<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33752

Description Mediator of RNA polymerase II transcription subunit 24
SequenceMRGLKMVNLKQAILQAWKERWSDYRWAVNIKKNCPKGTTWDYPNLAEALLEQAMIGPSPNPLILSYLKYAISSQMVSYSSVLTAVSKFDDFSRELCVKSLLEIMDMFSNRLSCHGKAEECIALCRALLGAVVWLLQGCAWYCEKLKEPGGMPAGDASLRACQVRLENLLQRAKNRALMHIARLEEQASWSNMEQALIKLAENLGSVTNQTLKSKLEECVLLAKSVPQMLSVQCEPPVQTTFPSVHAFIMLEGTMNLTGEMQPLVEQLMMIKRIQRVPAPLFVLEIWKACFTGLIESPEGTEELKWTAFTFLKIPQVLLRLKKYPQGEKDFTEEVNMAFEYLLKLTPLLDKADQRCNCDCLSLLLQECHKLCLLSESNLAALTAKRADDREYAPKLKTAENANIQPNPGLILRAEPTVTNILKTVDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFIKLNEFPKHISGEGSKSASVRALLFDISFLMLCHVVQTYGSEVILSEPSQSGETPFFETWLQMCMPEEGKILNPDHPCFRPEPGKVESLVALLNTSSEMKLVQMKWHEICLSTPAAILEVLNAWENGVLSVEAVQKITDNIKGKVCSMAICAVAWLVAHVRMLGLDEREKPQTMIRQLMTPLYGENTLQFYNERVVIMSSILEHMCADVFQQTGQCLRSVVEPQEPMPYRALLPLRQPIRQALNSNFRMALDKGWVDSSTLHLLEDLLHIGGVFWFTNNLVKELLKETRREWAFRVVELLYSIFCLDLQQITLTLIGHIVPNLLTDPAHWHSLADPPGQALAKLSVWCALGSFSSHHKIHALARQRKRQREDIEDYSSLFPLDDTQPSKLMRLLSSNEDEPAVLSSPGDRTMSSSLSASQLHTVNMRDPLNRVLANLFLLISSILTSKTAGPHTQFVQSFIEECVECSEQGSRGSILQFMPFTMVSELVKLHALAKPKVVLSITDLTLPLGRRVAAKAIAAL
Length990
PositionTail
OrganismIctalurus punctatus (Channel catfish) (Silurus punctatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Siluriformes> Ictaluridae> Ictalurus.
Aromaticity0.07
Grand average of hydropathy-0.008
Instability index49.55
Isoelectric point6.91
Molecular weight110875.27
Publications
PubMed=23127152

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
enteric nervous system development	GO:0048484	IEA:Ensembl
interstitial cell of Cajal differentiation	GO:0061453	IEA:Ensembl
retinal cone cell development	GO:0046549	IEA:Ensembl
thymus development	GO:0048538	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33752
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     190.84|      62|     700|     191|     264|       3
---------------------------------------------------------------------------
  191-  264 (98.87/89.25)	NMEQALIKLAENLGSVTNQTLKSK............LEECVllaksvpqmlsvQC.EPPVQTTFPSVHAFIMLEGTMNLTGEMQPLV
  893-  967 (91.97/61.64)	NMRDPLNRVLANLFLLISSILTSKtagphtqfvqsfIEECV............ECsEQGSRGSILQFMPFTMVSELVKLHALAKPKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.54|      17|      29|     300|     317|       9
---------------------------------------------------------------------------
  300-  317 (24.94/21.78)	TEELKwTAFTF.LKIPQVL
  331-  348 (25.60/15.11)	TEEVN.MAFEYlLKLTPLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33752 with Med24 domain of Kingdom Metazoa
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