<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33849

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMDKYIDGRFERLEKALANLIDSVTKYHPSIQQGEELNLADQELSRGLEEVQTHQNNYLRIQQLRESSNALDTQIRDTLSNLATTRKDIVTTQTTTFPSGPSYPIAYEELLNYARRISKTTMPPAGTIKAAPPTPDVPEVQTPGGQTPAAQTPGPESQAASIMTPSAPASSQVQSPAVINGTPAVSQEPATQQSSMSANTVLPSEWTQFLNPLTDQIFLPWPNDLQLGAGSLAANQLLQEQGIDPKGYDPAEEEERKRREEEERKQKEEEDRIAQEEREKKQREERERQRIERERQREKDQEAWRRASLVGGPAAPGEQRSPTGPPQQKAQFQFTNLDDLDDDDDDD
Length346
PositionMiddle
OrganismGibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium fujikuroi species complex.
Aromaticity0.05
Grand average of hydropathy-1.064
Instability index64.72
Isoelectric point4.66
Molecular weight38770.02
Publications
PubMed=20237561

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364141
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP33849
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.86|      14|      15|     258|     271|       1
---------------------------------------------------------------------------
  258-  271 (24.08/10.43)	REEEERKQKEEEDR
  274-  287 (24.77/10.89)	QEEREKKQREERER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.00|      16|      16|     123|     138|       2
---------------------------------------------------------------------------
   97-  107 (22.24/ 7.55)	PSG.....PSYPIAYE
  123-  138 (31.78/13.35)	PAGTIKAAPPTPDVPE
  142-  155 (28.98/11.65)	PGGQTPAA.QTPG.PE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.31|      27|      28|      30|      56|       3
---------------------------------------------------------------------------
   30-   56 (44.57/25.86)	IQQ.GEELNLADQELSRGLEEVQTHQNN
   60-   87 (38.75/21.66)	IQQlRESSNALDTQIRDTLSNLATTRKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.96|      15|      35|     194|     211|       4
---------------------------------------------------------------------------
  194-  211 (22.04/18.98)	SMSANTVLPSewtQFLNP
  230-  244 (25.92/12.92)	SLAANQLLQE...QGIDP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33849 with Med4 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IQQGEELNLADQELSRGLEEVQTHQNNYLRIQQLRES
2) NALDTQIRDTLSNLATTRKDIVTTQTTTFPSGPS
3) NPLTDQIFLPWPNDLQLGAGSLAANQLLQEQGIDPKGYDPAEEEERKRREEEERKQKEEEDRIAQEEREKKQREERERQRIERERQREKDQEAWRRASLVGGPAAPGEQRSPTGPPQQKAQFQFTNLDDLDDDDDDD
4) TMPPAGTIKAAPPTPDVPEVQTPGGQTPAAQTPGPESQAASIMTPSAPASSQVQSPAVINGTPAVSQEPATQQSSMSANTVLPSEWTQF
30
68
210
120
66
101
346
208










Molecular Recognition Features






MoRF SequenceStartStop




1) KDQEAWRRASLVGGPAA
2) PQQKAQFQFTNLDDLDDDDDDD
3) YPIAYEELLNYARRI
298
325
102
314
346
116