<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33754
Description |
Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MSGIDTELVLPISEISEILQKRPGLVSIDGIKRLSNLYGFETFADAISGTVPPVERLSLSGKIVLIDIDFQAGVVSSVSISSAVAIAPLGSAQLDFLNPATSPNIEHILLENLRCERLDSFNRNLRTLAQLDRLSEPSPLDLFNFLHKLAYNLDCVAQYQLKVACEVSADKLKDLKDGYAGIGKIEINRDGKVGVFLKYWENTRRIRRWIEARDRSRYNPGQFHIHFKFMEKMELETRAEPNAESASEVAVASEDAPLVDEKFPDVWFENGKWLLTPGHVSRMATLVLELLPCVWVPEGLVAKWGTRCEFIASDNSNDYNGRILDPSPIDRMIGELNSGLYTQYSLNSRRLRISAIVGSRFVKLHKVMLSDVTQLQQIVDDLRSYCVLTNLLNRLLDEVTEYEEQAVPQIRLSDLAEGRVNGPTAAVGSSLVISNDNTGIKLLANGTSVTIRAGRLEGDSYLAVSEDLVLSRVL |
Length | 474 |
Position | Middle |
Organism | Kuraishia capsulata CBS 1993 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Saccharomycetales incertae sedis> Kuraishia.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.079 |
Instability index | 39.38 |
Isoelectric point | 5.21 |
Molecular weight | 52719.61 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP33754
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 55.58| 19| 21| 104| 122| 1
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104- 122 (32.90/22.26) NIEHI.LLENLRCER.LDSFN
124- 144 (22.67/12.99) NLRTLaQLDRLSEPSpLDLFN
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 73.62| 19| 25| 253| 271| 3
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253- 271 (37.16/22.30) SEDAPLVDEKFPDVWFENG
281- 299 (36.46/21.76) SRMATLVLELLPCVWVPEG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 46.90| 17| 23| 54| 70| 4
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54- 70 (26.95/16.39) VERLSLSGKIVL.....IDIDF
75- 96 (19.95/10.52) VSSVSISSAVAIaplgsAQLDF
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 42.54| 11| 28| 191| 201| 5
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191- 201 (20.71/13.03) GKVGVFLKYWE
221- 231 (21.83/14.04) GQFHIHFKFME
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