<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33804

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDFMIKEWTVLLDRCLERRVQSDVFAAAVAQLHAKSPLPGRKLASLFLRPRVADNTNIDPRTVIYLEQLLSLKKLDASDVLIVALLYSKVRLPIKTEEKPSKDVKWSNPPELEELVFHRLHKVFAAEERPVNNVEAVHTLAVVARWMQAMVTSHTSDTMIQAMAGIQQPQQQSINVREGLAMLVVGVIENSKILRILNHPKAEEVRKELTKSLSSFIPFLSNNSAGSQTSLSLANRLEISQKQHDLYEKLPNVNGEGNESAGLEVAALQLDAVMELPQANTRAGLYVFLNSLLVARPLTDDFVIISHLHTRYKLEPQNMATDLITAAFDILANAMYRNEPTQTLFYLKSFLINKIPTILTQISGSIFPMTVEMCITQALSHVDPNAFPSFSQGFDDIMGSNNSLSDVRQDYLNACVLHGLLPAGTVERLLGEAPMQGPPAKRYERKELLNQCKSNFDKVSVYIDELENLDGNAGAIVAAVADFISHLCDTQTTMYLKQLCCLIFKKPQAMDVMLQFTSPASILRPLCQFLEDWHYDSDQGEYQPVYDEFGAILVLIMAFVYRYDLVYHDIGISHDTFIAKLLQRGHHSIPPDELTEEQGRHLGSWLKGLYDSDKEGLSNEVFASCRPQDFYLIVPTLFHQTVVACSLGVLSFETVKGGLEYLGETFLMPSLIGGLTWMASYALLQTHNDLDAMTRIFNAILLSAPSSGDAQAMHLTIIAMVSSRLEKCFRTLQRREPNRNNLDSFLQAIKMHAHYERTVFATMKELDQWTNAPNSTLNTSLRHTVQQLSQWASTASMQPNPPSYTHRQLYASLKMLGAARTLRAIVDEVKTQTDGGNGAAALDVGVSIICSPTVEDSPISVDWVGSTVPAPTPQRTRMNLREMLKQDFDDAASLVATDPLTAETIVRLHRRVEAHFTSLAESGLQAPPISIPSVNIADMQSQSISEHLNRAMDDAAAASMVEDISNMDNKALQRSMDELANTEGLDLSGIGMGNGDAGTGDMSTDLGNLPDLDLGDMGGMGIDMDMNMDMGGGGGGDDDWGLDFDNM
Length1047
PositionTail
OrganismBipolaris zeicola 26-R-13
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Bipolaris.
Aromaticity0.07
Grand average of hydropathy-0.127
Instability index40.64
Isoelectric point5.05
Molecular weight115844.90
Publications
PubMed=23357949

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33804
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      95.67|      21|      21|    1005|    1025|       1
---------------------------------------------------------------------------
  979- 1001 (19.69/ 7.11)	.LANTEGLDLSGIGmGNG.DAgtgD
 1005- 1025 (41.74/22.97)	DLGNLPDLDLGDMG.GMGIDM...D
 1029- 1045 (34.23/17.56)	DMGGGGG...GD.D.DWGLDF...D
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.10|      16|      27|     935|     954|       2
---------------------------------------------------------------------------
  935-  954 (22.77/25.33)	NIADMQSQSisehLNRAMDD
  963-  978 (28.32/18.52)	DISNMDNKA....LQRSMDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.78|      20|      27|      85|     104|       4
---------------------------------------------------------------------------
   85-  104 (32.24/21.24)	LLYSKVRLPIKTEEKPSKDV
  115-  134 (33.54/22.37)	LVFHRLHKVFAAEERPVNNV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     414.33|     134|     149|     313|     457|       6
---------------------------------------------------------------------------
  313-  457 (207.56/164.39)	KLEPQNMATDLITAAfdiLANAMYRNEPTQTLFYLKSF..LINKIPTILTQISGSIFPMTV..EMCitQALS..HVDPNA...FPSFSQgFDDIMGSNNSLSdVRQD..YLNACVLHGLLPAgtveRLLGEAPMQGPPAKRYER..KELLNQCKSNFD
  465-  611 (206.77/132.97)	ELENLDGNAGAIVAA...VADFISHLCDTQTTMYLKQLccLIFKKPQAMDVMLQFTSPASIlrPLC..QFLEdwHYDSDQgeyQPVYDE.FGAILVLIMAFV.YRYDlvYHDIGISHDTFIA....KLLQRGHHSIPPDELTEEqgRHLGSWLKGLYD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33804 with Med5 domain of Kingdom Fungi
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