<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33788

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGANTNIHLIDGFSNIYWRIYTEEAGITNNPQESPANGYTILKHLSRLKDLEARLRGLNCLASCPRRLGLWVFSPTPEFESLKPLYVRGSDTESNKIVVGTTTLKVSALGSVSSLDLVKGLSSDNQSQNGTQPAAQPRPHQSQPTSRRQDGYSSSAAIYASFVSAVTGSISLQLIRRHGALPLGSRTLFTAIEKSGYESPHINNESILSTSCLTTLNVQLTISGTITVSAQTVSQTGITRLCSPRDDISKITDVQPGIDLWLCPSGTIARLVTANIDSPTVPSLGHPTPGNLSAKRIQWKLDVVQWLRNFGLHVDSIDEEPWVEVEVWEPFFARLAGEAWRQSDDSQSALPLKRMLWPARFCFRRASSSNFSSDAQTSLLDEPLDFAEQWSTMASSLKLDHISHIAQNTPTTQDSRPKDQEMASPPKAEPLETTESLSRIAQYPDLQTMNLVYPTPPDGAAAVGLNNPNPPEAFADDSDFGLPHATQRNSRRNVPGSDISPVQNSGVGIGTGRYDASDEEDLFGEMNERDFGSKGITDADFSFFDDPDFDGMEGDSRVEDADEAVEAPRPQSESEAEAMVDAELSPNQSREIPTHLETHEVHASPIHHESPQLSERPMAPEESAHSPMDRAGQTISPPLSPVEVKKILFPGSEADDRRQPTGHRGQGHYHPVAFEKKLGDWDRKYGAAGKFWFSGGNSLDTLNQTSAIPTIGIPRRDRSNANVPSSKERNKTSLSLIQSENGLRSASVSSDSSDDSIEIMSEHVPTPAAMPSIPSLKRKRAPSESDIMSVASQEKSFPGTEANPAYAAENSTFLGNFLANFSDWTLTGYFSAFPPQQLPVLPRHEGQLEIAQLLVDQITQSSLKHPLDGKIGLFDLESESLSLQALDDTALLGETSRMDFKKYTSFQDEFVANLPQQQPPQHQALPKDPPKSFISKLSAPHIRVRRGKEYLEALPPAVSFWETFGLEPAHGPKNISAYCIHPPAASTAADVFLRRFGLLYQSCSLGTHTRGDDSVAFEEGLKLWKSETSSYESMMQVLKRTCEQLGSELSQSTATADNHVVYIINPFTHAAALADICSAFWYLFQQLVAGSERRQTRIANELVLQIIPLEFVMSSETMVIPPQVDYLNLALEVYSRCRSNDAEMSPLLCAPPMLLADAIPRAISFRLAPERSSPLQDGRSLHIAYSKSLDQRWISVAWSDLPGSIQRTMSYCLRYRQSGGTRPVSEVRNEIWATTKHIMEKFQARWKVQLATTEPMETEEVEAWASLADQHNKSKPGSLELTILAVNTVPDLILEPPVPPVSMAMLNILSSSTPVSTPNPNASVASPEQSGNAATPTSAGPAAYSAPTPTDMSLETDSETVLTDICDDSWLAILSHRLNSSPHLTEFRPALSSGYLLRRKGTTDADGVFATSVNLIYSPRIPVSHDSVLKDTLSMYRDLGCLARAKGICSVQNNTLPWHVATALRAQELLSYVF
Length1478
PositionKinase
OrganismPenicillium roqueforti (strain FM164)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.393
Instability index58.56
Isoelectric point5.21
Molecular weight162057.54
Publications
PubMed=24407037

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33788
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     269.89|      80|     611|      27|     207|       1
---------------------------------------------------------------------------
  124-  204 (132.43/61.22)	GLSSDNQSQNGTQPAAQPRPHQSQPTSRRQDGYSSSAAIYASFVSAVTG....SISLQLIRRHGALPLGSRTLfTAIEKSGYESP
  468-  551 (137.46/43.38)	GLNNPNPPEAFADDSDFGLPHATQRNSRRNVPGSDISPVQNSGVGIGTGrydaSDEEDLFGEMNERDFGSKGI.TDADFSFFDDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     567.43|     189|     549|     581|     811|       2
---------------------------------------------------------------------------
  581-  811 (276.39/230.86)	EAMVdaelSPNQSREIPTHLETHEVHASPIHHESPQLSERPM..............APEESahSPMdRAGQTI....SPPLSP..VEVKKILFPGSEADD......RRQPTGHRgqghyhPVAfEKKLGDWD......RKYGAAGKFWFSGGNSLDTlNQTSAIPTIGiprrDRSNANVPSSKERnkTSLSLiqsenglrsasvssdssdDSIE..IMSEHVPtPAAMPSIPSLKRKRAPSESD.IMSVASQEKSfpGTEANPAYA
 1120- 1343 (291.05/158.64)	ETMV....IPPQVDYLNLALEVYSRCRSNDAEMSPLLCAPPMlladaipraisfrlAPERS..SPL.QDGRSLhiaySKSLDQrwISVAWSDLPGSIQRTmsyclrYRQSGGTR......PVS.EVRNEIWAttkhimEKFQARWKVQLATTEPMET.EEVEAWASLA....DQHNKSKPGSLEL..TILAV..................NTVPdlILEPPVP.PVSMAMLNILSSSTPVSTPNpNASVASPEQS..GNAATPTSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     328.35|     101|     544|     348|     467|       3
---------------------------------------------------------------------------
  348-  467 (159.13/99.11)	DDSQSALPLKRMLWPARFCFRRASSSNF..SSDAQTSLL..DEPLDFAEQWStmasslkldhishiaqnTPTTQDSRPKDQEMASPPKAEPLETTeSLsRIAQYPDLQTMNLVYPTPPDGAAAV
  891-  995 (169.22/77.57)	DDTALLGETSRMDFKKYTSFQDEFVANLpqQQPPQHQALpkDPPKSFISKLS.................APHIRVRRGKEYLEALPPAVSFWETF.GL.EPAHGPKNISAYCIHPPAASTAADV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.07|      19|    1379|      48|      66|       8
---------------------------------------------------------------------------
   48-   66 (34.25/23.47)	HLSRLKDLEARLRGLNCLA
 1429- 1447 (35.82/24.88)	HDSVLKDTLSMYRDLGCLA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33788 with Med13 domain of Kingdom Fungi
Unable to open file!