<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33750

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMMDVVYVCEWEKRSKSNHCPSVPLVCAWSCRNLIAFTTDLKNEDEDKDLSHMIHIIDSEHPWDVYSISSGHTEVISCLEWDQSGSRLLSADGDGQIKCWAMTEHLVNSWESTQCSSVEGEPIVALSWLHNGVKLALHVEKSGSTNFGEKFSRVKFSPSLTLFGGKPMEGWLAVTVSGLVSVSLLKPNGALLSASESLSRLRGRVALADIAFTGGGNIVVATTDGSSSSPVQFYKVCVSVVSEKCRIDTELLPSLFMRCTTDPVRRNKYPAVTHLKFLTRENSEQVLLCASSQTGSIVECWSLRKEGLPVNNIFQHRSPVVGEKQPMILKWRILSATNDLDRVSAVALPKLPISISNTDLKVASDTKFCPGLGLALAFHDGTIHILHRLSLQTMGVFPGTTGTSQRVGDEPTIKRQRTGGPTVHFKALQFSWTSLALVGVDNHGKLHMIRVSPSMGQMLDMNILLRHLLFLLEYCMVTGYDWWDVLLHVQHSMVHNLVEKLHEEYMRQNQALQQVLSTRIVAVKASLCKLSLATAARACDFYAKLLLIAISSTLKSLLRPHVLNTPDKSPGDRLAEICTKNTDTDIDKVMINLKTEEFVLDGPPLQSLQQLIQWVGDFVLYLLANLPNQGSTVRPGFGFLRDGPSLGMLREMMVMIRIWGLLKPGCLPIYTATSDNQDSMSLLFRLLTKLWLCSRDESHPQEPDETLLDECCLLPSQLLVPSMDWLPINDGVITKIQSKHHLRLQFGKPYTLPGLNPNSQIELFSRSPASQRMDNLRCLHMGICPTEDSKACTRCGCVTMLRSPNKTNAMKQWEQRWIKNCLCGGLWRKIPNSVA
Length834
PositionTail
OrganismIctalurus punctatus (Channel catfish) (Silurus punctatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Siluriformes> Ictaluridae> Ictalurus.
Aromaticity0.07
Grand average of hydropathy-0.068
Instability index47.94
Isoelectric point8.04
Molecular weight92926.68
Publications
PubMed=23127152

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33750
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     135.69|      41|     199|      78|     127|       1
---------------------------------------------------------------------------
   59-   93 (29.30/31.03)	...........EH....PWDVYSISSGHTE..VI....scleWdqsgsRLLSADGD
   94-  126 (50.33/39.21)	GQI.KCWAM.TEHL.VNSWESTQCSSVEGE..PIVaLS..................
  294-  338 (56.06/38.25)	GSIvECWSLrKEGLpVNNIFQHR.SPVVGEkqPMI.LK....W.....RILSATND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.31|      29|     190|     447|     475|       2
---------------------------------------------------------------------------
  447-  475 (52.89/33.31)	MIRVSPSMGQMLDMNILLRHLLFLLEYCM
  638-  666 (54.42/34.49)	FLRDGPSLGMLREMMVMIRIWGLLKPGCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.48|      29|     352|     375|     404|       5
---------------------------------------------------------------------------
  375-  404 (50.19/37.14)	LAFHDGTIHIL...HRLSLQtMG...VFPGTTGTSQ
  725-  759 (44.29/27.64)	LPINDGVITKIqskHHLRLQ.FGkpyTLPGLNPNSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     339.77|     113|     353|     136|     254|       6
---------------------------------------------------------------------------
  136-  254 (165.61/151.34)	LHVEKSGSTNFGEKFSRVKFSPSLTLfgGKPMEGWLAVTVSGLVSVSLLKPNGA........LLSASESL.SRLRGRVaLADIAFTGGGNIVVATTDgSSSSPVQfyKVCVSVVSEKCRIDTELLPSL
  486-  607 (174.17/132.60)	LHVQHSMVHNLVEKLHEEYMRQNQAL..QQVLSTRIVAVKASLCKLSLATAARAcdfyakllLIAISSTLkSLLRPHV.LNTPDKSPGDRLAEICTK.NTDTDID..KVMINLKTEEFVLDGPPLQSL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33750 with Med16 domain of Kingdom Metazoa
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