<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33798

Description FCH and double SH3 domains protein
SequenceMENCKYICCDINRFMGATRSPWTGAFQPPISDPPLPKEQNRHLEELLNTAFSYYVKSYYYSPDTVTSVYCLGRDVGTLVCALIKSPLVDIVYLIDVKKSVGSAIYSLSVVYAIKLMKDDFSDRGINDLCFCFYLRQNRSEELKVSANVNESHVRNIGVLIEAHSQRLEGHLRTCEHLSRWAASNIRDVRRIRLLLMSLLDRPATDPEADTQEVGRQSDVGAELNDIEVSIRKMKSLVDSLDKSATKSKKQMDSRSMLPYNLVLPLDQMDVQMESGDSLRRVDWLVGRNEACRWLRRTNYRTEAIQLSLASCGRFMRNTTLVPLSSGMDLRNLAAPQMSFALIESNSRNPILYVKVGDIMHCLITFGNLCMENIIIRGLDESHYASGHTLRPQAANPGTFPRISQAMSDLLYSRAISGFSTNLLPNVDTMPEGLPPTASQLDLTTPSRHVTFVRVTEAARNALVHFATTTEPPTQLSALHQFCDWLQTYTRLFTEPCVNCDQLLGQDAALPVLRTFHTNPANARAQHEQCRKFIGVYYLVSARNKILCLGLDWWDRCIKVVMQASTKKPQSQLKYIQSEHFSRLLSKQNNETELLEDMRSFCKQRAILDKEYGQALQKLCSSFLSKKEFLALPNPPNTGHRSVWDIWKLFLQEFNALALSHLKLAEIHHRLSLELKPVKSLRVAVSKRIFEQLKSLQNDLAASMQEMVKSQKIYSEEEKQAHETRLKAMNIEDKLRRRSTNLFSTMAQLHRNHAKISQRRDEYENRSAGARNEYLFQLTAINAHLDHYLKTDIPDLAQILDGDVYDRFREVLYKTSEMELEICRHHQDPLKALLEESTKINRKTAWENFIKELPIFSADVEFHFEPRDGDTISSLLSVNAKEGSFEQVAKKLARRFVTRERRIKSYRQEINDLCSGRISPSPGMSVSLSQDCDTSEDSGALNQEYVENKVEELEFAIRREEIEKTKISACLELLKKTHVDVQAALYEANLAATEVRTGTVGRGMEVAEKAQHGASSSSTAATGSSSTEGSTVGLTGLLTDSTKHRNSFLLENAFAPLNSSIPRSRTQNGGISRTSAQQLANEAWARANATSPGANDEPSFIQLDDEDPPSQQQPSRREPSPEVDWTGGGQLPKATAMYEFLAARSDEINMVCNERVVLLGAGDGEDWRDYVNVSCSIKNSCKQTTILVYSNAYQIDGYATEVLRYGFCTARSVRSLLDGKAGLVPRAFLSIDPTPPPAPPHPAVPALAVKSDTEQEPSDKTPLSPTSPPSEPVAPPHPPMEQCLAGQFVRALIDFAGTAEDELSFGVGAVIHVLGRPAVGEVDDGWIEGELVPLTDAETTTPPACGVFPSMLVEAVTPDDIWQRRLSACRPRPAKALLSTGSTADAKVSPSGERRCKPLSSSGSVPSPRLSNSASRSKSRSASAKRSWGGGASGGPRRSTVSHNTSSSHRSSHHQQQQQQQHHGQQGRETSTGHGRVSRSLVAAKVTPSQASPPSAEAHPPASTHQQQEPSPFIPNEEGRISPNQTYGNEEVRCFPTVS
Length1538
PositionTail
OrganismEchinococcus granulosus (Hydatid tapeworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Cestoda> Eucestoda> Cyclophyllidea> Taeniidae> Echinococcus> Echinococcus granulosus group.
Aromaticity0.06
Grand average of hydropathy-0.464
Instability index56.05
Isoelectric point7.00
Molecular weight171143.38
Publications
PubMed=24013640

Function

Annotated function 
GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-KW
F-actin capping protein complex	GO:0008290	IEA:InterPro
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
actin binding	GO:0003779	IEA:UniProtKB-KW

