<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33852

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDSRAAAAEGMRSAIEYWSQFVARSISHRLDTEKFENYVRLVHDQHPLPPALVADFFLRPQPSNDNSLDPRIPPYLQVLTRLGYVDAPSILKALYKYSSLHAYAQQPNANEGKDKEKENEKSDDKEKDEKKQKITRWKSSYWAEEVLFYGITKSVVEGKAIRDSKTALEMTRIISKLMVLFTTAFAADMIEQLHTTQVRDEMESSRAALVALLLRMCENDILVGAVSKPIAKDVRKEMSAGLASFVPTLQLVPQITDKLEQFRTEILASSDPADKKKQATNAAMDELLDSAVGLDNFVVADIPISNTRTGLYIYLNAALIARPLLDDHALFSYMSNKYQGDIQSSAIDLILASFDILANAVFRNEGQKDAHLLRSFLINKVPILLYQLLPPGFPGTSAEFCITEALSHVDTSLFPTASLMFDESRNNNPYTESVREEFCAACVLHGLVQREHVERILGEISLSYEPSLQKHSKDKLVQDCLSDTEKIQGLVRELDKMDGNVGAVCQALVEVLRQSCHNKETMSLKVLCSQLAAKPQSLDVILLFEKLPNILEPLCQLLDNWRYEDDQEEYQPVYEEFGAVLLLVLAFTYRYNLNAVEIGIASPDSWVARIIGRGHIGRQCNELTQRENDHLNGWIHGLFDTEAGGLGDELMSSCPPQEFYLVVAPLFQSIVVAYTHGYLNDESLKGGIEYLVDTFLLPSLVPAIRFLADYLWIDQKEQKSIIKILQLILLPSSISGEASTMLSSVKNLIAKPLEHALRTYQRRDPNNQDIEPLLRTLKDSIPLSRRTGGTDLNELESWTTTLPTGLSSAIKLTIQGLVHWSIHPAMNSMPTSYTHRQILAALKIMGPKRVLHVILEEIRQHTEAGSASIVYDVAISLICAPDAAKDAPAVVDANGNMLPPVQRQRSLRDLLKVEAEGCRKLQKKDPALAEIVVRLHRRVEAQMIIPQPPGMLQTAEMSLNLDGDTAGLGDAMAAAASGVQGDNMSVDNLTLDVSMGGVPSDLGLGSANDGGSLDPSGDAAMFEGFDTQDMDNFDWDDISNSFQ
Length1043
PositionTail
OrganismGibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium fujikuroi species complex.
Aromaticity0.07
Grand average of hydropathy-0.171
Instability index44.06
Isoelectric point5.04
Molecular weight115785.78
Publications
PubMed=20237561

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33852
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.22|      31|      40|     399|     438|       1
---------------------------------------------------------------------------
  404-  438 (45.33/50.86)	EALSHVdtsLFPTASLMfDESRNNNPYTE..SVREEF
  545-  577 (53.89/30.68)	EKLPNI...LEPLCQLL.DNWRYEDDQEEyqPVYEEF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     289.55|      83|     147|     593|     680|       3
---------------------------------------------------------------------------
  593-  676 (144.70/87.80)	LNAVEIGIASP...........DSWVARIIGRGH.......IGRQCNELTQRENDH..............LNGWIHGLFDTEAGGLGDELMSSCPPQeFYLVVAPLFQSIVVAYTH
  742-  835 (101.87/55.81)	LSSVKNLIAKPlehalrtyqrrDPNNQDI.................EPLLRTLKDSiplsrrtggtdlneLESWTTTL....PTGLSSAIKLTIQGL.VHWSIHPAMNSMPTSYTH
  925-  972 (42.97/19.60)	......................DPALAEIVVRLHrrveaqmIIPQPPGMLQTAEMS..............LN......LDGDTAGLGDAM..........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      69.69|      17|      34|     197|     213|       4
---------------------------------------------------------------------------
  197-  213 (27.20/20.04)	QVRDEMESSRAALVALL
  233-  249 (25.89/18.68)	DVRKEMSAGLASFVPTL
  254-  268 (16.61/ 8.98)	QITDKLEQFRTEILA..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.76|      22|      34|     678|     699|       5
---------------------------------------------------------------------------
  678-  699 (38.03/28.31)	YL.NDESLKGGIEYLVDTFLLPS
  710-  732 (31.73/22.30)	YLwIDQKEQKSIIKILQLILLPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.66|      12|      41|     326|     337|       8
---------------------------------------------------------------------------
  326-  337 (23.25/17.11)	DDHALFSYMSNK
  369-  380 (21.41/15.11)	DAHLLRSFLINK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.74|      19|      34|     476|     494|       9
---------------------------------------------------------------------------
  476-  494 (31.42/22.70)	LVQDCLS.DTEKIQGLVREL
  512-  531 (29.31/20.65)	LRQSCHNkETMSLKVLCSQL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33852 with Med5 domain of Kingdom Fungi
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