Description | Mediator of RNA polymerase II transcription subunit 7 |
Sequence | MADESQQRAVTTAFAPPPPLWKHFTRENIDKLEQIKAEASKGEDGRLNKHKQWSAAELRALELPSELRYLVPPDIPEGQYSVFGELQTLSTTLPSLQEQGIEQLYPEPPAAGTDQNSQPSPPLNHAYYLLKISKSLLLNFLEFTGILSVSPEQFESKVEDLRNLFINAHHLLNLYRPHQARESLIMMMEEQLNHSREEMKQMDKVKAEVESVLEQLQAEGSRMATTGSGDDTDQAKALKEKADEHSRLIWALLDKEN |
Length | 257 |
Position | Middle |
Organism | Penicillium roqueforti (strain FM164) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.663 |
Instability index | 50.98 |
Isoelectric point | 5.06 |
Molecular weight | 29169.51 |
Publications | PubMed=24407037 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery.
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364060 ECO:0000256 ARBA:ARBA00003669 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP33793 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 98.04| 31| 179| 32| 62| 1 --------------------------------------------------------------------------- 32- 62 (51.97/31.02) LEQIKAEASK.GEDGRLNKHKQWSAAELRALE 213- 244 (46.06/26.84) LEQLQAEGSRmATTGSGDDTDQAKALKEKADE --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 61.89| 18| 43| 90| 107| 4 --------------------------------------------------------------------------- 90- 107 (31.84/20.01) STTLPSLQEQGIEQLYPE 135- 152 (30.05/18.53) SLLLNFLEFTGILSVSPE --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) ALKEKADEHSRLIWALLDK 2) PLWKHFTRENIDKLEQIKA | 237 19 | 255 37 |
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