<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33783

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLIMEDGIDVDDLFGEPNSLELGLPTASPIKGLAQCLDEMRLSGCCQKIAWSRMGCIASISPDGIRVIIRYLQCRPSDGKWVLGEESSLAPVLEAHNGTQLAHLSWNETGSELAVVDCSGRVSIYSISIALNSITGLRQASFDSGDDGSQVVGMMWLNSQRYVHAFHQAAKVNGRWAYSPFRRRPVGPFHPANKGALICVTRAGQIKLIYQNPDSKWAELPAELKNTGYSDRLLTHASMTATQVHISWNPPQWEPAQGKLPGQFPIPTFRLIHCKVDMPNNILNVNRGPDHHDQSLPFLNSVYSLTRLEIMPGQFDSLAGSTANPWILAVLSKPLHAMHDYPDQQGPPSVIVRWHLESAPQILHPKFDEVTSKKSNAQAKPKMELRRLENVYCDKYIVSVDLVEHGTVLAVSHDDSSITCYDTRTMAVLNGLDDSSAVTCLAQAGFQYPLETSGLHIAFSPNACVAVTLDSDGHMQLRAMEHSFGSTEGLYDENNLSAAIAALTLAFSRGCGVDYNTDDILMVALGQLSLEAQTTFISEVYRALPVNCNFTAEQDKLMSHPYIPRCLSLQAGLGFKGRLKRRNLSSAVPWASLQLRHASVLFAYFFQYNKGGQTESHDPDVLRMVLGNTKWTLDFSHFLLSEIFDMADEFEDVFDDSEAFTQKLKNSSSLPLLILLSSMSRAFLRFICRGLRGVHAGFASANPASLLGDSRIYYTEICQTLESSPVRIDVYEKFLAGVDSAVKHAYQGAGFGDAERPGPEKELLVNARIPPVLTTAVATLLRQTVPALKSEINRMAIYLGDYSWLGFGNDRRTALYRRHREVDILKKCPLRPPLPLGNDGRVAPVKKRRCARCCEVSGDTNLPRSLLSFKMIAKLGLLRSCLCGGMWVLETDTGVLGIGTASANGNGNRIT
Length912
PositionTail
OrganismPenicillium roqueforti (strain FM164)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.08
Grand average of hydropathy-0.133
Instability index41.92
Isoelectric point6.61
Molecular weight100446.71
Publications
PubMed=24407037

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33783
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.26|      22|      35|     204|     237|       1
---------------------------------------------------------------------------
  204-  229 (28.39/45.68)	AGQIKlIYQNPdSKWAelPAELKNTG
  242-  263 (45.87/24.42)	ATQVH.ISWNP.PQWE..PAQGKLPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.73|      16|      26|     806|     821|       2
---------------------------------------------------------------------------
  806-  821 (30.45/18.17)	LGFGNDRRTALYRRHR
  835-  850 (29.28/17.21)	LPLGNDGRVAPVKKRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.98|      31|      49|     293|     325|       3
---------------------------------------------------------------------------
  307-  355 (38.09/24.95)	TRLEIMPGQFDSLAGSTANpwilavlskplhamHDypdqQGPPSVIVRW
  359-  393 (44.89/23.42)	SAPQILHPKFDEVTSKKSN..........aqakPK....MELRRLENVY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.95|      22|      35|     453|     474|       4
---------------------------------------------------------------------------
  453-  474 (39.81/25.14)	TSGLHIAFSPNACV.AVTLD.SDG
  488-  511 (28.15/15.78)	TEGLYDENNLSAAIaALTLAfSRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.19|      12|      27|     681|     692|      11
---------------------------------------------------------------------------
  681-  692 (22.44/16.75)	SRAFLRFICRGL
  711-  722 (22.75/17.10)	SRIYYTEICQTL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33783 with Med16 domain of Kingdom Fungi
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