<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33815

Description Uncharacterized protein
SequenceMTSRPGPGIHESLQNRGSGLPPRSQVQRRPTKPISTLVQPDCIDPALEDDRPPTHNVANDAARPPPRGRPPLFYTAMPNYALDMPIHAFPYQPTANLPLPPRPGSIHLRDASQQRRIWPGGSGVKETPKPGASEAVAPPVHFPGGKVADVFPWTGNGAEDNLSEALVKAGVSNKPQIMNESNTARPSLINNLKNKSGLSTLSTLFVAVLEKRQQTGRLQAPNTFKPPPRLTLRDSTREQWLHDLANPTTGLRRLSRTIPHGLTGKVLLEQCLNKNIPLPRALWLAKCVGINELRAHKRKGQAGTVTWGRGWTSSVEQFIDGVIGGIGQGDWKPRITYALQLATHLYKEHLLDDDHFLDWIVNGLDTCASERLFIWLLVVSISHYWADVTCCRRRGKRLAESLLNQLDRIYRLEEQGPYLAVLQYLENTVVRLLATRPACLLLPTSWTQYGPLLQKLAERRNHAHVTQAIRRLEQRNCRLLKAPQRPSFASQTPAGRVYRILDSVDYNRPVRIEDLSYDCMEIIADAPRLIGVLLRWTCTYYREGAHRVYLATRLLRRWNHLGADVYDGIISYLREMTWVATGDPSLLFKVVAELVRSKTFALGRYLQWLIATGSVGHGADLSVPASWPLRLVTEIPLTGLPDQIRTLRSTLLRGTVHSAESEQRALTYAKHMMSQTLPSLFGLYNSTTDVNEVELDKLSPTVKFELGIWLRRQVAQYAEVNEHVPTKDAPGEETAAVSLLTALDFHIVRSYLERFGDLAILADVVGIATSSLDSSVLASTADTINYHAKAFRAIGAFDPLFARITARYAALRTIRFPDRELLLSLASLARTAQTDGQLPQLLNYDLSQLSQRNSLIACSPASDNMGEVMQTGSSSDDEIERILSSGTSMDQQMMGRVLRKIVSNIEEHSGKGSVHLNSHHGWFHRLRCFDEPTFDMVVNEWLASSLMAQRTDSLRVALPTLAGSGCVALTSFLETLRACVARFKTSPSEGCFQSALKGMHIILPSDALAQSCSPQDAYRYRLEQRKLCLETEGRFMQCLGELIGLGSIIPSHKTQTQLASLMRSRPVLSILNTHIATDPGCLSKLSKDISSDCLNQSLDTLLDPNDHLGLSQKPPEQQVAAVFSLASELSLPICQAAIERIFSSRATASEGSSEALSATLLNAIKLAVEEDRPSGLELLASLDASLTGQIRQNAEREIINASAFLTALSTTKVEESEIVSPKTVQKFLAVIDLTPSKGAESTEQSGMLQALIERLKGMTQALDDNKLSVLDFYAWLTALLRLAVSHASTMISNATHPYQTAMMSTMAAMLTHPTLELYPTITEHVFDVTVFLSDYISDDVRFHVTRLDGARLANDSRCVFILGVTAPVDGWLVLARPVNAPPNQSSSQPATPTPLQGQPTPYQNPQTQATGSSTPQQRYSSQQQQRQQQMQAAQQAQQTRNMQQYSQHPQNKMLPAQLQRTPSGQATPSPLSQMQQMQQMQQRAMQPSPVYSQRPTPAAGQGQGVTQAPGKLQLKQEKEIRHYPFVQPRWEILAESSGNPTGNETAINLSLFGARRV
Length1557
PositionKinase
OrganismBipolaris zeicola 26-R-13
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Bipolaris.
