<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33860

Description Uncharacterized protein
SequenceMTTKPLVGSQTQRQSQRSLNSNITSRPSPQRSLSSTSPTRRHNEALIDLTLDVPDPTSVRYGQTSRAGGSRLKQEISNESRGSIQAEATSSASSNAISNRQYLSPRGRPQLHSDVLRSKASKSSLTPDQHFNQTSAKPFPLPVRPGQHAPPFVEKPGSSIGSSGKKDARPKPYVLEVPTAAPYSPNGHADFFPWNGNHSEDQFSEPVIRQGFFDKSQMSQNETGSAKASIYPSLKHKSGLQTLSSLFSNVLAQRRAHGNITANSTFKPPPRVTVTDTKREIWLKDLANPTISLRRLSRSIPHGIRGRVLLEHSLNKNIPIERAVWLAKCVGANELRSFKRKGAGGTFAMGGEAKWVRDFTVCVEQVMESIIGSCGEKDFRRRTCYAIRLAAHFHAECLIDREHYIDWILSSLEATSQPKLPIWLLIAQVYWEDILRYRRFGRRLTATLLNQFSEVIRHPDADILRPLNDRLRLLLHELMMSNPDNFVCPETWSKHREILQAHLNYSDELPTTVWDDINRRNIRLTTLAPDAQHPPRQRLIDILDKTLFTLFTPEVIDICWQLDADKPTLIHAVLDWSTSCYRPGNAKVFIGARIMRSWRRLGTDGTASILSFLDSSACEIGRNKSSFYHLVSELARSNDFCIPTYLQWLISRGGIHGHSDLAPDGPCGTRLLAELPIHDLSGEMVALRRTLLCRAEYPIEIEDHKMTASISTISNLLLLAASEPRLTQVNRRVKGLHDLRSLARASKSHIGFWLRREVELQVLPSSTALNKWDVLHSSREASVLTAVAFGILRDSLETIDDFSMLADVIRIATASTDSQVIVSCADTLNMHAEIFAAIGAIKNLFDVLLGRARSLADDRDIVPRVMLVSLLDLSSRIPENQSITAQLARQLALSDRKCVAEACSPVSDHMAAASQNNEVEFIDEIEKLLANGTSIDRGTMERIFQRLAHHLSVSWDKSVDQQRKCVLLLTTLRDFNPKPFDLLMASWLSHIPKLEHRPSMVKICGPLIGLGCLSMKDLVNACLDTGKAEFNSPRKLGMIVAMELLSLLTTPVLAPEILTSDEAYHIRLLQTRMHIENPELTLTVIRSAIEACSTVARDMPSIALHTLDVLGGSVMHDLLQTLVLIGGDITSKILVLPLSHGSTDEEAFKLIATAINKLLVPTYQTESSNISVGDALKFANYLNLPFCQLKVASTFHSGKPSQSNSWNMVSPQLDDLNRAVESAIKAGGTTWACIVPSLDFTAIHHLRRGAEAQLLALFHTAKASGYNDILEEEHQLTKAESLLVILDLTIDKTHTEKASVSNTSPNCFPDIVILLSGVSQYIANTQNTGCKVTFLTKWLPLLLSFTTSQAIALEQSKAGHEHRGRAILSLTTILLDLYVLKANTEIQYLPLEQCFDLVLNMVDVIPDDIRQQCGRNFREAASNLIISYIYSIIAAPSDWLYIYQGGILKSAAAGRHSSNTNTDHNKEPSRQLFPFTMKRWEMLGEPTPNMGENDTSLSLTLFASRKGVS
Length1509
PositionKinase
OrganismSclerotinia borealis (strain F-4128)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Sclerotiniaceae> Sclerotinia.
Aromaticity0.06
Grand average of hydropathy-0.187
Instability index49.61
Isoelectric point8.39
Molecular weight167791.07
Publications
PubMed=24459262

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33860
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     219.99|      73|      86|    1260|    1345|       1
---------------------------------------------------------------------------
 1260- 1345 (98.38/107.53)	TAKAsGYndileeEHQLTKAESL.LVILDLTIDKTHTEKASVSntSPNCFpDIVILLSGVsqyIANTQNTGCKVTFLTKWLPLLLSF
 1355- 1428 (121.60/86.92)	QSKA.GH......EHRGRAILSLtTILLDLYVLKANTEIQYLP..LEQCF.DLVLNMVDV...IPDDIRQQCGRNFREAASNLIISY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.39|      10|      82|      54|      63|       2
---------------------------------------------------------------------------
   54-   63 (21.18/13.64)	PDPTSVRYGQ
  138-  147 (22.21/14.73)	PFPLPVRPGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     160.99|      51|      82|     634|     715|       4
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  634-  689 (80.83/98.84)	LARSNdfciPTYLQWLISRGGIHGHSDL..APDGPCGTRLLAELPIHDLSGEmVALRR
  719-  771 (80.17/38.61)	LAASE....PRLTQVNRRVKGLHDLRSLarASKSHIGFWLRREVELQVLPSS.TALNK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.74|      35|     210|     158|     194|       6
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  158-  194 (62.39/55.54)	SSIGSSGKKDARPKP.YVLEVptAAPYSPNGHAD...FFPW
  369-  407 (57.35/42.75)	SIIGSCGEKDFRRRTcYAIRL..AAHFHAECLIDrehYIDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.67|      40|     657|     298|     350|       7
---------------------------------------------------------------------------
  301-  346 (61.14/67.68)	PHGIrgRVLLEHSLNKNIPIERAVWlakcVGANELRSFKRKGAGGT
  567-  606 (75.54/42.44)	PTLI..HAVLDWSTSCYRPGNAKVF....IGARIMRSWRRLGTDGT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33860 with Med12 domain of Kingdom Fungi
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