<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33767

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTFQLSDLNPLFKAPGFLPGWQHPRSLGKNEAKQYTETNFYKFAQIRRVFYFVLQLKDHQQNEKSSTPSSSLGPPETSGESTNGSPTPQLNIYDYESLIRNQLAENYGGKGVLVIASGKDVWVFLMDVAEIEDPAASAQLQSALESLISDGRLPLNMHSVGSFTASEFAQKPNFSMYMNFFKAVRKSIFAKVSASGANAKGYMLPFATQLLIHNISPDSSDDFSVLKMNPSLSLKGELIVNMSMSNFPRFRRLSDLCPGDPVIATDDKVVYLCPSGVRCYFAVNGNCKDSLTEEAPSHLDKHIQLLKEHCDIILPQIPRKKAWVKLVPNLKHLNSLTPMISNFLEKDLARYGSSKYIVWPTCLCFIQTSVDTGQDSAQPNSKFEDPFDVVNDFIDADLEYDAKKEEEGFPVLNPPIADLEMHDFEEDVRMADDSKLWSEDRLEQKSDQESISHDEVSTPSPKGEDWDELFGDMEDEDDPMTNQLPNAAASSPSFSVQLGEEGLGSDMEESRSFEPVSTSLYEDPGAPAPLPLQIFASPSHDYQENRTISEKPESRSVTPNELKKSVFAPLNFNPVIQKSIDSKYSNGGKYFFGSSKTGSDDIEIDDPTTPSFKKFAQSRFGDITPSLQENDDSDLVSDSEYESSDSDSTSDNDVAEEMEVTPESNAGMVGLGINHGSLLSSQEPAISALSAGWTSSQNVNQSPIPGGPVENQNWLPFLLRTIPMYTIPACFMKNNPSISAGLLGSVLPIIQNLLVFGWANYLEDDTELASFDPCFQELMASRYLSSDIDNVMRTSFPGVAPLKLYELLGSSKSQQVKYFDYLTGEYKDSIEYTDQYIPQEFDDPNFATTSPLFNMNTAPESANFAQQASDTQSMLDSVSQSNLFHFPQSMINLKRMDQPLKVSLSGLKFWNLLNLQPLHGKADFRMVIVAPHINGFFADQCKDFFNSVVINYSSCKLGTVHPVEIVKKDDDECLLLSDGVLTIDTEDVNNEAQYWDSVRATLSLLAKSIQLSYLENERNADAQTADETQRLPILLFFADPFGSISSIVEAAKSVSEFADTVSMAVDSQSISDKNALDKQKKKKKSNASTPKTPVIPIVRLPIKVFQKIFPIDFCYSRDGGFSMCTNSILTKMSLSLYNICPSSDHSRDFMRTFTTISKDLPKKIDFKLTRMAIASSLISEDLFIHVAYERSIDKNWCVASWTDQYGSIRNLQSWHVPYESSKNGKGGSSAPFESVSNKMWNITMNYINNHTGKCYVILTRLNNVIPDDELIEWKRLSQKYKNMSLVVLTVDTSSSFLVKVGNANGYCGDPESSDAGFNAGFTGGKLNTNTVGSTSSNTGVTPFKIESPEVYGSMTTPSDFNMLSPSGGNTGKPPGTPGNSETSSIQDVTKEAFGLILNSPLPLSNQPTRIPIKTGYLYNVFPLNSERKDKSSLEVNLLSCPHFSNGPELVKTILFQYRNLSNLSDAWAMSKPHCKFNSMIPWHIMAVKKTLSGIVHIRVQ
Length1500
PositionKinase
OrganismKuraishia capsulata CBS 1993
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetales incertae sedis> Kuraishia.
Aromaticity0.09
Grand average of hydropathy-0.370
Instability index44.42
Isoelectric point4.88
Molecular weight166438.17
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP33767
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     207.00|      57|     125|     463|     522|       1
---------------------------------------------------------------------------
  463-  515 (80.67/45.78)	.....................GEDWdeLFGDME...DE...DDPMTNQLPNAAASSPSFSVQLGEEGLGSDMEESRSFEP
  516-  559 (67.01/32.66)	VSTSLY..................................eDPGAPAPLPLQIFASPSHDYQ..ENRTISEKPESRSVTP
  566-  635 (59.32/29.37)	VFAPLNfnpviqksidskysnGGKY..FFGSSKtgsDDieiDDPTTPSFKKFAQS......RFGD..ITPSLQENDDSDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     268.47|      85|     127|     664|     756|       2
---------------------------------------------------------------------------
  664-  756 (131.62/95.22)	SNAGMVGLGINH..GSLLSSQEPAISALSAGWTSSQNVNQSPIPGgpvENQNwlPFLLRTIPMY...TIP..ACFMKnNPSISAGLLGSVLPiiQNLLVF
  795-  886 (136.85/76.32)	SFPGVAPLKLYEllGSSKSQQVKYFDYLTGEYKDSIEYTDQYIPQ...EFDD..PNFATTSPLFnmnTAPesANFAQ.QASDTQSMLDSVSQ..SNLFHF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     401.18|     133|    1170|      91|     234|       4
---------------------------------------------------------------------------
   91-  234 (192.23/129.01)	NIYDYESLIR.NQLAENYGGKGVLVIASGKDVwVFLMDVAEIE....DPAASaqlQSALESLISDGRlpLNMHSVGSfTASEFAQKPnFSMYMN..FFKAVRKSIFAKVSASGAN.AKGYMLPFATQllIHNISPDSSDDFSVLkMNPSLSL
 1263- 1403 (208.96/108.34)	NVIPDDELIEwKRLSQKYKNMSLVVLTVDTSS.SFLVKVGNANgycgDPESS...DAGFNAGFTGGK..LNTNTVGS.TSSNTGVTP.FKIESPevYGSMTTPSDFNMLSPSGGNtGKPPGTPGNSE..TSSIQDVTKEAFGLI.LNSPLPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.54|      42|     309|    1099|    1152|       6
---------------------------------------------------------------------------
 1099- 1152 (62.17/65.36)	RLPIKV..FQKIFPIDfcYSRDGGFSMCTNsILTkmslslyniCPSSDHSRDFMRT
 1409- 1452 (69.37/41.66)	RIPIKTgyLYNVFPLN..SERKDKSSLEVN.LLS.........CPHFSNGPELVKT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.89|      17|     739|     423|     440|       7
---------------------------------------------------------------------------
  423-  440 (28.64/28.80)	DFEEdVRMADDSKLWSED
 1165- 1181 (30.25/23.63)	DFKL.TRMAIASSLISED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.79|      12|      19|     387|     399|      10
---------------------------------------------------------------------------
  387-  399 (18.47/16.63)	FDVVNDFIdADLE
  409-  420 (24.32/16.05)	FPVLNPPI.ADLE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33767 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DDSKLWSEDRLEQKSDQESISHDEVSTPSPKGEDWDELFGDMEDEDDPMTNQLPNAAASSPSFSVQLGEEGLGSDMEESRSFEPVSTSLYEDPGAPAPLPLQIFASPSHDYQENRTISEKPESRSVTPNELK
2) KKFAQSRFGDITPSLQENDDSDLVSDSEYESSDSDSTSDNDVAEEMEVTPESNA
3) MTTPSDFNMLSPSGGNTGKPPGTPGNSETSS
432
613
1354
563
666
1384










Molecular Recognition Features






MoRF SequenceStartStop




1) DWDELFGDMEDEDD
2) GGKYFFGS
465
587
478
594