Aromaticity0.06
Grand average of hydropathy-0.289
Instability index51.60
Isoelectric point8.82
Molecular weight172270.52
Publications
PubMed=23357949

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33815
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     141.68|      32|      32|    1385|    1416|       1
---------------------------------------------------------------------------
 1385- 1416 (57.99/31.08)	SSSQPATPTPLQG....QPT....PY.QNPQTQATGSSTPQ
 1420- 1460 (40.04/18.96)	SSQQQQRQQQMQAaqqaQQTrnmqQYsQHPQNKMLPAQLQR
 1461- 1488 (43.65/21.40)	TPSGQATPSPLSQ....MQQ....MQ.QMQQRAMQPS....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     161.51|      47|      76|      48|      98|       2
---------------------------------------------------------------------------
   48-   98 (84.97/57.37)	EDDRPPthnvANDAARPP...PRGRPPLFYTAMPNYALDMPIHAFPYQPTANLP
  126-  175 (76.53/43.14)	ETPKPG....ASEAVAPPvhfPGGKVADVFPWTGNGAEDNLSEALVKAGVSNKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     250.74|      69|     152|     555|     626|       3
---------------------------------------------------------------------------
  309-  365 (86.25/45.44)	RGWTSSVEQFIDGVIGGIGQGDW....KPRITYalQLATHLYKEHLLDDDHFLDWIV.........NGLD......
  556-  626 (115.63/73.06)	RRWNHLGADVYDGIISYLREMTWvaTGDPSLLF..KVVAELVRSKTFALGRYLQWLIATGSVG...HGADLSVPAS
  734-  779 (48.87/23.55)	.........................TAAVSLLT..ALDFHIVRSYL...ERFGDLAILADVVGiatSSLDSSVLAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.11|      20|     174|       2|      24|       4
---------------------------------------------------------------------------
    2-   24 (28.77/24.99)	TSRpgPGIHESLQNRgSGLPPRS
  183-  202 (34.33/17.35)	TAR..PSLINNLKNK.SGLSTLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.76|      10|      15|    1288|    1297|       6
---------------------------------------------------------------------------
 1288- 1297 (19.86/12.13)	STMISNATHP
 1304- 1313 (19.90/12.17)	STMAAMLTHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     367.51|      93|     258|     825|     918|       7
---------------------------------------------------------------------------
  825-  918 (147.64/108.93)	L.ASLAR..TAQTDGQLPQLLNYDLSQLSQRNSLI.ACS..PASDNMGEVMQTGSS.....SDDEIERILSS......GTSMdQQMMGRV..LRKIVSNIEEHSGKGSVH........LNS
  976- 1073 (106.98/72.88)	LrACVARfkTSPSEGCFQSALK.GMHIILPSDALAqSCS..PQDAYRYRLEQRKLC.....LETE.............GRFM..QCLGELigLGSIIPSHKTQTQLASLMrsrpvlsiLNT
 1082- 1181 (112.89/77.40)	L.SKLSK..DISSDC.....LNQSLDTLLDPNDHL.GLSqkPPEQQVAAVFSLASElslpiCQAAIERIFSSrataseGSS..EALSATL..LNAIKLAVEEDRPSGLEL........LAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.21|      13|     130|     100|     115|       8
---------------------------------------------------------------------------
  100-  115 (19.97/16.76)	PPRpgsIHLRDASQQR
  227-  239 (24.23/11.07)	PPR...LTLRDSTREQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.87|      14|      17|     256|     271|      12
---------------------------------------------------------------------------
  256-  271 (19.98/16.26)	RTIPhgLTGKVLLEQC
  274-  287 (26.89/14.15)	KNIP..LPRALWLAKC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.68|      19|     180|     446|     472|      18
---------------------------------------------------------------------------
  448-  469 (25.00/32.01)	QYGpLLQKLAERRNhaHVTQAI
 1244- 1262 (33.68/10.72)	QSG.MLQALIERLK..GMTQAL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33815 with Med12 domain of Kingdom Fungi
Unable to open file!