<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33822

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDSMVKEWTVLLDRCLERRVQSDVFAAAVAQLHAKSPLPGRKLAALLLRPRVADNSNIDPRTVIYLEQLLSLKKLDASDVLIVALLYSKVRLPVKTEEKPSKDAKWSNPPELEELIFHRLHKVFASEERPVNNVEAVHTLAVVARWMQAMVTSHTSDTMIQAMAGIQQPQQQSINVREGLAMLVVGVIENSKILRILNHPKAEEVRKELMKSLSSFIPFLSNNSAGSQTSLSLANRLEISQKQHDLYEKLPNVNGEGNESAGLEVAALQLDAVMELPQANTRAGLYVFLNSLLVARPLTDDFVIISHLHTRYKLEPQNMATDLITAAFDILANAMYRNEPTQTLFYLKSFLINKIPTLLTQISGSIFPMTVEMCITQALSHVDPNAFPSFSQGFDDIMGSNNSLSDVRQDYLNACVLHGLLPAGTVERLLGEAPMQGPPAKRYERKELLNQCKSNFDKVSVYIDELENLDGNAGAIVAAVADFISHLCDTQTTMYLKQLCCLIFKKPQAMDVMLQFTSPASILQPLCQFLEDWHYDSDQGEYQPLYDEFGAILVLVMAFVYRYDLVYHDIGIAHDTFIAKLLQHGHHSIPPDELTEEQGRHLGSWLKGLYDSDKEGLSNEVFASCRPQEFYLIVPTLFHQTVVACSLGVLSFETVKGGLEYLGETFLMPSLIGGLTWMASYALLQTHNDLDAMTRIFNAILLSAPSSGDAQAMHSTIIAMVSSRLEKCFRTLQRREPNRNNFDSFLQAIKVHAHYERTVFATMKELDQWTNAPNSTLNTSLRHTVQQLSQWASTASMQPNPPSYTHRQLYASLKMLGAARTLRAIVDEVKTQTDSGNGAAALDVGVSIICAPTVEDSPISVDWVGSTVPAPTPQRTRMNLREMLKQDFDNAASLVATDPLAAETIVRLHRRVEAHFTSLAESGLQAPPINIPSVNMADMQSQSISEHLNRAMDDAAAASMVEDISNMDNKALQRSMDELASTEGLDLSGIGMGNGDAGTGDMSTDLGNLPDLDLGDMGGMGIDMDMNMDMGGGGGGDDDWGLDFDNM
Length1047
PositionTail
OrganismBipolaris oryzae ATCC 44560
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Bipolaris.
Aromaticity0.07
Grand average of hydropathy-0.127
Instability index40.49
Isoelectric point5.04
Molecular weight115652.62
Publications
PubMed=23357949

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33822
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.61|      19|      25|     985|    1007|       1
---------------------------------------------------------------------------
  985- 1007 (27.24/28.82)	LDLSGIGmGNG.DAgtgDMSTDLG
 1012- 1031 (36.37/21.67)	LDLGDMG.GMGiDM...DMNMDMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.54|      18|      27|     935|     956|       3
---------------------------------------------------------------------------
  935-  956 (25.85/26.42)	NMADMQSQSisehLNRAMDDAA
  963-  980 (30.69/19.29)	DISNMDNKA....LQRSMDELA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.60|      17|      27|     298|     316|       4
---------------------------------------------------------------------------
  298-  316 (25.58/23.35)	LTDDFVIIShlHTRYKLEP
  324-  340 (30.02/19.49)	ITAAFDILA..NAMYRNEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.67|      36|      53|       2|      39|       5
---------------------------------------------------------------------------
    2-   39 (59.41/45.47)	DSMVKEWTVL.LDRCLE.RRVQ.SDVFaaAVAQLHAKSPLP
   55-   93 (46.26/29.15)	NSNIDPRTVIyLEQLLSlKKLDaSDVL..IVALLYSKVRLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     194.90|      61|      74|     638|     701|       6
---------------------------------------------------------------------------
  638-  701 (96.23/69.34)	FHQTVVACSLGVL..SFETVKgGLEYLGETFlmPSLIGGLTWMASY..ALLQTHNDLDAMTRIFNAIL
  713-  777 (98.67/60.59)	MHSTIIAMVSSRLekCFRTLQ.RREPNRNNF..DSFLQAIKVHAHYerTVFATMKELDQWTNAPNSTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.15|      22|      49|     526|     564|       7
---------------------------------------------------------------------------
  526-  550 (38.61/57.81)	LCQFLEDWHYDSDQGEyqpLYDEFG
  578-  599 (36.55/15.49)	IAKLLQHGHHSIPPDE...LTEEQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.17|      16|     148|     341|     356|       9
---------------------------------------------------------------------------
  341-  356 (30.37/19.35)	TQTLFYLKSF..LINKIP
  490-  507 (25.81/15.44)	TQTTMYLKQLccLIFKKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.06|       9|      17|     844|     853|      10
---------------------------------------------------------------------------
  844-  853 (14.09/11.31)	VGvSIICAPT
  864-  872 (17.97/ 9.49)	VG.STVPAPT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33822 with Med5 domain of Kingdom Fungi
Unable to open file!