<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33837

Description Uncharacterized protein
SequenceMTSRPGPGIHESLQNRGSGLPPRSQVQRRPAKPISTLVQPDCIDPALEDDRPPTHNAANDAARPPPRGRPPLFYTAMPNYALDMPIHAFPYQPTANLPLPPRPGSIHLRDASQQRRIWPGGSGVKDTPKPGASEVVAPPVHFPGGKAADVFPWTGNSAEDNLSEALVKAGVSNKPQIMNESNTARPSLINNLKNKSGLSTLSTLFVAVLEKRQQTGRLQAPNTFKPPPRLTLRDSTREQWLHDLANPTTGLRRLSRTIPHGLTGKVLLEQCLNKNIPLPRALWLAKCVGINELRAHKRKGQAGTVTWGRGWTSSVEQFIDGVIGGIGQGDWKPRITYALQLATHLYKEHLLDDDHFLDWIVNGLDTCASERLFIWLLVVSISHYWADVTCCRRRGKRLAESLLNQLDRIYRLEEQGPYMAVLQYLENTLVRLLATRPACLLLPTSWTQYSPLLQKLAERRNHAHVTQAIRRLEQRNCRLLKAPQKPSFASQTPAGRVYRILDSVDYNRPVRIEDLSYDCMEIIADAPRLISVLLRWTCTYYREGAHRVYLATRLLRRWNHLGADVYEGIISYLREMTWVATGDPSLLFKVVAELVRSKTFALGRYLQWLIATGSVGHGADLSAPASWPLRLITEIPLTGLPDQIRTLRSTLLRGTVHSAESEQRALTYAKHMMSQTLPSLFGLYNSTTDVNEVELDKLSPTVKFELGIWLRRQVAQYAEVNEHVPTKDAPGEETAAVSLLTALDFHIVRSYLERFGDLAILADVVGIATSSLDSSVLASTADTINYHAKAFRAIGAFDPLFARVTARYAALRTIRFPDRELLLSLASLARTAQTDGQLPQLLNYDLSQLSQRNSLIACSPASDNMGEVMQTGSSSDDEIERILSSGTSMDQQMMGRVLRKIVSNIEEHSGKGSVHLNSHHGWFHRLRCFDEPTFDMVVNEWLASSLMAQRTDSLRVALPTLAGSGCVALTSFLEILRACVARFKTSPSEGCFQSALKGMHIILPSDALAQSCSPQDAYRYRLEQRKLCLETEGRFMQCLGELIGLGSIISSHKAQTQLASLLRSRPVLSILNTYIATDPGCLSKLSKDVSSDCLNQSLDALLDPNDHLGLSQKPPEQQVATVFSLASELSLPICQAAIERIFSSRATASEGPSEALSATLLNAIRTAVEEDRPSGLELLASLDASLTGQIRQNAEREIINASAFLTALSTTKVEESEVVSPKTVQKFLAVIDLTPSKGAENTEQSGMLQALIERLKGMTQALDDNKLSVLDFYAWLTALLRLAVSHASTMISNATHPYQTAMMSVMAAMLTHPTLELYPTITEHVFDVTVFLSDYISDDVRFHVTRLDGARLANDSRCVFILGVTAPVDGWLVLARPVNAPPNQTSSQPPTPTPLQGQPTPYQNPQAQATGSSTPQQRYTSQQQQRQQQMQAAQQAQQTRNMQQYSQHPQNKMLPAQLQRTPSGQATPSPLSQMQQMQQMQQRAMQPSPVYSQRPTPAASQGQGVTQAPGKLQLKQEKEIRHYPFVQPRWEILAESSGNPTGNETAINLSLFGARRV
Length1557
PositionKinase
OrganismBipolaris oryzae ATCC 44560
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Bipolaris.
Aromaticity0.06
Grand average of hydropathy-0.288
Instability index51.91
Isoelectric point8.82
Molecular weight172335.59
Publications
PubMed=23357949

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33837
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     104.57|      18|      20|    1422|    1439|       1
---------------------------------------------------------------------------
 1403- 1418 (21.21/ 8.11)	....QNPQAQATGSSTPQQR
 1422- 1439 (35.03/18.17)	QQ..QQRQQQMQAAQQAQQT
 1443- 1461 (25.82/11.46)	QQysQHPQNKMLPA.QLQRT
 1473- 1486 (22.51/ 9.06)	QM..QQ.MQQMQ..QRAMQ.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     162.44|      48|      76|      48|      98|       2
---------------------------------------------------------------------------
   48-   98 (85.66/47.67)	EDDRPPthnAANDAARPP...PRGRPPLFYTAMPNYALDMPIHAFPYQPTANLP
  125-  175 (76.78/36.63)	KDTPKP...GASEVVAPPvhfPGGKAADVFPWTGNSAEDNLSEALVKAGVSNKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     750.79|     217|     233|     634|     866|       6
---------------------------------------------------------------------------
  483-  666 (191.06/107.89)	................................................................PQKPSFASQTPAgrvYRILDSVDYnRPV.....RI..............EDLSY..DCMEIIA...DAPRLI...SV..LLRWTCTYYRE.GAHRVYLAtRLLRRWNHLGAdvyegiisylremtwVATGDPSLLFKvVAELVRSKT..........F...ALGRYLQWLIATGSVGHGADLSAPASwplRLITEIPLTGLP..DQIRTLRSTllrGTVHSAESEQRAL
  667-  898 (335.05/212.88)	TYAKH..MMSQTLPSLFGLYNSTTDVNEveldklsPTvkFELGI..WLRRQV.AQYAE.VNEHVPTKDAPGEETAA...VSLLTALDF.HIVRSYLERF..............GDLAIlaDVVGIATssLDSSVLA...STADTINYHAKAFRAIGAFDPLFA.RVTARYAALRT...............IRFPDRELLLS.LASLARTAQ..........TD.GQLPQLLNYDLSQLSQRNSLIACSPAS...DNMGEVMQTGSSsdDEIERILSS...GTSMDQQMMGRVL
  904- 1109 (224.68/123.04)	NIEEHsgKGSVHLNSHHGWFHRLRCFDE.......PT..FDMVVneWLASSLmAQRTDsLRVALPT..LAGSG..C...VALTSFLE...ILRACVARFktspsegcfqsalkGMHII...........LPSDALAqscSPQDAYRYRLEQRKLCLETEGRFM.QCLGELIGLGS...............I.ISSHKAQTQ.LASLLRSRPvlsilntyiaTDpGCLSK.LSKDVSSDCLNQSLDALLDPN...DHLG...................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.29|      10|      18|    1288|    1297|       7
---------------------------------------------------------------------------
 1288- 1297 (19.24/11.12)	STMISNATHP
 1304- 1313 (19.04/10.93)	SVMAAMLTHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     163.16|      40|      69|    1169|    1208|       9
---------------------------------------------------------------------------
 1128- 1158 (39.99/22.28)	ELSLPICQAAIERIFSSRA...................taSEG.P..........S.....EALSA
 1159- 1184 (39.43/21.86)	TLLNAIR..............TA...........V.....EEDRP..........SGLELLASLDA
 1185- 1239 (47.90/28.19)	SLTGQIRQNAEREIINASAFLTA...........LsttkvEESEVvspktvqkflAVIDLTPSKGA
 1240- 1278 (35.84/19.18)	ENTEQ............SGMLQAlierlkgmtqaL.....DDNKL..........SVLDFYAWLTA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33837 with Med12 domain of Kingdom Fungi
Unable to open file!