<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33794

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDRTHPTSFQARPPSPSSPAGSLKENIRFPISSDHIPQTPISPPLMSVSEPSHAANFISSPNQATVHSPNISPPSSAPMSTQVSQQPTMSTTNAFPTPASSVSGHPTANSDDVDQGRKSFNMGMQDSAENSGASPAQQSTQHRPTDHDRQSFQTDSTDFATGQGQHSTDSDAMDMNKGSTRADTLSLDLDSLQKELTSAFHLCKRSPIVTGPDPTVDLVSLYGLGPIAHSVARMDPVTGEKINRLRKSYEGKLKGLGLSGRNKPVKKEIGTPGSLRYMTLWPEEEWQNQKVHGKAIKVSDMDSALQNLQSRAMQMEPGPIPNNDFWEDILGHEKAAKNPAPGELGKKAPPAPAGRFSSQSYVPSPQPQEADRPRPSRGRKRHYDDNSFAGYGEGFVDDDDDPGFYSNGEGTGKKKRKKGHVAKVSTPMSERSASYGVGMFGIGAR
Length446
PositionHead
OrganismPenicillium roqueforti (strain FM164)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.06
Grand average of hydropathy-0.867
Instability index57.49
Isoelectric point7.27
Molecular weight48058.59
Publications
PubMed=24407037

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP33794
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.86|      27|      27|     166|     192|       1
---------------------------------------------------------------------------
  138-  164 (43.81/26.70)	QQSTQHRPTDHDRQS...FQTDSTDFATGQ
  166-  192 (44.49/27.24)	QHSTDSDAMDMNKGS...TRADTLSLDLDS
  194-  221 (35.56/20.27)	QKELTS.AFHLCKRSpivTGPDP.TVDLVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.31|      27|      31|      14|      43|       2
---------------------------------------------------------------------------
    2-   27 (31.75/10.15)	....SDrtHPTSFQAR.....PPSPSSPAGSLKEN
   30-   57 (44.15/23.17)	FpISSD..HIPQTPIS.....PPLMSVSEPSHAAN
   58-   85 (34.41/ 9.62)	F.ISSP..N..QATVHspnisPPS.SAPM.STQVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     147.50|      34|      34|     309|     342|       3
---------------------------------------------------------------------------
  277-  306 (32.75/11.94)	...RYMTLWP.....EEEWQNQKVHGKAIKvsdmDSAL
  309-  342 (62.12/28.37)	LQSRAMQMEPGPIPNNDFWEDILGHEKAAK....NPAP
  345-  376 (52.63/23.06)	LGKKAPPAPAGRFSSQSYVPSPQPQE..AD....RPRP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33794 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSDRTHPTSFQARPPSPSSPAGSLKENIRFPISSDHIPQTPISPPLMSVSEPSHAANFISSPNQATVHSPNISPPSSAPMSTQVSQQPTMSTTNAFPTPASSVSGHPTANSDDVDQGRKSFNMGMQDSAENSGASPAQQSTQHRPTDHDRQSFQTDSTDFATGQGQHSTDSDAMDMNKGSTRADTLSLDLD
2) VHGKAIKVSDMDSALQNLQSRAMQMEPGPIPNNDFWEDILGHEKAAKNPAPGELGKKAPPAPAGRFSSQSYVPSPQPQEADRPRPSRGRKRHYDDNSFAGYGEGFVDDDDDPGFYSNGEGTGKKKRKKGHVAKVSTPMSE
1
292
191
431










Molecular Recognition Features






MoRF SequenceStartStop




1) FWEDILG
2) GEGFV
3) KKKRKKGHVAKVST
4) NIRFPIS
5) YMTLW
326
393
414
27
278
332
397
427
33
282