Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MSDHSAKRQRLDSIGRFSPASPPFDVAAKASGQTTKTLPHPRTPTSPPYSSMNSQSNGGFSTTNTTTSSDRSPQSSVPMAHSLSQSAASASSLHPFPTPASTAGFLSSANVDSDGDATMEESADDDTLRSRCHRLSNHNRQAQSPYTPDGRLKAAQGISGSQLFKLNTDRIEKSRPHASQNLIRLYRLEPLASSVARNDPVTGEKINKLRKSYEGHIKQMQIAGKPKATKMDGVFRDLLMLPEEIWLPNHVQNREADKTALTPDGTGLTPDFSQLLDSAFAGMGPGPLPNADAAKYKAYLGTDDTVKPKAQDAPPQRTTPYTSSAPTPNNHINRGLVRPERSGSKRAYTDAAFQGYGEGFGDDYADSTGGEDTPGGSLANKRRKLQFERTSHSVEVGGARR |
Length | 401 |
Position | Head |
Organism | Bipolaris zeicola 26-R-13 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Bipolaris. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.847 |
Instability index | 53.10 |
Isoelectric point | 9.31 |
Molecular weight | 43139.07 |
Publications | PubMed=23357949 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP33809 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 166.48| 50| 112| 101| 150| 2 --------------------------------------------------------------------------- 101- 150 (88.99/57.18) STAGFLSSANVDSDGDAT.MEESADDDTLRSRCHRLSNH..NRQA.QSPYTPDG 212- 265 (77.50/48.85) SYEGHIKQMQIAGKPKATkMDGVFRDLLMLPEEIWLPNHvqNREAdKTALTPDG --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 38.68| 14| 21| 162| 182| 3 --------------------------------------------------------------------------- 151- 167 (17.98/20.98) RLKAAQGIsgsQLFKLN 175- 189 (20.70/ 6.11) RPHASQNL..iRLYRLE --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 69.28| 20| 27| 42| 61| 4 --------------------------------------------------------------------------- 42- 61 (38.82/17.47) RTP.TSPPYSSMNSQSNGGFS 71- 91 (30.46/12.42) RSPqSSVPMAHSLSQSAASAS --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) AAKYKAYLGTDDT 2) LANKRRKLQFERTSHSVEVG 3) LIRLYRL 4) MSDHSAKRQRLDSIGRFS | 293 378 182 1 | 305 397 188 18 |
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