GO - Biological Process
barbed-end actin filament capping	GO:0051016	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33798
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.70|      30|      31|    1363|    1393|       1
---------------------------------------------------------------------------
 1363- 1393 (46.21/32.04)	RRLSACRPRPAKALLSTGSTADAKvSPSGER
 1396- 1425 (48.49/29.21)	KPLSSSGSVPSPRLSNSASRSKSR.SASAKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.44|      26|      31|     998|    1025|       2
---------------------------------------------------------------------------
  998- 1024 (39.20/29.21)	TVG.RGMeVAEKAQHGAS...SSSTAATGSS
 1030- 1059 (35.24/16.53)	TVGlTGL.LTDSTKHRNSfllENAFAPLNSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     120.48|      30|      34|    1214|    1247|       3
---------------------------------------------------------------------------
 1214- 1244 (53.59/27.45)	SLLDGKaGLVPRAFLSIDPT.....PPP....APPHPAV.P
 1250- 1281 (41.66/19.65)	SDTEQE....PSDKTPLSPT.....SPPsepvAPPHPPMeQ
 1474- 1500 (25.23/ 7.79)	.......GRVSRSLVAAKVTpsqasPPS....AEAHP...P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     113.04|      30|      40|     421|     450|       4
---------------------------------------------------------------------------
  396-  416 (20.80/ 7.36)	.........P.GTFPRI.SQA..msD.LLY.SRAIS
  421-  450 (57.06/32.78)	NLLPNVDTMPEGLPPTA.SQL....D.LTTPSRHVT
  460-  493 (35.18/17.44)	NALVHFATTTE..PPTQlSALhqfcDwLQTYTRLFT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.09|      28|      40|     780|     819|       5
---------------------------------------------------------------------------
  780-  807 (47.98/50.58)	INAHLDHYLKTDIPDLAQILDGDVYDRF
  821-  848 (49.11/26.11)	ICRHHQDPLKALLEESTKINRKTAWENF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     158.48|      50|     783|     123|     175|       7
---------------------------------------------------------------------------
  123-  175 (81.94/58.62)	RGINDLCFCfylRQNRSEELKVSANVNESHVRNIGVL....IEAHSQRLEGHLRTCE
  907-  960 (76.54/46.57)	QEINDLCSG...RISPSPGMSVSLSQDCDTSEDSGALnqeyVENKVEELEFAIRREE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     229.34|      70|     223|     282|     351|       9
---------------------------------------------------------------------------
  282-  351 (122.99/75.92)	DWLVGRNEACRWLRRTNYRTEAIQLSLASCGRFMRNTTLVP.....LSSGMDL..RNLAA........PQMSFALIESNSRNPIL
  500-  584 (106.35/64.64)	DQLLGQDAALPVLRTFHTNPANARAQHEQCRKFIGVYYLVSarnkiLCLGLDWwdRCIKVvmqastkkPQSQLKYIQSEHFSRLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.89|      20|      32|    1144|    1163|      11
---------------------------------------------------------------------------
 1144- 1163 (34.70/29.97)	SDEINMVCNERVVLLGAG....DG
 1173- 1196 (30.18/24.80)	SCSIKNSCKQTTILVYSNayqiDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.67|      36|      40|     688|     724|      13
---------------------------------------------------------------------------
  688-  724 (52.65/44.56)	IFEQLKSLQNDLAASMQEMVKSQKIYSeEEKQAHETR
  730-  765 (59.02/44.88)	IEDKLRRRSTNLFSTMAQLHRNHAKIS.QRRDEYENR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33798 with Med27 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PPHPAVPALAVKSDTEQEPSDKTPLSPTSPPSEPVAPPHPPM
2) RPAKALLSTGSTADAKVSPSGERRCKPLSSSGSVPSPRLSNSASRSKSRSASAKRSWGGGASGGPRRSTVSHNTSSSHRSSHHQQQQQQQHHGQQGRETSTGHGRVSRSLVAAKVTPSQASPPSAEAHPPASTHQQQEPSPFIPNEEGRISPNQTYGNEEVRCFPTVS
3) SSIPRSRTQNGGISRTSAQQLANEAWARANATSPGANDEPSFIQLDDEDPPSQQQPSRREPSPEVDWTGG
4) TGTVGRGMEVAEKAQHGASSSSTAATGSSSTEGSTVGLTGLL
1238
1371
1058
996
1279
1538
1127
1037










Molecular Recognition Features






MoRF SequenceStartStop




NANANA