<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33842

Description Uncharacterized protein
SequenceMTSRTTMGAHPRPPQRSVSSASLPVQRPPPQRSLSHQQQFMAAASPVRKDASFIDLTADAGDATPNRYHATPRRGGSRLRLELSHNASSSSLPTSESPQSLTPSRIPNSDPFQAMVGSPADSASSTFMPMPTRRPVPSQPRFAPRITATAPAPAKKDIRPKPYTVEIPSVAPRYFSANRPETVVRNPVDPFSKGLNSGYADFFPWNGAHYEDEWSSEAITKGTWDKVNLNVPETSSAKLAIFPALKQKTGLNALSTIFMGVLTQRRHRGQINAPSTFKPPPRVTLTDTKREVWLKDLANPAISLRRLSRTIPHGIRGRTLLDQCLNKNVPAERAVWLAKCVGANEIRGLKRKGVNGAFVMGGELKWARDWTVFVEQFVDAVVAGFGENDWKNRVTYAIRLATNLYSEQLLDRDHYLDWVVSGIENSLQSRIPMWLLIAQIYWKDLLRSRKYGRRLVFALLSHLHVISNDPDRDLLVQLSSRLSALLVSLIRSNPESFINPGAWSTYKDTLHACLRSDDEQARKALHAINSRNSRLVVSSTASPPAGRSQLVKLLDAALKESSDNHLAAACWATSENKALIMRTVVEWATSFHRPGLAKVYAAARLIRQWSQFRVNPTTPILETLDNIAPNDKARKNLVYHLVTELVRTGHFSVSQYMQWTIARGGYHCAAEIDPVSGPCSSRLLVELPLHSLSERKRAERANLLRRAGNYSVAEEEQDIANAIRVVKHVVGLPLLSNDPLSGRKPMSLKRLLQRMGGSSTALRSSIGAHLRDELTGQFIMKGHPLSLTMFTAVRDIMETAEDYAMLSDILGACAKTADSDVLASVADTVHSNLQIFCALDSADELFNSLIERLRMMNEEQRLVPRPLLAALDSLAQRMAGHEVIASQLRQELVQNDRNNAIDACSPVSDIVATPSHQAENNVAEEVEKTLSSGTRLDPPTMNKLFRMIIPALERGWEKEDDTRRVLATLLARIRVFDAHHFDKLMTDWTSHIRSIPNRSSLSTLFPLLIITGCLTMPIIMSTASPPFANIQSLAPESSRGPATYLQELLQLVIMPLPQATGLIAEEAYRFHTEQKCAKFEQSKGLLNLVRNALLEYSTVRNHVDGTEFPLDNIECQESLLETLRTLVLVDSSAVSNALGIKALPAEAVGLVRKVTTKLLIPGDSGDTQISFDHILQIANELTLPFCQLKLNLDLSLPQPSAIEGQDQSSSRFEIFARAMDRAIEAGNIMWTSLLPCLSDDITQHLKTQAQTGFLDLVPSSKAPDFVDTVSRQSLRMAENLLEVVEAIISGQAPPKMAQLSLSMVEKLTDLWEIVAAGPQERPNCHAAVLQHWLPAMLRFVNLHSLSSEPPSAPLPTASATRPPIPPVHDVRARIVLVLCGLLLDLETLPPATVGSLVQQVFDIAILLVDALPEELRANCAKAILLNPGGMPNQGTSSDPRLYYLFSSPPPSPSDNLMLSHREKAATPQSAAARGMGAQYGIGPVVQERLSPFILRRWEVLSEPTPNVGENDTSLSLGLFEAIKLQ
Length1525
PositionKinase
OrganismGibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium fujikuroi species complex.
Aromaticity0.06
Grand average of hydropathy-0.189
Instability index53.41
Isoelectric point8.68
Molecular weight168197.79
Publications
PubMed=20237561

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats
>MDP33842
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     262.76|      90|      99|     770|     868|       1
---------------------------------------------------------------------------
  770-  868 (131.17/96.94)	LrDELTGQfiMKGHP.....LSLTMFTAVRDimETAEDYAMLSDILGACAKTADSDVLASVADTVHSNLQifcaLD..SADELFNSLIERL.RMMNEEQ..RLVPRPLL
  871-  970 (131.59/73.59)	L.DSLAQR..MAGHEviasqLRQELVQNDRN..NAIDACSPVSDIVATPSHQAENNVAEEVEKTLSSGTR....LDppTMNKLFRMIIPALeRGWEKEDdtRRVLATLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.33|      27|      99|    1321|    1353|       2
---------------------------------------------------------------------------
 1321- 1353 (47.94/41.78)	RPNCHAAVLQH..WLPA..mlrfvnLHSLSSEPPSAP
 1416- 1452 (41.39/23.21)	RANCAKAILLNpgGMPNqgtssdprLYYLFSSPPPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     190.81|      57|      86|      14|      73|       5
---------------------------------------------------------------------------
   16-   73 (95.47/57.24)	RSVSSA..SLPVQRPPPQRSLSHQQQFMAAASPVRKDASFIDLTADAGDATPnRYHATPR
  121-  179 (95.34/47.59)	DSASSTfmPMPTRRPVPSQPRFAPRITATAPAPAKKDIRPKPYTVEIPSVAP.RYFSANR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.58|      28|      34|     387|     415|      13
---------------------------------------------------------------------------
  387-  415 (45.07/32.02)	ENDWKNRVTYAIrLATNLYSEQLLDRDHY
  424-  451 (50.51/31.39)	ENSLQSRIPMWL.LIAQIYWKDLLRSRKY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.16|      43|      47|     664|     708|      14
---------------------------------------------------------------------------
  666-  708 (75.55/43.77)	YHCAAEIDPVSGPCS.SRLLVELPL...HSLSERKRAERANLLRRAG
  710-  756 (64.61/30.98)	YSVAEEEQDIANAIRvVKHVVGLPLlsnDPLSGRKPMSLKRLLQRMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.50|      17|      34|    1093|    1109|      17
---------------------------------------------------------------------------
 1093- 1109 (29.96/19.29)	LLEYSTVRNHVDGTEFP
 1128- 1144 (26.53/16.23)	LVDSSAVSNALGIKALP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33842 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MTSRTTMGAHPRPPQRSVSSASLPVQRPPPQRSLSHQQQFMAAASPVRKDASFIDLTADAGDATPNRYHATPRRGGSRLRLELSHNASSSSLPTSESPQSLTPSRIPNSDPFQAMVGSPADSASSTFMPMPTRRPVPSQPRFAPRITATAPAPAKKDIRPKPY
1
163










Molecular Recognition Features






MoRF SequenceStartStop




1) DIRPKPYTV
2) RLYYLF
157
1440
165
1445