<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33800

Description Ubiquitinyl hydrolase 1
SequenceMDDVLNEQFGRVERALTTLVDSIAAYNPATQAAIDLVAADDQLSDGLDQLAKHQANHGRIQTLRAEADALEAQLRDSVRKLAGLRRELFNTPATTFSPESRAVPFDELLQYATNISRYTVPPTYRERVPTTDKDDDDVGSSGAPTNGMNTPAIVPDAVDLPNDSSEAQKGGEDADGAVPDITAEEEEWLRKLKASNLAWYPWPSTEKIRNGILYRLSYWREKGNDLDQFDIPAYLEEQRKKALGNEASLEETPAEPTEEQPHREAARPTRPLSAFTGLDDMDEIKTRKRERDVDPVEKVDEAPAKRRRQSIDDQVKLSKLYVDLAAEEDDVRFEAAKQIIVRFAPDNKPAAKDVEDALVRLIKGLCSQRKAARVGFSLTLTEFLRQIFGEKKSEIEGLELDVASIIKMVEEKTKPKGNVPGKERRDHTIGKLFGFKAIMQSSILIEPQISLESWNKLLDQVYKMARDIPWLREECGMVLVEAVRSLKGQSQYQKCVEELLERLNSFQLISTPEGVAVWLTVKESYPEALPEGVWHAKDPLSKKERSRLAKILKEDFNKTESEAGKKETTKTGTTNPNPSFTWDLAFAEMLRRDEAAKEDAQNKPEFPQFWIDTVDGNLFSSSASHERKAWGFKLLSSMVTRVPDWAVSALFSPNLMRTLINQSKKEDRFLHSAALAALNSVQLRVEQEDGTALPIFVALTSKNGSVEFDRITKTKTLEQILLSADDKSLMKIIRHFRSLILRPDSEDQAVADSRRQAIADLLLSTVKLYKRYEKFNEKTFKKEVVHRQEGRPLDERKSNWLRETLETLVECAYFVPARNAETKKMPLPPVSDRSRTVFQERLSSCLTKLLDVKLGSRADVALLVIDMIKAKSGKSSKLELVLKADPSILSTIKQASATLATISEAGSIAGNEMAAQGFMLLYSLTLLQVYNGEGDAVMMLDDLDASYKAFEASRKASSKKKRSSTPDGQNAFVEIVLSFSGNARTLFRRIGEEAFSIFASEISADGLRSLTDILDTEENLEGQRELFNQGDEDAEEDGSSEDDEDEDEIDSDVEMIDGEGSNDTSESDSSDGDSDSEGNSDSEDDEEDAELTQFDNMLAMTLQTSKPNINDDAAEETSDESDMDDEQMMALDPHLSKIFKERSKTTSKKKEREDAKQNVVQFKSRVLDLLAIYMEKQYSNPLTLDILLPVLRRTRANANKQTADKAAKMLKTFFDTRTKHKAPLPKPENTEPVWELLKGIHEEAKLGNGAKVHADACGSASLHVAKVLVGMDRENYAGVVDIYAETQKQWFADKKSPLQPVLFTQFQNWSVNARQQGKLESSNQPHFFSPYSSLPDMACKHVNASELRPPGPTQSVYREDCTQCFDSIDDPTGLDVCLYCFNGGCTSDRSHALLHVSSTNHPLVLNIKRTRRRVQRDEPPQKMTKLAVAAETESDRYDTTTQVKCYECGVDDVDKSSGKLPDIVDAVLKANTFAKQQEVKAWEQELTACEHTLCLEQDAARQIESQKLGHCSECELNENLWLCLSCGNLGCGRQQFGGVGGNSHGVGHTKSTGHPVAVKLGSLTADGTADIYCYACDEERIDPELPDHLAHWGINIKDRVKTEKSLTEMQVEQNLRWDFAMVTEDGKELQPLFGPELTGLKNLGNSCYLNSTLQALFSMPEFKERYYLPEQAPPDAALPAEDLETQLRKIADGMISGRYSKPDTDVITNEQSPEIPHQRGLAPAMLKHLIGRGHAEFSTMRQQDAFELLLHMLKLISRSQHVAPHKDPVDAFRFVMEQRLQCVGCKRVRYRTDEQENISIPVPIRRIPKESQMDVTDGNGKKEEKEEFEPVSLKECIDIFTAEELVELTCSACGSKDGFTKRSMFKTFPSVLAVNARRFELVNWVPTKQDVPVIVNDEPFSFDAYKSNGLSEGEELLPDDVDMGGAGGSAGKWVPNEAALSMLEAMGFPRVRCEKALHATGNEDAEAASNWLFAHMEDPDIDDPVDFNAGSSGNTAAASAIDPEKIENLGAMGFSAPQARQALKETGGDMERAVDWLFSHPDAPGDFDEGGSSDAPADATEKALAGSDKLPANFQLQSIVCHKGSSIHAGHYVAFVRKQLQNEQSASWVLFNDEKVAKAADVEEMKKFAYVYFFRRL
Length2137
PositionMiddle
OrganismBipolaris zeicola 26-R-13
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Bipolaris.
Aromaticity0.07
Grand average of hydropathy-0.564
Instability index46.89
Isoelectric point4.99
Molecular weight238374.96
Publications
PubMed=23357949

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
nucleolus	GO:0005730	IEA:InterPro

