<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33818

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFLKTCTTNAQAIGDFEAIAYQAISVTRITTNTTTTSTTTSPQSSKQPPPSWSPSEDTRAIEAELRHALHLVAHDAARPWLWVFKPTTVDKLGQASPQLPEVDGYRLQREHTGAIKAIDLVRPPMRPGAPHPPATSNHPPSTNAPQRGLQSGNNPRPAQQGSTQPQQSADPPPPPDCFTIYELFTSSVVALISFHVVKDCQVVALNYRTFVSKASKSIADAQTEVDPQPEVHRLTSINVHWASSGTLLLSTFTDRKNTIRCLSSVSTQIEERQLVGTCIRVAPNGVLATIINFEDPLDSINEEISIRHRKRTKLTSLEQNIEKWKSSVKRWLGWKGYGLPDLDQRASWVRIRTTLISSPILSSPASVGPERDILWPRALCFFHVVNEPDLTITGTNAISAAGSSSILSWFETPESMGFKDPLDVAQEWFLGKPDRDKILEARKKAKKAEDDAARRKEEHPGLHPSSPLNARGGTYGDLQAVSGVYPTPPDGIAPGTGVSYSDTPTVSGAASNVVLVPGGSNPAINLSAPPDSAKTEDQQMITTSPAIPPAADNFNTSSGNDDLFEDMEEDGYTGDRINDTDFDFFDGPDNDDVDMLDAPALPNDNAPPTHATQDTHPKATTEPQAQDDMSDPFAALENALATASEPTMSQDHAKGKEPAHMPAPKIEISDNSGDNKSSPVRRNVSFSRAPTPPLSPSKILKALEPSPPRKSASRTRSERGSESHPDAHFTPVVFNRKMSLSDAKYQGGRFSAHRPTTPTGQVQLSPSPAKNTATTQPKSLREFPLLSKLRLAAGIASANRIPEIASLARAVSDDSDSSSEASDASGNDSEDEEVEVTPVAIMNSLTMPAKRKLQSEGNATPLSVTSFAESLGGDWLDLYGLHLDEANLSSFEPSLWDWSLVNVPSPAERPVAGARYSLPALLPGPAQMPDTPTSQPDPAYEVPDEKPLSAKDSISITQIVTDQLVSTTLDMLNEDPPTRSEFNNNAAAETPWYKIIKNLFPTVTDCDLPTLAGINEVFQDYAALAKAQQRPPARKSDSPAVTGSHMYQIQAPFLRVRRAETHWDLLPPAVAFWETLGLSPISHPKNIVTFCVYPHSDAIRPCLENFLLNLQLAYDGCKLGNHSRVETAVEYEGGLVPVRATSTITPRETFKLLRDTCIQLGKLLALQYGQIREQQDSKVDAFVVYMIDPFGGSSAVWELCSAFWALFQAYTQGHPGRPDQPQKPDVVLQIIPMKYVASFDAPVILDPSTYMGLAREVYDRCPPSAPSGDKTSLSIYKAPAFHLEETLPRNIPFKLISEPAQDLLRENTYMHLGYAISLDGAWVTAAWTDSCGKSQAVVSYYLGTRMFREIVKEIWQTTIEILQSRRVNWRVCIAKAGVLEREELETWVFLISCPTQINVFVTLLTAVDTDPPYQFTPTVPNPTPATGAGATTPGSTPQAGVSPSDPGPGLTPAATPAADPTATDPAADPEARLIDITDDTWGIILAHRLHNSHTTTQFSPALISGLLVKRGETLQTSNSIAHPIPDPEQGPIVIAVNFLWIGAVGSSRNATTNLPFPSGTSSSANASASSSISSSDLPSPGGSNLPNPYASNPGTPQSPGPGQEGQRSTTSLMWTPTPQTRTTAEGLLKEVLGQFRALGLLAKLRGMRGTRNGTIPWHVAAAKRGVEGLSKISCGAGTAV
Length1681
PositionKinase
OrganismBipolaris zeicola 26-R-13
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Bipolaris.
