<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33721

Description Mediator of RNA polymerase II transcription subunit 16
SequenceGTMDLAYICEWEKWPKSTHCPSGPLACTWSCRNLIAFTTDLRSDDQDLTRMIHILDTEHPWDVHSIRSEHSEAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESPVGSVVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQLYKVCVSVVNEKCRIDTELLPSLFMRCTTDLSRRDRLPAITHLKFLARDMSEQVLLCASSQTSSVVECWSLRKEGLPVNNIFQQLSPAVGDKQPTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAIFYSSAAPRPVDEPALKRPRTTGPTVHFKAMQLSWTSLALVGIDNHGRLSMLRISPSMGHSLDVGLALRHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVEKLHEEYTRQKAELQQVLSTRILAMKASLCKLSPCTVTRVCDYHAKLFLIAISSTLKSLLRPHVLNTPDKSPGDRLTEICAKITDVDIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQGSPLRPGHSFLRDGTSLGMLRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPTSEPDEALVDECCLLPSQLLIPSLDWLPVSDGLVSRLQPKQPLRLHFGKAPALPGGSSSLQLDGLIRVPGQPKMDHLRRLHLGAYPTEACKACTRCGCVTMLKSPNKTTAVKQWEQRWIKNCLCGGLWWRMPLSYP
Length831
PositionTail
OrganismOvis aries (Sheep)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Ruminantia> Pecora> Bovidae> Caprinae> Ovis.
Aromaticity0.06
Grand average of hydropathy0.017
Instability index49.53
Isoelectric point7.92
Molecular weight92020.91
Publications
PubMed=20809919

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
catalytic activity	GO:0003824	IEA:InterPro
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33721
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     192.18|      59|     195|      67|     126|       2
---------------------------------------------------------------------------
   67-  126 (103.54/62.79)	RSEHSEAITCLEW...DQSGSRLL..SADADGQIKCWSMADH...LANSWESPVGSVVEGDPIVaLSW
  263-  329 (88.64/49.55)	RRDRLPAITHLKFlarDMSEQVLLcaSSQTSSVVECWSLRKEglpVNNIFQQLSPAVGDKQPTI.LKW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     336.63|     105|     350|     368|     483|       3
---------------------------------------------------------------------------
  368-  483 (160.45/121.94)	PGLGLaLAFHDGsvhIVHRL.SLQTMAIFYSSAAPRPVDEPALKRP...RTTG.PTV.HFKAMQL.SWTSLALVGIDNHGRLSMLRiSPSmgHSLDVGLALRHllfLLEYCMVTGYdWWDILL
  717-  828 (176.19/101.33)	PSLDW.LPVSDG...LVSRLqPKQPLRLHFGKAPALPGGSSSLQLDgliRVPGqPKMdHLRRLHLgAYPTEACKACTRCGCVTMLK.SPN..KTTAVKQWEQR...WIKNCLCGGL.WWRMPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.16|      27|     628|      30|      61|       6
---------------------------------------------------------------------------
   30-   61 (37.40/45.19)	SCrnLIAFTTdlRSDDQDLTRMIHILDTEHpW
  661-  687 (49.75/35.14)	SC..LPVYTA..TSDTQDSMSLLFRLLTKL.W
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33721 with Med16 domain of Kingdom Metazoa
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