<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33782

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMTMLSDRAIPEQWRTFLHQCLANRIDIDEFTDLSGLMFARAPVKENELLDLLLEARASSSVTWDPLLPLYVDGLCKIGRVRSSSALTSLLKHSSVMDALGTGDGDGEEGQGHGSPSKAKKHKPSTLMTDIKVIQDVMVFISTGSIPKTVIEAADIYSATVDWILAVVAWHNHSSDSEHATGGLMGSPDAVSLFESLGILLAALSGTGKGLEVLSSDYNQELKAKLGQALSSYLPLCIDVSLPLRHRLEGLQKVFHLYPGQPSKALGGPAIDGVNVNALQFESSVMDGPVINTRAGLYVYINSMVVGRPLVDDTILINYLTNRYQGHNDVLIEEIITAAFDVLSNGVYRNESGRTMLLFRSFLVNKLPAFFAAISAASMVPISMEMCISHALSRLDPNAFPSFSQMFSMQGSSVLSDARQEFLFACASHKLIRESSIEQLLGENPMQTLPGGGPYVKDDLVSQINNNHERAEQLIGEIESMEGNAGAIVGAVVDVMQNLCHQKETMTLKNICNSLSRRPQTLDVMLLFRTTKQVLQPLCAVLDSWKWDEDQGENQPVYDEFGSILLLVLAFKYRYDLSPTDMGISNNDSFLLKLLDRGACSQKLSDLSEKQNKDLGAWIGALFIAEGISEETMSSCSPHEFYMLVTTLFDQSLGACESGKLDFDTLKGGFEYLLEPFLLPSLVVALTWLGNHIWESETDPTIPIKTLHSLVKPNSISGEAQAIHQTVLNITGCPLEEQLKNVRTRNQSRTDIKPILDALEPYISFRRVGSCRRSELDTWTSHSAGGLIASIRTTLQALVLWSANPGISMAPHAYTHRQVLAGIRMLGATRVLGAIIDEVKQQSEAGNGHIALDIATTMVCAPMTESFAVDQNNYHPVDPSKEALPRCAILTLRDALSLQHENVPKISESDPLRAEVVVRLARRVNMLMAPPSQVSNIDVSNIIQNMHLGVEGHEDRMDLEPSAAGVSGDTVNEDDPDNINQMLDKAAADAAAAGMDGGGIGVGQDMGLDHGAGMDAIDDVLNAADMAVGNPEFLDLDMEDMF
Length1041
PositionTail
OrganismPenicillium roqueforti (strain FM164)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.06
Grand average of hydropathy-0.042
Instability index42.07
Isoelectric point4.83
Molecular weight113322.84
Publications
PubMed=24407037

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33782
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     606.03|     266|     523|     169|     495|       1
---------------------------------------------------------------------------
   75-  270 (180.18/182.51)	.......................................................................................................................................CKIGRVRSSSALTSLLKHSSvMDALGTGDGDGEEgqGHGSPSKAKKHKPSTLMTDIKVIQDvmvfiSTGSIPKTVIEAA.....................................................................................diysatvdwilavvawhnhssdseHATGGLMGSP....DAVSLF.ESLGILLAALSGTGK....GLEVLSS.........DYNQELKAKLGQ.ALSSYLPLcidVSLPLRHRLEGLQKVFHlyPGQPSK.ALGGPAI
  305-  495 (238.76/172.06)	VGRPLVddTILINYLTNRYQGHNDVLIEE.....IITAAF....DV..LSNGVYRNESGRTMLLFRSFLVNKLpaffAAISAASMVPISM...EMCISHALSrldPNAFPSFS.QMFSMQGSSVLSDArqefLFACASHKLIRESSIEQLLGENP.MQTLPGGGPYVKD..DLVSQINNNHERAEQLIGEIESMEG.....NAGAIVGAVVDVM..............................................................................................................................................................................................................................
  533-  671 (134.08/69.12)	VLQPLC..AVLDSWKWDEDQGENQPVYDEfgsilLLVLAFkyryDLspTDMGISNNDSFLLKLLDRGACSQKL....SDLSEKQNKDLGAwigALFIAEGIS...EETMSSCSpHEFYMLVTTLFDQS....LGACESGKL.............D.FDTLKGGFEY..............................................................................................................................................................................................................................................................................
  781-  888 (53.01/ 9.27)	......................................................................................................................................................................................................................llepfllpslvvaltwlgnhiwesetdptipiktlhslvkpnsisgeaqaihqtvlnitgcpleeqlknvrtrnqsrtdikpildalepyisfrrvgscrrseldtwtsHSAGGLIASIrttlQALVLWsANPGISMAPHAYTHRqvlaGIRMLGAtrvlgaiidEVKQQSEAGNGHiALDIATTM...VCAPMTESFAVDQNNYH..PVDPSKeALPRCAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.29|      22|      25|     982|    1003|       2
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  954-  974 (26.93/13.19)	.DRMDL.EPSAAGVSGDTVNEDD
  982- 1003 (35.46/19.78)	LDKAAA.DAAAAGMDGGGIGVGQ
 1007- 1029 (28.89/14.71)	LDHGAGmDAIDDVLNAADMAVGN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33782 with Med5 domain of Kingdom Fungi
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