<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33713

Description Mediator complex subunit 12 like
SequenceMVRATWLIKMTCAYYSAISEAKIKKRPATDPNLEWTQISTRYLREQLAKISDFYHLASSAGDGPVPVPPDVEQAMRQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLALLLSDSPSLLAAHSPHVIIGPNSSSIGAPSPGPSGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNDSKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLTGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPAGENTDEHYPKDHDMKMEEQTIMAHMGIDSGTTNIFDEVDKNDFKTDFVSEFPIFSPMPGESCESANPSLGRRMSVNGEKLLKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSNTETGVGDEGQKARKNKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSACSKVKQTIYNNVIPANSNLRWDPDFMMDFIENPSARSINYSVLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACLLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRRDGNAEDIWTASQNSKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNNSSNAGVGLFSPNGIGNTDTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDIITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPTPKPRSYYLEPLPLPPEEEEEEPTSPISQEPERKSAELSDQGKTATDEEKKTKGRKRKTKSSSRVDEYPQSSVYRVPPNYSPISSQVMHHPQSTLWGYNLMGQPQQPGFFLQNQSVTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTPQQQAGSVVLSPTYNSRTYPAAHSNPALMERLRQMQQPPSGYVQQQAPPYLHPLTGSQRLNHQSLQQSPLVGGGIDAVLTSAHPNLPSVPLSQDPMRPRQPQVRQQQRLLQMQQPQQPPQPQQPPQPQGSSQTQSQTLGLQTMQPQQPLVRPSISKPNMRISSFLFLLGFFKGRLHFLMSHKIVKN
Length2022
PositionKinase
OrganismOvis aries (Sheep)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Ruminantia> Pecora> Bovidae> Caprinae> Ovis.
Aromaticity0.07
Grand average of hydropathy-0.393
Instability index56.55
Isoelectric point6.99
Molecular weight226142.25
Publications
PubMed=20809919

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33713
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     156.78|      26|      27|    1929|    1954|       1
---------------------------------------------------------------------------
 1738- 1763 (23.99/ 6.39)	SNM...LQ...........rrsgammQ.P..P.SLHAITSQQQL
 1764- 1797 (24.36/ 6.61)	IQMkllQQQ.......QQQ...rllrQAQTRPfQQGQPGDQAAL
 1798- 1820 (32.66/11.46)	FA......A.......QAR.......PSPQLP.QYPGLQQAQTM
 1869- 1896 (33.05/11.69)	RQM...QQPpsgyvqqQAP............P.YLHPLTGSQRL
 1946- 1974 (42.73/17.35)	LQM...QQP.......QQP....pqpQQPPQP.QGSSQTQSQTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     625.35|     172|     180|    1070|    1247|       2
---------------------------------------------------------------------------
  903- 1055 (189.99/107.26)	......................GHQDAGRINDIANFSSELTACCTVLSSEWLG................VLKALCCS...SNHVWGFNDVLCTvDvSDLSFHDSLATFIAiliarqcfslEDVVQHV..ALPSLLaAACGDA..DAEPGARMTcRLLLHL....FRAPQ...ACLLPQATGKPFPGIRSSCDRHLLAAAHNSIEV
 1068- 1245 (278.98/175.84)	LGDAKIGNNSVSSLKNDDFTMRGLRRDGNAEDIWTASQNSKSCGKSISIETANLRE..YARY.......VLRTICQQEWVGEHCLKEPERLCT.D.KELILDPVLSNMQA..........QKLLQLI..CYPHGI.KECTEG..DNLQRQHIK.RILQNLeqWtLRQSWlelQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEV
 1246- 1383 (156.38/85.93)	FQQSADLNNNSSNAGVGLFSPNGI...GNTDTSSTRQNGIKTFLSSSERRGVWLVAplIARLptsvqgrVLKAAGEELEKGQH.LGSSSKKER.D.RQ..KQKSMSLLSQ..........QPFLSLVltCL.KGQ.DEQREGllTSLQNQ.VN.QILSN...W..........................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      70.35|      21|      23|    1661|    1681|       3
---------------------------------------------------------------------------
 1661- 1675 (21.76/ 9.22)	.............SSRVDEYPQ...SSVYRV
 1676- 1695 (29.20/15.40)	PPNYS......PiSSQVMHHPQ...STLW..
 1821- 1846 (19.38/ 7.25)	PQGYTmygtqmP....LQQTPQqqaGSV.VL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.99|      22|      24|    1422|    1445|       4
---------------------------------------------------------------------------
 1422- 1445 (33.79/32.93)	WTTdwALLLLQIITSGTVDMHTNN
 1448- 1469 (36.20/25.32)	FTT..VLDMLGVLINGTLASDLSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.17|      16|      27|     747|     763|       5
---------------------------------------------------------------------------
  747-  763 (22.97/18.65)	LLLKSSSLAGSYtTGLC
  777-  792 (29.21/18.79)	LILNPDQTAQVF.EGLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.88|      23|      26|    1599|    1621|       6
---------------------------------------------------------------------------
 1599- 1621 (42.93/27.59)	PT......PKPRSYYLEPLPLPPEEEEEE
 1622- 1650 (31.95/18.31)	PTspisqePERKSAELSDQGKTATDEEKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.29|      12|     180|     642|     705|       7
---------------------------------------------------------------------------
  615-  626 (22.36/ 8.60)	GVGKERDEARHQ
  647-  658 (21.93/74.51)	GVGDEGQKARKN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33713 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QPGFFLQNQSVTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAI
2) QQQRLLRQAQTRPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTPQQQAGSVVLSPTYNSRTYPAAHSNPALMERLRQMQQPPSGYVQQQAPPYLHPLTGSQRLNHQSLQQSPLVGGGIDAVLTSAHPNLPSVPLSQDPMRPRQPQVRQQQRLLQMQQPQQPPQPQQPPQPQGSSQTQSQTLGLQTMQPQQPLVRPSIS
3) RSYYLEPLPLPPEEEEEEPTSPISQEPERKSAELSDQGKTATDEEKKTKGRKRKTKSSSRVDEYPQSSVYRVPPNYSPISSQVMH
4) TASTRPRSPAGENTDEHYPKDHDMKMEEQTIMA
1705
1773
1604
478
1757
1991
1688
510










Molecular Recognition Features






MoRF SequenceStartStop




1) YLEPL
1607
1611