<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33785

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMIPHSSAGGQPWGHPLRTFNGGLGRVDNAQMLGQYDQPNRSASLPQPPIRQPAVVDLTAGGPESQDREPPPKRPRLEVPSRSNTSDTGLAVGETKNNPGSVISRPAASWRGRPVWSFQALVSEIPSNENRGDGAALKPPSPPPLPAQPWMNNFVPEPEGSATVKSRESSPVGAVQTTPYRIEIPAVAPLYKDHKPADFAPWTGNHPEDVLSEQTTKQGYYDRTQVSQNESNTARPALYAQLKNRTGLQMLSSVFAAALEKRQSHNTIHAPSTFKPPPRVTLTDNKREAWLRDLANPSVPLRRLSRTIPHGIRGKVLLDQCLGKCIPVARAVWLAKCVGANEIRAFKRKGTSGALAVGLEAKWVRDWTTNVQQFVEGVCTATKSPDWKAKMTYAVGLTARLFSENLLDHDHFLEWFLSSFEAASIVTIPIWLLMLGIYWKNIMRYRRRGRRLAELLLHKVRQATEAKLTQLQPLIDRLFRFIKKLVLDHTSSMILPNSWDTYKQQVLSALDLGNEAEKALFQSLAERNARVQRPRHSKQTTQRSPHQHIVRLLDSIRFSHDLPSIFDYLNAFDDKAVLVFKLLEWLSTPFRYGLCRVYIGVRLLRKWKLAGVDVDSHILAFLSSGQNNQKLNVDQIYHVVSELVRSQTFSVGRYLQWLMARGVTNGSSSAEDPKAKNLPIDIGLIAQLPVARLPEHVGNLRSTLLNRTGLSASGENAAIESVKDIISQRLPGIFGVQESTSMEFESLPTNLPWAVKADVGQWLRRAVAEHNRSTEGVFPIGNTSVVSALTPAEFYTVRDALETFGDISMLADVLKFASSCGDSTVLASVADTTNCHFDSLCIIGATTDLFRRLIDAYAGMKRFGMPSLDLIFSLIELGLRIPSELNTVSILRQDLSRMENRSMVAASSPVSDHIPDDFDGVDSFFREKLDQLLHSGNVMDEPTLDTIFTTLIKHLESDNGDTNLSANDACRYLAQLRSFHPKHFDGMLARWVCGHLRSPERTVLLRILPPLIGVGCVTIRAFLALAKRLALSKPAIVPNAAQLPAELVQLLVSGEDSKSFDLVSYRFQLAQQEFLNKDSEEALKIVCDAASSNAVGSFTGHTELEHSMVMLLRDLLVRHPECAAQNSMQKLIDQYPAALGVVQKALDLLLGIESQSDGKSVLSKVEKLARMTDDFSLPFCQLKLQVLFHADSGSEDRTNIVDAMFKTAVSDCRAHRLHWIDLVALMSPDAVRQIRERAEKAFFSIPLLEEPLGDIPDLPDKLGSLETAKMYLTIIEELASSIPDSGAPSVAPVLVEKMDALLHKIITLHNSTLRGVGVANTARANFERALAFWFSALLRMIVLHRSAFAQPPPALKINPLHEQLRLLTSIFCIALSSLPGDVLRLFPAADYFPHPTPAEGFRPCPGILLQTHALDVAASLIDIFPDEVRHQCARFLKEKCPFFAPFQNDSRFLYLLGPISEQYPANSQQVSAPSPAGLGSTAVAAAPGLPTGQSDSNCMASRLRLQRRGRVAGPYPVRPWELLEDAAPFLGVNDTAVNLGFFDARRVRA
Length1548
PositionKinase
OrganismPenicillium roqueforti (strain FM164)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.157
Instability index47.60
Isoelectric point8.60
Molecular weight171228.29
Publications
PubMed=24407037

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP33785
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.88|      19|      74|      56|      79|       1
---------------------------------------------------------------------------
   56-   77 (30.84/16.69)	DLTAGGPESqdrEPP.PKRPRLE
  132-  151 (34.04/11.78)	DGAALKPPS...PPPlPAQPWMN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.86|      27|      74|     848|     875|       2
---------------------------------------------------------------------------
  848-  875 (43.76/27.91)	LFRRLIDA..YAGmKRFGMPSLDLIF.SLIE
  923-  952 (40.10/20.88)	FFREKLDQllHSG.NVMDEPTLDTIFtTLIK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.15|      32|      74|     661|     695|       3
---------------------------------------------------------------------------
  661-  695 (50.17/43.77)	GVTNGSSSAEDPKAKNLP....IDIGLIAQLPVArlpEH
  734-  769 (51.98/35.71)	GVQESTSMEFESLPTNLPwavkADVGQWLRRAVA...EH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     163.11|      45|      74|     248|     292|       4
---------------------------------------------------------------------------
  193-  221 (24.92/ 9.12)	........................HKPADFA.PwtgnHPEDVLSEQTTKQGYYD
  248-  292 (78.32/44.16)	QMLSSVFAAA....LEKRQSHNTIHAPSTFK.P....PPRVTLTDNKREAWLRD
  319-  365 (59.87/32.05)	QCLGKCIPVAravwLAKCVGANEIRA...FKrK....GTSGALAVGLEAKWVRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.19|      22|      79|     387|     408|       5
---------------------------------------------------------------------------
  387-  408 (38.42/24.71)	KAKMTYAVGLTARLF...SENLLDH
  464-  488 (32.77/19.97)	EAKLTQLQPLIDRLFrfiKKLVLDH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     335.88|     106|     115|    1063|    1177|       6
---------------------------------------------------------------------------
 1067- 1177 (160.82/114.77)	QLAQQEFLNKD..SEEALKIVcDAASSNAVGSFTGHTELEHSMVMLLRDLLVRHPECAAQNSMQKlIDQYPAALGVVQKALDLLLGIESqsdGKSVLSKVEKLARMTDDFSLP
 1180- 1287 (175.06/99.61)	QLKLQVLFHADsgSEDRTNIV.DAMFKTAVSDCRAHRLHWIDLVALMSPDAVRQIRERAEKAFFS.IPLLEEPLGDIPDLPDKLGSLET...AKMYLTIIEELASSIPDSGAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.18|      39|      71|     547|     585|       8
---------------------------------------------------------------------------
  547-  585 (66.30/38.30)	HIVRLLDSIRFSHDL..PSIFDYLNAF.DDKAVLVFKLLEWL
  616-  657 (57.87/32.55)	HILAFLSSGQNNQKLnvDQIYHVVSELvRSQTFSVGRYLQWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.92|      11|     473|     237|     247|      13
---------------------------------------------------------------------------
  237-  247 (20.33/12.78)	LYAQLKNRTGL
  699-  709 (19.59/12.04)	LRSTLLNRTGL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33785 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KPADFAPWTGNHPEDVLSEQTTKQGYYDRTQVSQNESNTARPALY
2) MIPHSSAGGQPWGHPLRTFNGGLGRVDNAQMLGQYDQPNRSASLPQPPIRQPAVVDLTAGGPESQDREPPPKRPRLEVPSRSNTSDTGLAVGETKNNPGSVISRPAAS
3) QALVSEIPSNENRGDGAALKPPSPPPLPAQPWMNNFVPEPEGSATVKSRESSPVGAVQTTP
194
1
118
238
108
178










Molecular Recognition Features






MoRF SequenceStartStop




NANANA