<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33738

Description Mediator complex subunit 12
SequenceXRRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGTAKNVNFNPAKISSNFSSIIAEKLRCNTLPDIGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHIDPFTEWTQIITKCLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEMAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVMSAQSTSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKLEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDSDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGSRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGNAASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELENGQHLDTSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVTNWKDDHYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELAERQSDSLEKVYQLLPLPKPTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEQGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVATKPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAVKTEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHLSYRQSSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPPYPGVLPTTMTGVMGLEPASYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTSYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMIGTMTSLGPQGVQAGIRSASILPEQQQPQQQQQQDTITSLSREGSRPRVPCASSALSVPLPLRFSPLPSLHGSLLSSRQQQQQQQQQQQQQQQQQQAHQQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPNTNIFGRY
Length2152
PositionKinase
OrganismOvis aries (Sheep)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Ruminantia> Pecora> Bovidae> Caprinae> Ovis.
Aromaticity0.06
Grand average of hydropathy-0.448
Instability index55.62
Isoelectric point6.61
Molecular weight238741.31
Publications
PubMed=20809919

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
chromatin binding	GO:0003682	IEA:Ensembl
protein C-terminus binding	GO:0008022	IEA:Ensembl
protein domain specific binding	GO:0019904	IEA:Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
axis elongation involved in somitogenesis	GO:0090245	IEA:Ensembl
canonical Wnt signaling pathway	GO:0060070	IEA:Ensembl
embryonic brain development	GO:1990403	IEA:Ensembl
embryonic neurocranium morphogenesis	GO:0048702	IEA:Ensembl
endoderm development	GO:0007492	IEA:Ensembl
heart development	GO:0007507	IEA:Ensembl
neural tube closure	GO:0001843	IEA:Ensembl
oligodendrocyte development	GO:0014003	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
post-anal tail morphogenesis	GO:0036342	IEA:Ensembl
Schwann cell development	GO:0014044	IEA:Ensembl
spinal cord development	GO:0021510	IEA:Ensembl
stem cell population maintenance	GO:0019827	IEA:Ensembl
Wnt signaling pathway, planar cell polarity pathway	GO:0060071	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33738
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     301.24|      43|      47|    2053|    2095|       1
---------------------------------------------------------------------------
 1831- 1885 (50.86/18.75)	Q..........KLPTR.PPYP.....G........V....LPttmtgvmglepasyktSVYRQQQPAVPQGQ......RLR..........QQLQAKIQ
 1886- 1925 (41.53/13.93)	S.........qGM.LGQSSVHQM..TP........S......................SSYGLQTSQGYTSY......VSH..........VGLQQHT.
 1933- 1988 (46.62/16.56)	...........PPSYSSQPYQST..HP........StnptLV................DPTRHLQQRPSGYV......HQQaptyghgltsTQRFSHQT
 1989- 2041 (38.59/12.41)	L.......qqtPM...IGTMTSLgpQGvqagirsaS....IL................PEQQQPQQQQQQDT......ITS..........LSREGSRP
 2042- 2094 (71.36/29.35)	RvpcassalsvPLPLRFSPLPSL..HG........S....LL................SSRQQQQQQQQQQQ......QQQ..........QQQQAHQQ
 2095- 2142 (52.28/19.48)	Q.....qqqaaP.P...QPQPQS..QP........Q....F..................QRQGLQQTQQQQQtaalvrQLQ..........QQLSNTQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     512.34|     166|     230|     203|     432|       2
---------------------------------------------------------------------------
