<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33696

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPSKISSNFSSIIAEKLRCNTFPDTGKRKPQVNQKDNFWLVTARSQSSINNWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWMIKMTCAYYAAITETKVKKRHVIDPCIEWTQIITKYLWEQLQKVAEFYRQSSSQGCVSPLPSTPVEVETAMKQWEYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLMLQYSGEFVQSAYLSRRLAYFCTRRLNLLLSDGTVGPGAGGHQTHSITAQPGNALPPTPTPQPAGGNQPQTPFTDFYICPQHRPLVFGLSCMLQSIVLCCPSALVWHYSLTDSRNKTGSPLDLLPIAPSNLPMPGGNTTFTQQVRAKVREIEEQVKERGQAVEFRWSFDKCQETTAGFTIGRVLHTLEVLDSHSFEKSDFSNSLDSLYNRIFGSGQSKDGHEMNPDDDAVVTLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEVVDEKGSVSSGSLSAATLPVFQDVLLQFLDTQAPMLTEPGNESERVEFSNLVLLFCELIRHDVFSHNIYMCTLISRGDLASDSHLPRPRSPSDEPSDESERKEQEAASSVKMEDAGLSESMEIDHNSSAIFDDVMFSPPMHCESKGSPSPEKPAPEQDGKSTTKDKTLDPAFPLVYELPRHIQYATHFPIPQEESASHECNQRLVVLYGVGKQRDEARHTIKKITKDILKVLNRKSTAETGGEEGQKRKRTKPEAFPTAEDIFSKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHIQFIFDLMEYSLNISGLIDFAIQLLNELSLVEAELLLKSSSLVGSYTTGLCLCIVAVLRRYHSCLILNPDQTAQVFDGLRIVVKHGVNPADCSSAERCILAYLYDLYTSCSHLKSKFGEIFSDFCSKVKNSIYCNIDPSDSNMLWDPVFMIETIANPSAHNFNHSMVGKILNDSPANRYSFVCNVLMDVCVDHRDPERVNDIGILCAELTAYCRSLSAEWLGVLKALCCSSNNGNCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLVRCVAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQRNPSPQDSSKSDKPAVGIRSSCDRHLLAASQNSIVVGAVFAVLKAVFMLGDAELKGSGFPHPAGLDDTPEDDLGSKKSGGRAVSIETASLDVYAKYVLKSICQQEWVGERCLKSLSEDSSALQDPVLVNIQAQRLLQLICYPHRQLDSEEGENPQRQRIKRILQNMDQWTMRQSSLELQLMIKQSTNNELNSLLENIAKATIEVFQKSAEMISSNPLGNGSAVSGPIQGPVTNSNNASKMKPVLSSSERSGVWLVAPLIAKLPTTVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVQQIVTNWREDQYQDDCKAKQMMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSESLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFEKEGLQVSTKQKISPWDVFEGLKHSAPLSWGWFGTVRVDRKVTKFEEQQRLLLYHTHLKPKPRSYYLEPLPLPPEEEEPPTPVAPEPEKKLAEAVKPEKSSAAVATDSSKKKSSKKKRNHSSSKTEDFASTQRGVPYTAGMPPEMLHGQQGHPFNRMVYGPQSMGMYPQNQPLPPGGPRLDTTYRPTRTLPMRPNRPAAYPNMMTGMPGGVGNLITALDQQAYRAYKPQPPIQGQILRQQLQAKLSQGMLGQQVRQMPPNPSYGTLQPTQVPPPQGYTSYGPHMGMQQHPSQTGGMVPPAYANQPFQGSHPAPNPAMVDSLRQMQQRPSGYIHQQAPGYVHAMQNTPRFAHQQASIIQGLSHMPGQGVHPGMRSNQMLDFLRQQQALRVGIHSLFGLSGHQACLLLHWRAGAHVTVMLLCLYQTPFDQVSAAQPPAQAQPQALGMQPLPPQQPMFPRQGMQQTQQQQQTAALVRQLQQQLSNTQPQQNTNSFY
Length2155
PositionKinase
OrganismLepisosteus oculatus (Spotted gar)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Holostei> Semionotiformes> Lepisosteidae> Lepisosteus.