GO - Biological Function
DNA binding	GO:0003677	IEA:InterPro
thiol-dependent deubiquitinase	GO:0004843	IEA:UniProtKB-EC
transcription coregulator activity	GO:0003712	IEA:InterPro
transcription factor binding	GO:0008134	IEA:InterPro
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process
protein deubiquitination	GO:0016579	IEA:InterPro
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
ubiquitin-dependent protein catabolic process	GO:0006511	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33800
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     106.37|      20|      21|     223|     242|       1
---------------------------------------------------------------------------
  171-  192 (26.30/13.77)	GEDADGAvpDITAE.EEEW..LRKL
  194-  210 (22.93/10.93)	ASNLAWY..PWPS..TEKI..RN..
  223-  242 (35.01/21.09)	GNDLDQF..DIPAY.LEEQ..RKKA
  244-  266 (22.13/10.26)	GNEASLE..ETPAEpTEEQphREAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     255.33|      59|     326|    1263|    1338|       2
---------------------------------------------------------------------------
 1267- 1325 (99.26/60.79)	VLVGMDRENYAG.VVDIYAETQKQWF..ADKKSPLQPVLFTQFQNWSVNARQQGKLE..SSNQP
 1342- 1402 (82.70/69.62)	..VNASELRPPGpTQSVYREDCTQCFdsIDDPTGLDVCLYC.FNGGCTSDRSHALLHvsSTNHP
 1556- 1605 (73.37/36.18)	VAVKLGSLTADG.TADIYC......Y..ACDEERIDPELPDHLAHWGINIKDRVKTE..KS...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.94|      45|     327|     611|     666|       3
---------------------------------------------------------------------------
   87-  134 (74.22/44.23)	ELFNTPAttfSPESRAVPFDELLQYATNISRYTV.....PPTYRERVPTTDKD
  617-  666 (72.73/54.47)	NLFSSSA...SHERKAWGFKLLSSMVTRVPDWAVsalfsPNLMRTLINQSKKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      95.93|      16|      17|    1031|    1046|       5
---------------------------------------------------------------------------
 1015- 1030 (20.19/ 8.32)	DTEENLEGQRELFNQG
 1031- 1046 (28.34/15.26)	DEDAEEDGSSEDDEDE
 1073- 1088 (24.28/11.80)	DSDSEGNSDSEDDEED
 1110- 1125 (23.13/10.82)	NDDAAEETSDESDMDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.37|      12|      44|     793|     806|       6
---------------------------------------------------------------------------
  795-  806 (21.93/14.35)	ERKSNWLRETLE
 1966- 1977 (24.44/ 9.32)	EAASNWLFAHME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      77.62|      21|      21|     375|     395|       8
---------------------------------------------------------------------------
  375-  391 (20.67/ 9.52)	.....GFSLTLTEFLRQIFGEK
  392-  412 (23.48/11.80)	KSEIeGLELDVASIIKMV.EEK
  416-  436 (33.47/19.91)	KGNV.PGKERRDHTIGKLFGFK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.81|      16|      21|     279|     294|       9
---------------------------------------------------------------------------
  279-  294 (26.81/19.53)	DDMDEIKTRKRERDVD
  297-  312 (26.00/18.65)	EKVDEAPAKRRRQSID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     148.63|      47|     466|    1404|    1481|      10
---------------------------------------------------------------------------
 1435- 1481 (81.69/78.01)	DRYDTTTQVKCYECGVDDVD.....KSSGK.LP.DIVDAVLKANTFAKQQEVKA
 1903- 1956 (66.94/24.28)	DAYKSNGLSEGEELLPDDVDmggagGSAGKwVPnEAALSMLEAMGFPRVRCEKA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.44|      15|      26|     567|     582|      14
---------------------------------------------------------------------------
  567-  582 (26.23/20.10)	ETTKTGTTN.PN.PSFtW
  594-  610 (21.21/10.31)	EAAKEDAQNkPEfPQF.W
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     175.66|      54|     276|    1498|    1555|      15
---------------------------------------------------------------------------
 1498- 1555 (86.20/63.15)	DAARQIESQKLgHCSEC.......ELNENLWLCLSCGNLGcGRQQFGGVGGNshGVGHTKSTGHP
 1770- 1830 (89.46/50.35)	DAFRFVMEQRL.QCVGCkrvryrtDEQENISIPVPIRRIP.KESQMDVTDGN..GKKEEKEEFEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.38|      31|     276|    1702|    1747|      17
---------------------------------------------------------------------------
 1215- 1255 (40.08/16.53)	DTRTKHKAP.LPKPENTEPVweLLKGIheeakLGNGakvHAD
 1705- 1736 (52.30/53.00)	DVITNEQSPeIPHQRGLAPA..MLKHL.....IGRG...HAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     171.44|      56|     380|    1640|    1699|      20
---------------------------------------------------------------------------
 1640- 1699 (90.51/53.48)	LKNLGNScyLNSTLQALFSMP....EFKERYylPEQAPPDA...ALPAED...LETQLRKI....ADGMISGRY
 2023- 2092 (80.93/37.60)	LKETGGD..MERAVDWLFSHPdapgDFDEGG..SSDAPADAtekALAGSDklpANFQLQSIvchkGSSIHAGHY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33800 with Med4 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KKALGNEASLEETPAEPTEEQPHREAARPTRPLSAFTGLDDM
2) SLTDILDTEENLEGQRELFNQGDEDAEEDGSSEDDEDEDEIDSDVEMIDGEGSNDTSESDSSDGDSDSEGNSDSEDDEEDAELTQFDNMLAMTLQTSKPNINDDAAEETSDESDMDDEQMMALDPHLSKIFKERSKTTSKKKEREDAKQN
3) VPPTYRERVPTTDKDDDDVGSSGAPTNGMNTPAIVPDAVDLPNDSSEAQKGGEDADGAVPDITAEEE
240
1009
120
281
1158
186










Molecular Recognition Features






MoRF SequenceStartStop




1) EQMMA
2) GILYRLSYWR
1126
211
1130
220