  203-  399 (270.27/201.10)	GSTIGPLPHDVEM....AIRQWDYNEKLamfmfqDGMLDRHEFLTWVLECFEkIRPGEDELLKLLLPLLL..RYSGE...FVQSAYLSRRLAYFCTRRLalqldGVSSHSSHVMSAQSTS.TLPTTPAPQ...............PPTSSTPSTPFSD..LLMCPQHRPLVFGlscilqtillccpsalvwH..YSLT.DSR..IKTGSPLDHlPIAPSNLPM..PEGNSA
  437-  636 (242.06/171.84)	GFTIGRVLHTLEVldshSFERSDFSNSL......DSLCNRIFGLGPSKDGHE.ISSDDDAVVSLLCEWAVscKRSGRhraMVVAKLLEKRQAEIEAERC.....GESEAADEKGSIASGSlSAPSAPIFQdvllqfldtqapmltDPRSESERVEFFNlvLLFCELIRHDVFS..................HnmYTCTlISRgdLAFGAPGPR.PPSPFDDPAddPERKEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     251.02|      67|      76|    1627|    1697|       3
---------------------------------------------------------------------------
 1627- 1688 (88.88/53.18)	.................P..LPKPTRDVITCEPQGSL..IDTKGNKIAGFDSIFKKEQGLQVST..KQKISPWdlfEGLKPSAPL
 1689- 1761 (93.23/54.31)	SWGwFGTVRvdrrvatkP..LPLPPED..EEPPAPTL..LEPE..KKAPEPPKTDKPGAAPPSTeeRKKKST....KGKKRSQPA
 1766- 1823 (68.91/33.42)	DYG.MGPGR......sgPygVTVPP.DLLHHANPGSIshLSYRQSSI....GLYTQNQPLPAG...GPRVDPY............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     301.74|      76|     233|    1129|    1205|       4
---------------------------------------------------------------------------
 1129- 1205 (123.70/87.24)	LLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRiLLHLFKT.PQLNPCQSDG...NKP.............TVG.IR.SSCDRHLL.AASQNRIVDG
 1282- 1364 (86.34/54.97)	......RC..LKSLCEDSNDLQDPVLSSAQAQR.LMQLICY.PHRLLDNEDG...ENPqrqrikrilqnldQWT.MRqSSLELQLMiKQTPNNEMNS
 1365- 1441 (91.71/58.96)	LLENIAK.ATIEVFQQSA..ETGSSSGNAASN..MPSSSKTkPVLSSLERSGvwlVAP.............LIAkLP.TSVQGHVL.KAAGEELENG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.77|      31|      42|    1024|    1064|       6
---------------------------------------------------------------------------
 1024- 1060 (51.54/49.91)	TGLGKSLSENPANRYSFVCnalmhvCVGHHDSDRVND
 1069- 1099 (59.23/33.19)	TGYCKSLSAEWLGVLKALC......CSSNNGTCGFND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.53|      31|      42|     912|     943|      10
---------------------------------------------------------------------------
  912-  943 (52.92/43.07)	CIVAVLRH.YHACLILnQDQMAQVFEGLCGVVK
  957-  988 (53.61/38.16)	CILAYLYDlYTSCSHL.KSKFGELFSDFCSKVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.05|      14|     664|     109|     122|      11
---------------------------------------------------------------------------
  109-  122 (24.94/17.09)	GTKPLTQLAKKVPI
  773-  786 (25.11/17.28)	GTAETDQLAPIVPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.16|      21|      23|    1539|    1561|      13
---------------------------------------------------------------------------
 1539- 1561 (31.02/32.68)	QQTTewAVL.LLEIIISGTV..DMQS
 1564- 1587 (27.14/18.59)	ELFT..TVLdMLSVLINGTLaaDMSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.37|      28|      36|     125|     153|      16
---------------------------------------------------------------------------
  125-  153 (46.53/36.40)	KKEEVFGYlAKYTVPVMRAAW..LIKMTCAY
  163-  192 (48.84/33.35)	KKRHIDPF.TEWTQIITKCLWeqLQKMAEYY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33738 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKLEGTLGVLY
2) GAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSV
3) LEPASYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTS
4) RVATKPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAVKTEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHLSYRQSSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPPYPGVLPTTMTGVM
5) VLKAAGEELENGQHLDTSSRKERDRQKQKS
6) XRRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGTAKNVNF
7) YVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMIGTMTSLGPQGVQAGIRSASILPEQQQPQQQQQQDTITSLSREGSRPRVPCASSALSVPLPLRFSPLPSLHGSLLSSRQQQQQQQQQQQQQQQQQQAHQQQQQQAAPPQPQPQSQPQFQRQGLQQTQ
674
614
1853
1701
1430
1
1915
713
661
1909
1851
1459
51
2121










Molecular Recognition Features






MoRF SequenceStartStop




1) ALAKN
2) MAKYRSIRGE
89
122
93
131