<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33778
Description |
Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MSNLTQEQIKVLEQSRQRLVQLTRSLGSLIASLNQSDPLPPWTSLQSQASIISNNLISVSDQLSDQRDLLSNLVAYPGPEYPGRTQANTLEQLLRTKLDPRVEDWVARGRAAGTESTAGPSNFSSDSDAAHKPLSDAQLAELWEWAPLEANQEARRRNWGGNFTLEEREAGIENVVTGLRRQLQDDDGEEESEDEDGDGDGEEMDVVGVHRKPGAAEFEFNIATHHPHPVQPFVPLDLILRYMTTGRMP |
Length | 249 |
Position | Head |
Organism | Penicillium roqueforti (strain FM164) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.689 |
Instability index | 56.70 |
Isoelectric point | 4.57 |
Molecular weight | 27677.13 |
Publications | PubMed=24407037
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP33778
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 34.63| 12| 15| 45| 57| 1
---------------------------------------------------------------------------
45- 57 (14.95/17.12) LQSQASIISnNLI
63- 74 (19.68/15.29) LSDQRDLLS.NLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 41.92| 11| 15| 203| 213| 2
---------------------------------------------------------------------------
203- 213 (19.86/13.32) EMDVVGVHRKP
219- 229 (22.06/15.44) EFNIATHHPHP
---------------------------------------------------------------------------
|