<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33714

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEEMKGEEELGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVASTGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAVMGESGGTQSAVSHLGSQDGGMLTMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPANNPATWDFVDPTQRVSCSCSRHKLLKRCTVGPSRPPTISQPGFSAGPSSSSSLPPPASSKHKTTERQDKGDKLQKRPLIPFHHRPSVAEELCMEQDPPGQKLGLAGIDSSLEVASSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQEAESLDPPSVPVNPALYGNGLELQQLSALDDRTVLVGQRLPLTAEVSETALYCGIRPSNPESSDKWWHSYHLPSVDDAEFRPPELQGERCDAKTEVTSESTALQRLLAQPNKRFKVWQDKQPQMQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPEGKNAMSLFSSTKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPTVGTEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTQLTEFKMEVEDGLGSPKPEEIKDFSYVHKVPTFQPFVGSSMFAPLKMLPSQCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQTTFLPQMEGARKPQEPPISLLLLLQNQHTQPFASLSFLDYISSNSRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRTLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGRTVAQKLTEELVSEWFSQPWGSEESDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLMPPKYQTPPAAAQPQAPPGSSGPLASNPGSAAPSVGSAFNPTSNGSSLNPAASSSTSGSAGPPVSASASAPIINQISTTSSSGFSGSVGGQNPSTGASTAERTQGSLGCAGDTEPGQSSSQPSQDGQESVTERERIGIPTEPDSADSQAYPPAVVIYMVDPFTYTAEEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKEKQTEPGETLGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIALPNRSRRSKVSARKIGLQKLWEWCVGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKRLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2076
PositionMiddle
OrganismOvis aries (Sheep)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Ruminantia> Pecora> Bovidae> Caprinae> Ovis.
Aromaticity0.07
Grand average of hydropathy-0.410
Instability index59.80
Isoelectric point5.69
Molecular weight227389.56
Publications
PubMed=20809919

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33714
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     356.82|      94|     114|     733|     845|       1
---------------------------------------------------------------------------
  173-  227 (81.55/29.88)	VGQQGLGSVK.DPSNCGMPLT......................PPT...SPE.QAVMG..E.SGGTQS..AVS..........HLG........SQDGGMLTMHS.............................................
  265-  340 (72.41/24.56)	............................................PTLEEEPANNP.ATwdF.VDPTQR.VSCScsrhkllkrcTVG........PSRPPTIS.......qpgfSAGPSSSSS..L.PPPASSK.........HKTTERQD
  733-  808 (107.62/48.23)	...........................................PPSLEQHPAFSPVMN..Y.KDGISS.ETVT..........ALG........MMESPMVSMVSTqLT....EFKMEVEDGLGS.PKPEEIKdFS....YVHKVPTFQP
  810-  925 (95.24/61.56)	VGSSMFAPLKmLPSQCLLPLKipdaclfrpswaippkieqlpmPPA..........AT..FiRDGYNNvPSVG..........SLAdpdylntpQMNTPV.....T.LN....SAAPASNSGAGVlPSPATPR.FSvptpRTPRTPR.TP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      65.39|      13|      64|    1438|    1450|       3
---------------------------------------------------------------------------
 1438- 1450 (23.02/11.61)	NPAASSSTSGSAG
 1463- 1475 (20.46/ 9.27)	NQISTTSSSGFSG
 1503- 1515 (21.91/10.59)	EPGQSSSQPSQDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.55|      25|      28|     992|    1016|       4
---------------------------------------------------------------------------
  992- 1016 (51.64/28.91)	NFDSC.CICACN..MNIK.GADVGLYIPD
 1019- 1047 (36.91/18.76)	NEDQYrCTCGFSaiMNRKlGYNSGLFLED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.71|      17|      22|    1241|    1257|       5
---------------------------------------------------------------------------
 1253- 1274 (20.43/ 7.99)	GYDKDfltiSPFSLPFwE...RLLL
 1278- 1297 (23.27/10.29)	GGHRD....VAYIVVC.PeneALLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.19|      18|      22|    1866|    1883|       6
---------------------------------------------------------------------------
 1842- 1858 (21.38/11.10)	.TALNMQSS...QLNTPQDAS
 1866- 1883 (31.10/20.59)	PTSSTIQVA...PANYPNEDG
 1886- 1906 (26.70/16.29)	PNNDDMFVDlpfPDDMDNDIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.59|      34|     123|    1196|    1241|       7
---------------------------------------------------------------------------
 1199- 1241 (48.84/51.87)	LQDAIQkkRTGRTweNIQHVQGPLTWQQFHKmagrgTYGSEES
 1325- 1358 (62.75/30.63)	LRDGIM..RVGRT..VAQKLTEELVSEWFSQ.....PWGSEES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.27|      15|      63|     423|     442|      11
---------------------------------------------------------------------------
  425-  439 (28.30/12.67)	LSPQPRGQEAESLDP
  567-  581 (26.97/ 7.48)	LSQQPGDSLGEVNDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     264.46|      62|    1026|     504|     566|      15
---------------------------------------------------------------------------
  357-  422 (90.20/51.52)	PSVAEelcMEQDPPgqKLGLAGID.SSLEVAS.SRKY..DKQ.MAVPSRNTSKQMNLNPMDSPHSPISPLP
  440-  497 (65.83/37.42)	PSVP.......VNP..ALYGNGLElQQLSALDDRTVLvgQRLpLTAEVSETALYCGIRPS.NP.ESSDK..
  505-  566 (108.43/64.35)	PSVDD...AEFRPP..ELQGERCD.AKTEVTSESTAL..QRL.LAQPNKRFKVWQDKQPQMQPLHFLDPLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.93|      26|      28|    1934|    1961|      17
---------------------------------------------------------------------------
 1934- 1961 (37.05/27.20)	GsHFQhSRSQGERL...LSREAPEELKQQPL
 1964- 1992 (44.88/23.67)	G.YFV.STAKAENLpqwFWSSCPQAQNQCPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.26|      23|    1265|      32|      55|      18
---------------------------------------------------------------------------
   32-   55 (39.46/30.41)	AFTFFlHGESNVCTSVEIAQHQPI
 1299- 1321 (43.80/29.07)	AKTFF.RDLSAVYEMCRLGQHKPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.69|      27|      29|    1720|    1748|      20
---------------------------------------------------------------------------
 1720- 1748 (44.42/36.10)	C..IVNI.ALPNRSRRSKVSarKIGLQKLWEW
 1749- 1778 (42.27/27.45)	CvgIVQMtSLPWRVVIGRLG..RLGHGELKDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.86|      19|      24|    1563|    1582|      21
---------------------------------------------------------------------------
 1563- 1582 (31.05/30.43)	NFWLLSLMRCyTEMLDNLPE
 1586- 1604 (34.81/27.03)	NSFILQIVPC.QYMLQTMKD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33714 with Med13 domain of Kingdom Metazoa
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