<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33732

Description Mediator complex subunit 25
SequenceMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEGLRKHYLLPAIEEKEAGSQMKSSPVLPSQYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTETLVQKIGERGIYFSIVSPRKLPALRLLFEKAAPPAMLEPLQPPADVSQDPRHMVLVRGLVLPVGGGSAPGPLQPKQPVPLPPAAPAGATLSTAPQQPLPPVPQQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQATPGVGPPYTQTQATPATQLPPGPPGAPKPPPASQPSLVSTVAPGPGLAPPAQPGAPSMAGTVAPGGVSGPSPAQLGAPAPGGRRPVPHKTPAPGGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLDSLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGTQQAPPGLGPILEDQARPSQNLLQLRPPQPQPHSGQPHPRGAAPAPPGAPQGPPGAAPGPPPPGPLLRPQNPGANPQLRSLLLNPPPPPGSGAGGGSPPGPLSHFLCSPAPDWGAPPSSDLLGPPLLPPPPAQSWPAQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI
Length742
PositionUnknown
OrganismOvis aries (Sheep)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Ruminantia> Pecora> Bovidae> Caprinae> Ovis.
Aromaticity0.05
Grand average of hydropathy-0.275
Instability index61.22
Isoelectric point9.02
Molecular weight77644.48
Publications
PubMed=20809919

Function

Annotated function 
GO - Cellular Component
nucleoplasm	GO:0005654	IEA:Ensembl
transcription regulator complex	GO:0005667	IEA:Ensembl

GO - Biological Function
retinoid X receptor binding	GO:0046965	IEA:Ensembl

GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33732
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     213.53|      37|      40|     630|     666|       2
---------------------------------------------------------------------------
  247-  280 (41.50/ 6.01)	VpLPPAAP...AGATLSTAPQQP.lPPVPQQ....YQVP.GNL
  389-  420 (46.51/ 7.66)	L.GAP.AP..GG....RRPVPHK..TPAPGGVLEWQEKP.KPA
  630-  666 (72.94/16.36)	L.LRPQNP..GANPQLRSLLLNP..PPPPGSGAGGGSPP.GPL
  670-  709 (52.58/ 9.66)	L.CSP.APdwGAPPS.SDLLGPPllPPPPAQSWPAQLPPrAPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.36|      14|      54|     560|     574|       4
---------------------------------------------------------------------------
  325-  338 (27.31/ 7.18)	TQATPATQLPPGP.P
  560-  574 (24.04/ 8.92)	QRGMGTQQAPPGLgP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.67|      25|      31|     187|     211|       5
---------------------------------------------------------------------------
  187-  211 (43.47/14.92)	PRKLPALR...LLFEKAAPPAMLEPLQP
  219-  246 (44.19/15.32)	PRHMVLVRglvLPVGGGSAPGPLQPKQP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33732 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSAPGPLQPKQPVPLPPAAPAGATLSTAPQQPLPPVPQQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQATPGVGPPYTQTQATPATQLPPGPPGAPKPPPASQPSLVSTVAPGPGLAPPAQPGAPSMAGTVAPGGVSGPSPAQLGAPAPGGRRPVPHKTPAPGGVLEWQEKPKPASVDANT
2) TNHKQVQQQKLEQQRGMGTQQAPPGLGPILEDQARPSQNLLQLRPPQPQPHSGQPHPRGAAPAPPGAPQGPPGAAPGPPPPGPLLRPQNPGANPQLRSLLLNPPPPPGSGAGGGSPPGPLSHFLCSPAPDWGAPPSSDLLGPPLLPPPPAQSWPAQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMD
234
547
426
740










Molecular Recognition Features






MoRF SequenceStartStop




NANANA