Aromaticity0.07
Grand average of hydropathy-0.388
Instability index48.28
Isoelectric point5.37
Molecular weight181629.52
Publications
PubMed=23357949

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33818
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     356.17|      96|     128|    1378|    1473|       1
---------------------------------------------------------------------------
  606-  666 (62.69/18.89)	................................................NAP.PTHATQDTHPKATTEPQAQDDMSD.PF..AALENALATASEPTmsqdhakGKEPAHM.PAPK
  905-  947 (34.33/ 6.92)	.............................................................PSPAERPVAGARYSL.PAllPG..PAQMPDTPTS.......QPDPAYEvPDEK
 1378- 1473 (176.18/66.80)	GVLER..EELET...WVFLISCPTQ..INVFVTLLTAVDTDPPYQFTPTVPNPTPATGAGATTPGSTPQAGVSPSD.PG..PGLTPAATPAADPT.......ATDPAAD.PEAR
 1506- 1582 (82.96/27.45)	GLLVKrgETLQTsnsIAHPIPDPEQgpIVIAVNFLWIGAVGSSRNATTNLPFPS.GTSSSANASAS...SSISSSDlPS..PG...............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     276.27|     108|     122|     294|     415|       2
---------------------------------------------------------------------------
  294-  356 (60.81/49.21)	...............................................................FEDPLDsINEEISIRHRKRTKLTSLEQNIEKWKSSVKRWlGWKGYGL.PD..LDQRASwvrIRTTL
  357-  479 (163.13/127.73)	ISSPILSSPASVGPERDILWPralcffhvvNEPDLTITGTNAI.SAAGSSSILSWFETPEsmgFKDPLD.VAQEWFLGKPDRDKILEARKKAKKAEDDAARR.KEEHPGLhPSspLNARGG...TYGDL
  482-  532 (52.34/26.67)	VSGVYPTPPDGIAPGTGVSYS.........DTPTVSGAASNVVlVPGGSNPAINLSAPPD.....................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.82|      13|      15|     553|     567|       3
---------------------------------------------------------------------------
  553-  565 (22.90/ 6.95)	DNFNTSSGNDDLF
  571-  583 (22.92/ 9.60)	DGYTGDRINDTDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.58|      11|     128|      41|      51|       4
---------------------------------------------------------------------------
   41-   51 (23.55/10.95)	TSPQSSKQPPP
  164-  174 (24.04/11.36)	TQPQQSADPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.93|      19|     128|    1064|    1085|       5
---------------------------------------------------------------------------
 1064- 1085 (32.19/24.60)	WDLlppAVAFWETLGLSPISHP
 1198- 1216 (39.74/21.37)	WEL...CSAFWALFQAYTQGHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     184.98|      59|     141|    1098|    1161|       6
---------------------------------------------------------------------------
 1098- 1161 (92.96/55.88)	DAirPCLENFLLNLQLA...YDGCKLGNHSRVETAVE.YEgglVPVRATSTITPRE.TFKLLRDTCIQL
 1241- 1304 (92.01/44.46)	DA..PVILDPSTYMGLArevYDRCPPSAPSGDKTSLSiYK...APAFHLEETLPRNiPFKLISEPAQDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.34|       9|      21|     867|     876|       7
---------------------------------------------------------------------------
  867-  876 (14.66/11.41)	SFAESLgGDW
  891-  899 (21.68/11.78)	SFEPSL.WDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.74|      12|      15|     724|     735|       8
---------------------------------------------------------------------------
  724-  735 (24.51/17.37)	SHPDAHFTPVVF
  740-  751 (21.22/13.74)	SLSDAKYQGGRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.90|      23|     135|    1028|    1054|      10
---------------------------------------------------------------------------
  123-  146 (43.85/15.37)	RPPMRPgAPHPPATSNHPPSTNAP
 1031- 1053 (44.05/17.17)	RPPARK.SDSPAVTGSHMYQIQAP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33818 with Med13 domain of Kingdom Fungi
Unable to open file!