Description | Mediator of RNA polymerase II transcription subunit 6 |
Sequence | MASVDVRDNLLGISWVDSGWVPILNPGNVLDYFSERSNPFYDRTCNNEVVKMQRLTLDHLNQMVGVEYILLHAQEPILYIIRKQQRQSPSQVIPLADYYIIAGVVYQAPDLGSVIGSRVLSAVHGIQSAFDEAMSYCRYHPSKGYWWHFKDQDDKEKAKPKSKKKEEPSSLFQRQRVDTLLLDLRQKFPPAFYQPKPGEKPVPVEVKKEPEPPAEAAKQEEREATKTPAPAPPSKAPPEKRPRLQ |
Length | 245 |
Position | Head |
Organism | Lepisosteus oculatus (Spotted gar) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Holostei> Semionotiformes> Lepisosteidae> Lepisosteus. |
Aromaticity | 0.09 |
Grand average of hydropathy | -0.662 |
Instability index | 58.43 |
Isoelectric point | 8.67 |
Molecular weight | 27977.62 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 PIRNR:PIRNR023869 |
GO - Cellular Component | core mediator complex GO:0070847 IBA:GO_Central mediator complex GO:0016592 IBA:GO_Central |
GO - Biological Function | transcription coactivator activity GO:0003713 IBA:GO_Central |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central |
Binary Interactions |
Repeats | >MDP33692 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 50.79| 15| 17| 208| 222| 1 --------------------------------------------------------------------------- 208- 222 (26.61/11.42) KEPEP.PAEAAKQEER 226- 241 (24.18/ 9.78) KTPAPaPPSKAPPEKR --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 41.02| 11| 18| 79| 89| 2 --------------------------------------------------------------------------- 79- 89 (20.77/12.31) YIIRKQQRQSP 99- 109 (20.25/11.86) YIIAGVVYQAP --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) FYQPK 2) VPVEVKKEPEPPAEAAKQEEREATKTPAPAPPSKAPPEKRPRLQ | 192 202 | 196 245 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab