<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33712

Description Mediator complex subunit 12 like
SequencePFLQQDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRPATDPNLEHAEWTQISTRYLREQLAKISDFYHLASSAGDGPVPVPPDVEQAMRQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLALLLSDSPSLLAAHSPHVIIGPNSSSIGAPSPGPSGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNDSKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLTGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPAGENTDEHYPKDHDMKMEIFSPMPGESCESANPSLGRRMSVNGEKLLKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSNTETGVGDEGQKARKNKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVIPANSNLRWDPDFMMDFIENPSARSINYSVLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACLLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRRDGNAEDIWTASQNSKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNNSSNAGVGLFSPNGIGNTDTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDIITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPTPKPRSYYLEPLPLPPEEEEEEPTSPISQEPERKSAELSDQGKTATDEEKKTKGRKRKTKSSSRVDEYPQSSVYRVPPNYSPISSQVMHHPQSTLWGYNLMGQPQQPGFFLQNQSVTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTPQQQAGSVVLSPTYNSRTYPAAHSNPALMERLRQMQQPPSGYVQQQAPPYLHPLTGSQRLNHQSLQQSPLVGGGIDAVLTSAHPNLPSVPLSQDPMRPRQPQVRQQQRLLQMQQPQQPPQPQQPPQPQGSSQTQSQTLGLQTMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
Length2122
PositionKinase
OrganismOvis aries (Sheep)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Ruminantia> Pecora> Bovidae> Caprinae> Ovis.
Aromaticity0.07
Grand average of hydropathy-0.418
Instability index56.94
Isoelectric point7.79
Molecular weight236992.10
Publications
PubMed=20809919

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP33712
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     235.19|      27|      27|    2024|    2050|       1
---------------------------------------------------------------------------
 1817- 1841 (27.86/ 8.30)	PAGSFVP......TNTKQAL.SNMLQ.........R............RS...G..AM
 1842- 1864 (25.03/ 6.69)	MQPPSLHA.....ITSQQQL.IQMKL.L.......Q............Q.........
 1894- 1932 (28.21/ 8.50)	QARP.SPQ.....LPQYPGL.QQAQTmP.......QgytmygtqmplqQT...P..QQ
 1949- 1982 (31.06/10.11)	PAAHSNPA.....L..MERL.RQMQQ.PpsgyvqqQ............AP...PylHP
 2024- 2050 (57.14/24.92)	PMRPRQPQ.....VRQQQRL.LQMQQ.P.......Q............QP...P..QP
 2053- 2083 (34.73/12.20)	PPQPQGSS.....QTQSQTLgLQTMQ.P.......Q............QPlfpR..QG
 2084- 2115 (31.18/10.18)	LQQTQQQQqtaalVRQLQKQ.LSSNQ.P.......Q............QG...V..TP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     217.04|      69|     151|       1|      76|       2
---------------------------------------------------------------------------
    1-   76 (108.67/84.96)	PFLQQDELTAVNVKQgFNNQPAFTGD.EH..GSARN..IVINPSKIGAYFSSILAEKLKLNTFQDTgkkkpqVNAKDNY..WL
  155-  230 (108.37/67.70)	PNLEHAEWTQISTRY.LREQLAKISDfYHlaSSAGDgpVPVPPDVEQAMRQWEYNEKLAFHMFQEG......MLEKHEYltWI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.46|      17|      27|    1083|    1099|       3
---------------------------------------------------------------------------
 1083- 1099 (31.41/16.53)	LPSLLAA..ACGDADAE....PG
 1107- 1129 (22.05/ 9.51)	LLHLFRApqACLLPQATgkpfPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     158.11|      39|     151|    1161|    1199|       6
---------------------------------------------------------------------------
 1161- 1199 (63.68/47.06)	LGDAKIGNNSVSSLKN..DDFTMRGLRRDGNAEDIWTASQN
 1313- 1351 (51.10/36.04)	LKDP..GSGSVAEMNNllDNIAKATIEVFQQSADLNNNSSN
 1357- 1388 (43.33/29.23)	FSPNGIGNTDTSSTRQ..NG..IKTFLSSSERRGVW.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.55|      24|      27|    1447|    1470|       7
---------------------------------------------------------------------------
 1447- 1470 (40.27/28.41)	VLTCL...KGQDE..QREGLLTSLQNQVN
 1472- 1500 (33.28/21.93)	ILSNWreeRYQDDikARQMMHEALQLRLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.17|      16|      27|     839|     855|       8
---------------------------------------------------------------------------
  839-  855 (22.97/17.16)	LLLKSSSLAGSYtTGLC
  869-  884 (29.21/17.29)	LILNPDQTAQVF.EGLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.29|      12|     180|     734|     838|      10
---------------------------------------------------------------------------
  707-  718 (22.36/ 7.47)	GVGKERDEARHQ
  739-  750 (21.93/128.20)	GVGDEGQKARKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.89|      21|     608|     422|     467|      14
---------------------------------------------------------------------------
  422-  448 (33.25/63.64)	CQESTAGvtisrvLHTLEVLDRHCFDR
 1226- 1246 (42.64/17.33)	CQQEWVG......EHCLKEPERLCTDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     111.10|      23|      26|    1692|    1714|      15
---------------------------------------------------------------------------
 1692- 1707 (22.38/ 8.92)	......................PT......PKPRSYYLEPLPLP
 1708- 1736 (27.49/12.87)	PEEEEEE...............PTspisqePERKSAELSDQGKT
 1737- 1774 (24.24/10.36)	ATDEEKKtkgrkrktksssrvdEY......PQSSVYRVPPNYSP
 1776- 1798 (36.99/20.20)	SSQVMHH...............PQ......STLWGYNLMGQPQQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33712 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QPGFFLQNQSVTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAI
2) QQQRLLRQAQTRPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTPQQQAGSVVLSPTYNSRTYPAAHSNPALMERLRQMQQPPSGYVQQQAPPYLHPLTGSQRLNHQSLQQSPLVGGGIDAVLTSAHPNLPSVPLSQDPMRPRQPQVRQQQRLLQMQQPQQPPQPQQPPQPQGSSQTQSQTLGLQTMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
3) RSYYLEPLPLPPEEEEEEPTSPISQEPERKSAELSDQGKTATDEEKKTKGRKRKTKSSSRVDEYPQSSVYRVPPNYSPISSQVMH
1798
1866
1697
1850
2122
1781










Molecular Recognition Features






MoRF SequenceStartStop




1) YYLEPL
1699
1704