<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33839

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMETSEYETNTLSINNIASVAFRIYEPPPDQSHAFQSSALEIQSSLRDQGKLVSYDADRVGIWIFQIVSKDGTSNLVNSAPGSSLEASGYTLGMVEEGTLEPVALQKSRIPGNTTQNAPNNATSTSSPAESNSRNPLISPTQVAGGALPDGGSQSSAQAAEMKTPRIVPKIIYEQFIVAVISSIAFAFCSRSMAIPLNYRTMLIPPLQADANERERGSLQADPVIGTFKTYLTTTGSLVVSLTFSYCKNLATVEDVLTGDSSSPSSSVLAAPYGVFATKQNFANGDGSDRSLAQTPNTQALSVRSIPDTNDSQWKHSCLKALEYCGLNPSQFKSSSWVNLLISKPASQDAEGESKRSRATVPWPGPLCFRKKPLEMSTTHRVGDTMLSGHEECHDPLGDARGWFAGASEREERISKRRAERMYAVPKEVNGANLLAQNLNGQSPLTMRRPSTAAAGVMYPTPPDAIQQHIGITPSLDGAISSPNNPPPTLAIVDADITMPTATPMPDAENDTWGGHHEQKRERSDSNAMGDSDDVMNDLGEDVFGDHDVTEDDFNFFDGPDSNDLDMDMPDLQPVPTAPAPQVMPPPVLSHPHPHPHPHPQPQPHKVIEPQPEVKPKPKTNDSVFAKPELKHARSSLNEELNHRIKVERPDTAKRGSSPFDPATVFKRVRASLSSPTKDNFAVQPPRRKSSVFEKVEFDPKIPLINKKYEHGGAFDFSKDQSNGDSRPSAHNLSRDEYLEGQGKLKQTSKSLLGNSLIRSLTGIDASTTHASPQRLNGHDWISEESDLESDGDDISSISGGPVSPVKSSIKRTVVDDDALSQATTSRETELLDDFTDEQLAIELPKLSKTESPEMLLNRFFLDPEPLNVDVGLSNHDFVEIAQIITDQAATGRLEIGIEHKAESSVSLATMRSHELNIARNSLQLLHDVMPSNLGTPTAVRLKALLEIQDLPLVGQPSRLQPRPIPGRDPNAEQLRANNLYQIPVPHLEVRRSETKLSVLPSSMSFWEGLGLSPSWGTKDISALCIFPGWKGMSDHVGSFLGRLKSVYESLKLGTLNNLPLYGDWDDGVLPYEVDRISTSPDATVTGHGSALVESMEVLRSSLSELKSKDKNLVVYFVYSPDNPASIIEACTAFYRCFDEYSDLLAARRESPQNELVLQLVSLDMISSTTSLVVPTPAEMIKLCIETYDRCTLFLDTEFGGPTPAPAVMLEQPPPRMIDFKLTTSPSQSLMHENSCLHVGYAESLDGRWITAAWTDNRGQRQATTSYSITRSRTPDRSVSQHKAAIIAEIWATTLTMISIWKVHWRVIITKSGVMDQREVEWWQAASTLDDKHSFTMIIMSVDTNPSLQLVPPIVKIPHTATSAFYSTPVSTPQANIVSPEQTTTPATPMRDASTLAATPTAEGAAEAEADSFLIDATDQTWGAIVGHRLCNSTTLLEVRPALASGYLIKRTGTKIEDPPVVMEVNLVHTEATPRAYEPLLREMLCYFRGLGTLARARGVVDREMDVRPWHIAAAEKGVRALHLLL
Length1525
PositionKinase
OrganismGibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium fujikuroi species complex.
Aromaticity0.06
Grand average of hydropathy-0.393
Instability index49.45
Isoelectric point5.28
Molecular weight166709.52
Publications
PubMed=20237561

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33839
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.00|      24|      96|     626|     657|       2
---------------------------------------------------------------------------
  628-  654 (33.10/35.21)	ELKHARSSLneELNHRI...KVERPdTAKR
  914-  940 (36.90/12.78)	ELNIARNSL..QLLHDVmpsNLGTP.TAVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.16|      21|     255|     516|     542|       4
---------------------------------------------------------------------------
  516-  541 (24.23/29.59)	HEQKrerSDSNAMgDSDDvMNDLGED
  547-  567 (38.93/18.89)	DVTE...DDFNFF.DGPD.SNDLDMD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     151.50|      33|      96|     473|     505|       5
---------------------------------------------------------------------------
  473-  505 (61.61/23.34)	PSLDGAISSPN...NPPPTLAIVDADITMPTATPMP
  569-  603 (58.81/21.99)	PDLQPVPTAPApqvMPPPVLSHPHPH.PHPHPQPQP
 1369- 1390 (31.09/ 8.54)	......VSTPQ...A.....NIVSPEQTTTPATPMR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.44|      10|     906|     506|     515|      17
---------------------------------------------------------------------------
  506-  515 (22.82/10.29)	DAENDTWG...GH
 1415- 1427 (17.63/ 6.61)	DATDQTWGaivGH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.29|      30|    1015|      47|      78|      18
---------------------------------------------------------------------------
   47-   78 (44.69/36.30)	DQGkLVSYDADRVGIWIFQIVSKDGtSNLVNS
 1065- 1094 (52.59/33.06)	DDG.VLPYEVDRISTSPDATVTGHG.SALVES
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33839 with Med13 domain of Kingdom Fungi
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