<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33819

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGILIMNHTASDAATASRHGDSSTAAPNGASAASTALDKYSQLPPEIAHIGPEQYNALSTLLLRVSQESYNDLTSILQKMAALPVAPMANGALPNGLGAANMQGSAESNKRKKLMLLQFAQEQRSKFIKLLVLTEWGKKAASDISKLIDIFSWAGAHARNMDAADDQLERIKMLSNIARENNPDIATALQVLSTGKAAWMPSLDYIPPKPISSDEALKLLRYMNTSLSIRLNVHENLPRHLRNWRIHSGRVTFIVKGQLEFDVMSFVEDASEQWFLIDLRLLFTPAPTVTVGSRFFMQLKQQADFVLKDKGLSGLFDFLNNFVLTHKISVLRSQAAALVRAGWAGSIKVEPVHRLLVVQYWTNKPGKKNWIEIGVSNNRLNNAKSSWKGPPIPSLTTRWFRQGKEVKDANFAFDWTNLSMEKVIKLVIARHTSDILRSTKESMKTGVIAETDLSEAEPADCRLNATLGTRSASITLSLEPVTGNHIIRPASALSARAENAFNLGREPAQMAHVMTQVLAGTLLGLIQRNAQQLGWQTVARQSLTPQMVKAAVKLDVISSVLYWPRGWSPNWAFAATIDSSGESWWVLEIGSTGNRIEHAEQIRMNRPDMSPLPINRSTLASLERVAVQLLSFRVIARQLEKEKKMYALEEVLGQTPASAQGRRIARRWVLRVQTPDLLTSSTKDDKWLEGDIKITCEGLRVGGQNVWHVASGKMVKSVAADMHKLMAASPQKAFKFSDDGNFRILLSTPFGHDILGELRARLRDVDRLRSFATTLQKRRMRLASSSLQRVQFFYGPSPYTATVNFSSEKEVTIELSSKNPHHRILNLLTHIANDRLPSFMSLDSNDATGLDRFCTTLVLTRPLFKAIRDIEQRSPGNCRNPAIHVHSILKYRITYENPVCTFDVCLQPKDDQVFWFVEDNLRPKDPNVLPTPERAQGHRRLDNLQEKLKELFGSKGLGWFGTRNGMIAELDAIPDALRKLDECVLSCKMEGGYVAPPPLERPAQQAQNPGQGMSKTNGVQQGNQQQQQQQQHHQQQQHQHQQQQQARMQQQQQHQARQQQQGQQQMRMQQSNQRIQQPNGRQPQHMQNARQHMQHQQGRGGRPGQTQNNVIEID
Length1115
PositionTail
OrganismBipolaris oryzae ATCC 44560
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Bipolaris.
Aromaticity0.06
Grand average of hydropathy-0.458
Instability index49.43
Isoelectric point9.74
Molecular weight125094.39
Publications
PubMed=23357949

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33819
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     128.54|      15|      15|    1035|    1049|       1
---------------------------------------------------------------------------
 1019- 1033 (25.08/ 9.32)	GVQQGNQQQQQQQ..QH
 1035- 1049 (31.42/13.40)	QQQQHQHQQQQQA..RM
 1051- 1067 (25.50/ 9.59)	QQQQHQARQQQQGqqQM
 1069- 1083 (25.31/ 9.47)	MQQSNQRIQQPNG..RQ
 1087- 1100 (21.24/ 6.84)	MQNARQHMQHQQG..R.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.58|      42|      66|     730|     772|       2
---------------------------------------------------------------------------
  730-  772 (70.21/58.20)	SPQKA.FKFSDDGNFRILLSTPFGHDILGELRARLRDvDRLRSF
  798-  840 (69.36/52.29)	SPYTAtVNFSSEKEVTIELSSKNPHHRILNLLTHIAN.DRLPSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      73.86|      16|      16|     130|     145|       4
---------------------------------------------------------------------------
  113-  128 (23.54/12.88)	KKLMLLQFAQEQRSKF
  130-  145 (24.29/13.53)	KLLVLTEWGKKAASDI
  147-  162 (26.03/15.03)	KLIDIFSWAGAHARNM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.87|      31|      53|     362|     393|       5
---------------------------------------------------------------------------
  362-  393 (54.47/44.40)	WTNKPGKKnWIEIGV...SNNRLNNAKSSWKGPPI
  416-  449 (46.40/32.05)	WTNLSMEK.VIKLVIarhTSDILRSTKESMKTGVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.39|      11|      16|     305|     316|       6
---------------------------------------------------------------------------
  305-  316 (14.87/13.91)	DFVLKDKgLSGL
  322-  332 (19.52/12.01)	NFVLTHK.ISVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.84|      20|      65|     591|     610|       8
---------------------------------------------------------------------------
  591-  610 (37.77/21.17)	GST.....GNRIEHAEQIRMNRPDM
  654-  678 (31.08/16.24)	GQTpasaqGRRIARRWVLRVQTPDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.99|      15|      16|      14|      28|      10
---------------------------------------------------------------------------
   14-   28 (25.40/19.12)	AATASRHGDSSTAAP
   31-   45 (24.60/18.25)	ASAASTALDKYSQLP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33819 with Med14 domain of Kingdom Fungi
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