<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33833

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFLKTCTTNAQAIGDFEAIAYQAISVTRTTTTTSPQSSKQPPPSWSPSEDTRAVEAELRHALHLVAHDTARPWLWLFKPTTVDKLGQASPQLPEIDGYRLQREHTGAIKAIDLVRPPMRPGAPHPPSTNAPQRGLQSGNNPKPAQGSTQPQPSADLPPPPDCFTLYELFTSSVVALISFHVVKDSPVVALNYRTFVSKASKCIDDAQTDVEPQPEVHRLTSINVHWASSGTLLLSTFTDRKNTIRCLSSVSTQSEERQLVGTCIRVAPNGVLATIISFEDPLDSINEEISIRHRKRTKSTSLEQNIEKWKSSVKRWLGWKGYDLPDLDQRTSWVRIRTTLTSSPVLWSPASVGPERDILWPRALCFFHVTNEPDPTVTGTNAISTAGNSNILRWFETPESMGFKDPLDVAQEWFLGKPDRDKILEARKKAKKAEEDAARRKEEHPGLHPSSPLNARGGTYGDLQAVSGVYPTPPDGIAPGTGVSYGDTPTVSGTGSNVVLVPGGNNPAINLSAPPDSVKTEDQQMITTSPAVPSATDNFNASSGNDDLFEDMEEDGYTGDRINDTDFDFFDGPDNDDVDMLDAPALPNDNAPPTHATQDPHPKATTESQAQDDMSDPFAALENALATASEPVMSQDHAKGKEPAHMPAPKIEISDNSGDNKSSPVRRNVSFSRAPTPPLSPSKILKALEPSPPRKSASRIRSERSSESHPDAHFTPVVFNRKMSLSDAKYQGGRFSAHRPTTPTGQVQLSPSPARNAPTTQPKSLREFPLLSKLRLAAGIASTNRIPEIASLARAVSDDSDSSSEVSDASGNDSGDEEVEVTPAAIMHSLTMPAKRKLQSEGNATPLSVTSFAESLGGDWLELYGLHLDEANLSSFEPSLWDWSLVNVPSPAERPVAGARYSLPALLPGPAQMPDTPTSQPDPAYEVPDEKPLSAKDSISITQIVTDQLVSTTLDMLNEDPPVKSEFNNDAVAETPWYNIIKNLFPTVTDCDLPTLASVNEVFQDYAALAKAQQRPPARKSDSPAVTGSHMYQIQAPFLRVRRAETHWDLLPPAVAFWETLGLSPISHPKNIVTFCVYPHSEAIRPCLESFLLNLQLTYDGCKLGNHSRVETAAEYEGGLVPVRATSTITPRETFKLLRDTCIQLGKHLALQYGQIREQQDSKVDAFVIYMIDPFGGSSAVWELCSAFWALFQAYTQGHPGRPDQPQKPDVVLQIIPMKYVASFDAPVILDPSTYMGLAREVYDRCPPSAPSGDKTSLSIYKAPAFHLEETLPRNIPFKLISEPAQDLLRENTYMHLGYAISLDGAWVTAAWTDSCGKSQAVVSYYLGTRMFREIAKEIWQTTIEILQSRRVNWRVCIAKAGVLEREELETWVFLISCPTQINVFVTLLTAVDTDPPYQFTPTVPNPTPATGAGATTPGSTPQAGVSPSDPGPGLTPAATPAADPTATDPAADPEARLIDVTDDTWGIILAHRLHNSHTTTQFSPALISGLLIKRGETLQTSNSIAHPIPDPEQGPIVIAVNFLWIGAVGSSRNAATNLPFPSGTSSSANASASSSISSSDLPSPGGSNLPNPYASNPGTPQSPGPGQEGQRSTTSLMWTPTPQTRTTAEGLLKEVLGQFRALGLLAKLRGMRGTRNGTIPWHVAAAKRGVEGLSKISSGVGTAV
Length1666
PositionKinase
OrganismBipolaris oryzae ATCC 44560
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Bipolaris.
Aromaticity0.07
Grand average of hydropathy-0.404
Instability index51.17
Isoelectric point5.35
Molecular weight180357.00
Publications
PubMed=23357949

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33833
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     333.43|     101|     150|     342|     450|       1
---------------------------------------------------------------------------
  262-  379 (130.31/65.24)	GT.CI.RVAPN.GVL.....ATIISFED.......P.LDsINEEISIRHRKRTKSTSLEQNIEKWKSSVKRwlgwKGYDLPDLdqrtswvrirttlTSSpvLWSPASVGP.ERDILWPRAlcffHVTNEPDPTV..T
  380-  495 (156.41/69.00)	GTNAI.STAGNSNILRWFETPESMGFKD.......P.LD.VAQEWFLGKPDRDKILEARKKAKKAEEDAAR....RKEEHPGL.hpssplnarggtYGD..LQAVSGVYPtPPDGIAPGT....GVSYGDTPTVsgT
  496-  556 (46.72/13.41)	GSNVVlVPGGNNPAINLSAPPDSVKTEDqqmittsPaVP.SATDNFNASSGNDDLFE......DMEED.....................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.15|      19|     150|    1410|    1435|       2
---------------------------------------------------------------------------
 1416- 1447 (23.39/14.92)	ATTPGsTPQagvspsDPGPG.........ltpaatPAADPT
 1576- 1609 (28.77/ 7.04)	ASNPG.TPQ......SPGPGqegqrsttslmwtptPQTRTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.23|      43|     150|    1136|    1190|       3
---------------------------------------------------------------------------
 1010- 1059 (66.09/35.98)	LAK..AQQRPPARKSDSPAVTGSHMYQIQaPFlrvRRAETHWDLlppAVAFW
 1146- 1190 (75.14/49.58)	LGKhlALQYGQIREQQDSKVDAFVIYMID.PF...GGSSAVWEL...CSAFW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.48|      15|      15|    1521|    1535|       4
---------------------------------------------------------------------------
 1521- 1535 (26.93/18.63)	AVNFLWIGAVGSSRN
 1537- 1551 (26.55/18.23)	ATNLPFPSGTSSSAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.55|      13|      15|     730|     743|       6
---------------------------------------------------------------------------
  730-  743 (20.95/18.12)	KYQGGRfSAHR..PTT
  747-  761 (19.60/10.00)	QVQLSP.SPARnaPTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.78|      10|     150|     653|     663|       7
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  653-  663 (14.62/10.36)	EISDNSGdNKS
  806-  815 (19.16/ 8.58)	EVSDASG.NDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.21|      15|     106|      37|      51|       9
---------------------------------------------------------------------------
   37-   51 (31.76/13.58)	QSSKQPPPS..WSPSED
  146-  162 (27.45/10.57)	QGSTQPQPSadLPPPPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.17|      13|      16|     884|     896|      10
---------------------------------------------------------------------------
  884-  896 (26.10/16.09)	WSL.VNVPSPAERP
  902-  915 (21.07/11.09)	YSLpALLPGPAQMP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.54|      31|     132|    1483|    1516|      12
---------------------------------------------------------------------------
 1483- 1516 (46.25/36.46)	QFSpALisGLLIK.RGETLQTSNSIAHPIPDPEQG
 1620- 1651 (52.29/29.94)	QFR.AL..GLLAKlRGMRGTRNGTIPWHVAAAKRG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33833 with Med13 domain of Kingdom Fungi
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