<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33787

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMADSFTLPLRPIPEKRERPDTLPVEIAQINNQWGSFREVNEDVLRNKIAEEEEKDGLDEVDESDQDATDLDSTERLEQLYKRRAEITQFAMQAHMETMFALDFVSLLLSKQAPRQAETSMSAFLKQVAPLGSLNAEVVNPPPKPESTIKDISAVSRGWRIQNFNAAANKLLQAASRLETEVASETRYWNEVLAVKDKGWKISRLPRERQSLGVQYGFLEATPVFRNRGLASLRRAEDGALLLDEGLIPSKARFVRVRVIQDGKLSGRSRPTRSTFNGNATIEDRILQARDTVYEEELFHELVREARAIASFGVTTRQNLIQIPASDNLEILLDLVDTDEDTSQPEHDISQQGTSLADGLAHTIRILLAYAHRQNLRRRTMLPLPLTPKTRPVPEHQLIRPALAYIKHMSDVRWLQSLLKDLFGVLQSAGLKPPAYTARVFSTKRQKQTSSAPVVETLIGQFLTPLLSTFHGKLLTPRGSFSIAIHTNLSSTPFGTTFDVSFNMPKYPDLESPGKLSQREEVEAAINHLLLLDVVFTISSNSGSLKSESDKDQAKGSWEAIYPQHGELLIPSSKSESRKKMKIALSRHELSVEIYSVRCIDGTGRGNWEKPSSHSMPHIWKPSPIAGSPNQPSLMDFVSAAVSR
Length643
PositionHead
OrganismPenicillium roqueforti (strain FM164)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.06
Grand average of hydropathy-0.430
Instability index50.93
Isoelectric point6.74
Molecular weight72006.85
Publications
PubMed=24407037

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33787
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.98|      46|      46|     303|     348|       1
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  303-  348 (74.98/44.30)	REARAIASFGVTTRQNLIQIPASDNL..EILLDLVDTDEDTSQPEHDI
  350-  397 (73.00/42.95)	QQGTSLADGLAHTIRILLAYAHRQNLrrRTMLPLPLTPKTRPVPEHQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.26|      38|      39|     447|     485|       2
---------------------------------------------------------------------------
  447-  485 (61.73/59.70)	QTSSAPVVETLIGQFLTPLLSTFH..GKlLTPRGSFSIAI.H
  487-  527 (56.53/48.35)	NLSSTPFGTTFDVSFNMPKYPDLEspGK.LSQREEVEAAInH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.37|      24|      27|     175|     201|       3
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  175-  198 (40.82/26.92)	SRLETEVAS.ETRY.WNEVLAV.KDKG
  202-  228 (29.54/10.58)	SRLPRERQSlGVQYgFLEATPVfRNRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.19|      28|      28|      91|     118|       4
---------------------------------------------------------------------------
   82-  113 (39.95/23.90)	RRAEItqfaMQAHMETMFALDFVSLLLSKQAP
  114-  142 (42.24/25.64)	RQAET...sMSAFLKQVAPLGSLNAEVVNPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.06|      25|     110|     148|     173|       5
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  148-  173 (40.56/30.63)	IKD..ISAVSRGWRiQNFNAAA...NKLLQA
  259-  288 (35.51/21.68)	IQDgkLSGRSRPTR.STFNGNAtieDRILQA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33787 with Med17 domain of Kingdom Fungi
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