Aromaticity0.07
Grand average of hydropathy-0.419
Instability index52.33
Isoelectric point6.96
Molecular weight240156.06
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coactivator activity	GO:0003713	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33696
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     181.70|      30|      30|    1909|    1938|       1
---------------------------------------------------------------------------
 1891- 1931 (48.91/21.55)	Q.PPIQG..qilrqqlqaklsQGMLG.........QQV....RQMPPNPSYGTLQPT
 1932- 1968 (43.48/18.26)	QVPPPQG..............YTSYGphmgmqqhpSQT....GGMVP.PAYAN.QPF
 1969- 1996 (37.04/14.36)	QGSHPAP.............nPAMV..........DSL....RQMQQRPS.GYIH.Q
 1997- 2037 (28.60/ 9.25)	QAP...GyvhamqntprfahqQASII.........QGL....SHMPGQGVHPGMRSN
 2110- 2148 (23.67/ 6.27)	.LPPQQP..........mfprQGM.....qqtqqqQQTaalvRQLQQQLS..NTQPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.16|      21|      30|    1315|    1344|       2
---------------------------------------------------------------------------
 1315- 1344 (29.43/38.66)	SEegenpqrqrIKRILQNMDQWTMR..QSSLE
 1355- 1377 (27.73/15.65)	NE.........LNSLLENIAKATIEvfQKSAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.24|      28|      35|    1804|    1838|       3
---------------------------------------------------------------------------
 1804- 1838 (51.31/38.88)	P..PEMLHGQQGHPF..NRMVYGPQSM.GMypqnqplPPG
 1840- 1872 (41.93/19.00)	PrlDTTYRPTRTLPMrpNRPAAYPNMMtGM.......PGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.65|      13|      35|     196|     208|       4
---------------------------------------------------------------------------
  196-  208 (25.11/17.88)	WEQLQKVAEFYRQ
  232-  244 (26.53/19.37)	WEYNEKLAMFMFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.36|      10|      54|     588|     597|       5
---------------------------------------------------------------------------
  588-  597 (19.34/13.70)	EPGNESERVE
  644-  653 (19.02/13.32)	EPSDESERKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     111.96|      42|      54|    1170|    1213|       6
---------------------------------------------------------------------------
 1170- 1192 (30.73/10.35)	.................................PSPQDSSKSDKPA..VGIRSSCDRH
 1194- 1249 (45.98/23.27)	LAASQNSIVVGAVFaVLKAVfmlgdaelkgsgfPHP..AGLDDTPEddLGSKKSGGRA
 1250- 1298 (35.25/10.86)	VSIETASLDVYAKY.VLKSI.cqqewvgerclkSLSEDSSALQDPV.lVNIQ......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     139.20|      36|      37|    1045|    1081|       7
---------------------------------------------------------------------------
 1045- 1081 (60.04/47.31)	CVDHRDPE.RVNDIGIL....C.AELT..A......YCRSLsAEWLGVLKA
 1083- 1120 (42.17/27.13)	CCSSNNGNcGFND..LL....CnVDVSdlS......FHDSL.ATFVAILIA
 1123- 1164 (36.99/22.76)	CLLLEDLV.RCVAIPSLlnaaC.SEQD..SepgarlTCRIL....LHLFK.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.69|      17|      24|    1457|    1473|       8
---------------------------------------------------------------------------
 1457- 1473 (27.74/16.65)	KERDRQKQKSMSLLSQQ
 1484- 1500 (26.95/15.94)	KGQDEQREGLLTSLYSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.51|      15|      37|    1394|    1416|       9
---------------------------------------------------------------------------
 1394- 1416 (20.78/25.69)	IQGPVtnsnnaskMKPV.........LSSSER
 1433- 1456 (18.72/ 7.32)	VQGHV........LKAAgeelekgqhLGSSSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.45|      13|      37|    1559|    1573|      10
---------------------------------------------------------------------------
 1559- 1573 (18.25/19.54)	ISSGTvdMQSNNELF
 1595- 1607 (23.19/15.92)	ISQGS..MEENKRAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.90|      16|      37|     703|     718|      11
---------------------------------------------------------------------------
  703-  718 (27.02/16.65)	PAPEQDGKSTTKDKTL
  739-  754 (28.88/18.42)	PIPQEESASHECNQRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.18|      13|      37|    1708|    1726|      12
---------------------------------------------------------------------------
 1708- 1724 (19.27/21.51)	EEQQRlllyHTHLKPKP
 1737- 1749 (24.91/ 8.54)	EEEEP....PTPVAPEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.51|      24|    1316|     320|     343|      13
---------------------------------------------------------------------------
  320-  343 (46.67/31.39)	HQTHS.ITAQPGNALPPTPTPQPAG
 1637- 1661 (38.84/24.56)	KQTRDvITCEPQGSLIDTKGNKIAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.49|      19|      37|     761|     779|      17
---------------------------------------------------------------------------
  761-  779 (30.36/21.29)	GKQRDEARHTIKKITKDIL
  795-  813 (32.13/23.01)	GQKRKRTKPEAFPTAEDIF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33696 with Med12 domain of Kingdom Metazoa
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