<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33697

Description Cyclin dependent kinase 19
SequenceMDYDFKTKLAAERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEDEPEEKADKNQQQQQQTGPQPQAQPQAQQQQAVPQQAPSQQSGAQTNGTAGAGGGGAGGGGLQHSQDQGPPNKKPRLGPSGASSGAGVMQSEYQHSSSRLGYQSNVQGSAQSQGTMGYSSSSQQSSQYPHQSHRY
Length496
PositionKinase
OrganismLepisosteus oculatus (Spotted gar)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Holostei> Semionotiformes> Lepisosteidae> Lepisosteus.
Aromaticity0.09
Grand average of hydropathy-0.705
Instability index53.44
Isoelectric point8.66
Molecular weight55998.70
Publications









Function






Annotated function


GO - Cellular Component
cytosol	GO:0005829	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
nucleus	GO:0005634	IBA:GO_Central

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IBA:GO_Central
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IBA:GO_Central

GO - Biological Process
protein phosphorylation	GO:0006468	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33697
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     132.53|      32|      40|     368|     399|       1
---------------------------------------------------------------------------
  368-  399 (56.92/27.32)	ADKNQQQQQQT....GPQPQAQPQAQQQQAVPQQAP
  405-  436 (50.57/23.49)	AQTNGTAGAGG....GGAGGGGLQHSQDQGPPNKKP
  447-  474 (25.03/ 8.10)	AGVMQSEYQHSssrlGYQSNVQGSAQSQ........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.27|      25|      40|     102|     129|       2
---------------------------------------------------------------------------
  102-  129 (44.55/38.53)	HDLWhiiKFHRASK.ANKKPM.QLP.RGMVK
  143-  170 (34.73/21.52)	HANW...VLHRDLKpANILVMgEGPeRGRVK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33697 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPYPKREFLTEDEPEEKADKNQQQQQQTGPQPQAQPQAQQQQAVPQQAPSQQSGAQTNGTAGAGGGGAGGGGLQHSQDQGPPNKKPRLGPSGASSGAGVMQSEYQHSSSRLGYQSNVQGSAQSQGTMGYSSSSQQSSQYPHQSHRY
351
496










Molecular Recognition Features






MoRF SequenceStartStop




1) DQGPPNKKPRLGPS
2) HSSSRLGYQSNVQGS
3) SQGTMGYSSSS
4) SSQYPHQSHRY
428
456
473
486
441
470
483
496