Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDKIIDARFDRVEKALASLIASISKYNPVPALAQDLVLADQELNDGLSLLNQHQHNTYKLTTLHATSAALDTQVREFTLLLNSTRSELLNTSSSEYPEDKNLVEYEELLSYARKISKFTVPPEARLSKLEDTSSKQDGVATNGSTTPNVTVMGNGANGTSMDLDISSITPSNGTTSLAPSQDPVSQQPSQTQTALDAETTRLLNTGFDLRPFVPWAREDDIKMGALASLQVLVDSGIDPEGWDPEIEEQKKREKVEEAEREAEAERMQEEEKRRLEMERRNNAMSGVQGGTAAERPKVFQLDEFDDDDD |
Length | 309 |
Position | Middle |
Organism | Sclerotinia borealis (strain F-4128) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Sclerotiniaceae> Sclerotinia. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.685 |
Instability index | 45.28 |
Isoelectric point | 4.49 |
Molecular weight | 34233.39 |
Publications | PubMed=24459262 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP33863 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 48.51| 14| 17| 164| 177| 2 --------------------------------------------------------------------------- 164- 177 (24.63/14.62) DISSITPSNGTTSL 182- 195 (23.88/13.97) DPVSQQPSQTQTAL --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 35.92| 11| 17| 67| 77| 3 --------------------------------------------------------------------------- 67- 77 (17.99/10.50) SAALDTQVREF 86- 96 (17.93/10.45) SELLNTSSSEY --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) MSGVQGGTAAERPKVFQLDEFDDDDD 2) RRLEMERRNN | 284 273 | 309 282 |
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