDTLVGGEMVA
Length1015
PositionTail
OrganismSclerotinia borealis (strain F-4128)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Sclerotiniaceae> Sclerotinia.
Aromaticity0.07
Grand average of hydropathy-0.209
Instability index38.76
Isoelectric point6.35
Molecular weight111703.80
Publications
PubMed=24459262

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats
>MDP33864
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.23|      21|      54|      34|      63|       1
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   34-   55 (38.85/20.52)	QRIDELRGsGCCQGIAWSKWGS
   90-  110 (40.37/22.14)	QLTNNLDG.GPLKHLSWSPTGS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     228.44|      72|     398|     239|     398|       2
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  321-  397 (113.31/180.55)	QLSHLEFLS....PSGDNKNIMtpPILVAVRPYLPGSTSHYNQEAHSTiDRWEFRERNQQPVHSAFehLSSRKSSTNDSQP
  728-  803 (115.14/43.99)	RLLHLDYVArkaiDTGTNAQIQ..PGGSGQQSVSPALRAAYLQIANLT.NNCIVRIRTFENLLTSL..TSSIKSAYANHKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.92|      23|     398|     239|     271|       3
---------------------------------------------------------------------------
  192-  214 (42.55/26.71)	THPIHS...KSALLYVTTNGS..LRLL.....W
  239-  271 (24.37/39.00)	THAAISaerTPSLLIALATGSkqLRIIragvdW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     188.21|      61|     307|     554|     678|       4
---------------------------------------------------------------------------
  485-  553 (97.48/113.29)	CSLVQ....IRND.......GKVKWkqLDYHLGDIgsnmedPRYTAMIAALSLSCSTSVMMSTNYDD...IVATAHNLAKSRD
  591-  665 (90.72/96.22)	CLSIQnslgFRGDfnprkfaGKFSW..LVLQLRNI......VVLVTMAANMKVPGPTHEKTSTPLDDpevISALAGSVRWVLD
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.29|      17|     827|      69|      88|      11
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   69-   88 (26.03/21.67)	RNLR....CHPEngTWgLSEPTII
  897-  917 (30.26/13.96)	RNSRltmdCFRK..TW.LNNPPKI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33864 with Med16 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DNMDVDMDDLFGDGTGLSLPSRPPSKELHQRI
5
36










Molecular Recognition Features






MoRF SequenceStartStop




NANANA