<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33840

Description Uncharacterized protein
SequenceMEHIMKTSGAAKRSQKGHGIRHRGQINAPSTFKPPPRVTLTDTKREVWLKDLANPAISLRRLSRTIPHGIRGRTLLDQCLNKNVPAERAVWLAKCVGANEIRGLKRKGVNGAFVMGGELKWARDWTVFVEQFVDAVVAGFGENDWKNRVTYAIRLATNLYSEQLLDRDHYLDWVVSGIENSLQSRIPMWLLIAQIYWKDLLRSRKYGRRLVFALLSHLHVISNDPDRDLLVQLSSRLSALLVSLIRSNPESFINPGAWSTYKDTLHACLRSDDEQARKALHAINSRNSRLVVSSTASPPAGRSQLVKLLDAALKESSDNHLAAACWATSENKALIMRTVVEWATSFHRPGLAKVYAAARLIRQWSQFRVNPTTPILETLDNIAPNDKARKNLVYHLVTELVRTGHFSVSQYMQWTIARGGYHCAAEIDPVSGPCSSRLLVELPLHSLSERKRAERANLLRRAGNYSVAEEEQDIANAIRVVKHVVGLPLLSNDPLSGRKPMSLKRLLQRMGGSSTALRSSIGAHLRDELTGQFIMKGHPLSLTMFTAVRDIMETAEDYAMLSDILGACAKTADSDVLASVADTVHSNLQIFCALDSADELFNSLIERLRMMNEEQRLVPRPLLAALDSLAQRMAGHEVIASQLRQELVQNDRNNAIDACSPVSDIVATPSHQAENNVAEEVEKTLSSGTRLDPPTMNKLFRMIIPALERGWEKEDDTRRVLATLLARIRVFDAHHFDKLMTDWTSHIRSIPNRSSLSTLFPLLIITGCLTMPIIMSTASPPFANIQSLAPESSRGPATYLQELLQLVIMPLPQATGLIAEEAYRFHTEQKCAKFEQSKGLLNLVRNALLEYSTVRNHVDGTEFPLDNIECQESLLETLRTLVLVDSSAVSNALGIKALPAEAVGLVRKVTTKLLIPGDSGDTQISFDHILQIANELTLPFCQLKLNLDLSLPQPSAIEGQDQSSSRFEIFARAMDRAIEAGNIMWTSLLPCLSDDITQHLKTQAQTGFLDLVPSSKAPDFVDTVSRQSLRMAENLLEVVEAIISGQAPPKMAQLSLSMVEKLTDLWEIVAAGPQERPNCHAAVLQHWLPAMLRFVNLHSLSSEPPSAPLPTASATRPPIPPVHDVRARIVLVLCGLLLDLETLPPATVGSLVQQVFDIAILLVDALPEELRANCAKAILLNPGGMPNQGTSSDPRLYYLFSSPPPSPSDNLMLSHREKAATPQSAAARGMGAQYGIGPVVQERLSPFILRRWEVLSEPTPNVGENDTSLSLGLFEAIKLQ
Length1280
PositionKinase
OrganismGibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium fujikuroi species complex.
Aromaticity0.05
Grand average of hydropathy-0.116
Instability index50.99
Isoelectric point7.63
Molecular weight141545.18
Publications
PubMed=20237561

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33840
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.46|      29|      47|     419|     463|       1
---------------------------------------------------------------------------
  419-  463 (40.91/53.11)	GGYHcaaeidpvsgpcssrlLVELPLHS...LSERKRAERANLLRRAG
  480-  511 (44.55/24.71)	VVKH................VVGLPLLSndpLSGRKPMSLKRLLQRMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     211.31|      47|      47|     227|     273|       2
---------------------------------------------------------------------------
  172-  224 (34.02/15.97)	.DWVVsgienSLQSRIPMwLLIAqiywkdLLRSR.....KYG............RRLVF..........ALLSHLHviSND
  227-  273 (79.74/47.58)	RDLLV.....QLSSRLSA.LLVS......LIRSNPESFINPG............AWSTYK........DTLHACLR..SDD
  277-  318 (56.89/31.78)	RKALH.....AINSRNSR.LVVS......STAS.P.....PA............GRSQLV........KLLDAALK.eSSD
  321-  379 (40.66/20.56)	LAAAC.....WATSENKA.LIMR......TVVEWATSFHRPGlakvyaaarlirQWSQFRvnpttpilETL..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     253.17|      86|     266|     514|     609|       3
---------------------------------------------------------------------------
  514-  608 (120.94/108.45)	STALRSSIGAHLrDELTGQfiMKGHP.....LSLTMFTAVRDimETAEDYAMLSDILGACAKTADSDVLASVADTVHSNLQifcaLD..SADELFNSLIERL
  615-  707 (132.23/84.52)	QRLVPRPLLAAL.DSLAQR..MAGHEviasqLRQELVQNDRN..NAIDACSPVSDIVATPSHQAENNVAEEVEKTLSSGTR....LDppTMNKLFRMIIPAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     180.17|      59|     266|     870|     930|       4
---------------------------------------------------------------------------
  870-  930 (91.72/74.69)	CqeSLLETLRTLVLVD.SSAVSNALGIKALPAEAV.GLVRKVTTK..LLIPGDSGDTQISFDHIL
 1134- 1196 (88.45/65.07)	C..GLLLDLETLPPATvGSLVQQVFDIAILLVDALpEELRANCAKaiLLNPGGMPNQGTSSDPRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.28|      25|      41|      44|      72|       6
---------------------------------------------------------------------------
   18-   64 (28.86/28.89)	HGIRHrgqinapstfkppprvtltdtKREVWLKDLAnPAISLRRLSR
   68-  106 (37.41/20.80)	HGIRG.......rtlldqclnknvpaERAVWLAKCV.GANEIRGLKR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33840 with Med12 domain of Kingdom Fungi
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