<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33787
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MADSFTLPLRPIPEKRERPDTLPVEIAQINNQWGSFREVNEDVLRNKIAEEEEKDGLDEVDESDQDATDLDSTERLEQLYKRRAEITQFAMQAHMETMFALDFVSLLLSKQAPRQAETSMSAFLKQVAPLGSLNAEVVNPPPKPESTIKDISAVSRGWRIQNFNAAANKLLQAASRLETEVASETRYWNEVLAVKDKGWKISRLPRERQSLGVQYGFLEATPVFRNRGLASLRRAEDGALLLDEGLIPSKARFVRVRVIQDGKLSGRSRPTRSTFNGNATIEDRILQARDTVYEEELFHELVREARAIASFGVTTRQNLIQIPASDNLEILLDLVDTDEDTSQPEHDISQQGTSLADGLAHTIRILLAYAHRQNLRRRTMLPLPLTPKTRPVPEHQLIRPALAYIKHMSDVRWLQSLLKDLFGVLQSAGLKPPAYTARVFSTKRQKQTSSAPVVETLIGQFLTPLLSTFHGKLLTPRGSFSIAIHTNLSSTPFGTTFDVSFNMPKYPDLESPGKLSQREEVEAAINHLLLLDVVFTISSNSGSLKSESDKDQAKGSWEAIYPQHGELLIPSSKSESRKKMKIALSRHELSVEIYSVRCIDGTGRGNWEKPSSHSMPHIWKPSPIAGSPNQPSLMDFVSAAVSR |
Length | 643 |
Position | Head |
Organism | Penicillium roqueforti (strain FM164) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.430 |
Instability index | 50.93 |
Isoelectric point | 6.74 |
Molecular weight | 72006.85 |
Publications | PubMed=24407037
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP33787
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 147.98| 46| 46| 303| 348| 1
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303- 348 (74.98/44.30) REARAIASFGVTTRQNLIQIPASDNL..EILLDLVDTDEDTSQPEHDI
350- 397 (73.00/42.95) QQGTSLADGLAHTIRILLAYAHRQNLrrRTMLPLPLTPKTRPVPEHQL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 118.26| 38| 39| 447| 485| 2
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447- 485 (61.73/59.70) QTSSAPVVETLIGQFLTPLLSTFH..GKlLTPRGSFSIAI.H
487- 527 (56.53/48.35) NLSSTPFGTTFDVSFNMPKYPDLEspGK.LSQREEVEAAInH
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 70.37| 24| 27| 175| 201| 3
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175- 198 (40.82/26.92) SRLETEVAS.ETRY.WNEVLAV.KDKG
202- 228 (29.54/10.58) SRLPRERQSlGVQYgFLEATPVfRNRG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 82.19| 28| 28| 91| 118| 4
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82- 113 (39.95/23.90) RRAEItqfaMQAHMETMFALDFVSLLLSKQAP
114- 142 (42.24/25.64) RQAET...sMSAFLKQVAPLGSLNAEVVNPPP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 76.06| 25| 110| 148| 173| 5
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148- 173 (40.56/30.63) IKD..ISAVSRGWRiQNFNAAA...NKLLQA
259- 288 (35.51/21.68) IQDgkLSGRSRPTR.STFNGNAtieDRILQA
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