<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33689

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMAAVSGVVISGCSPARELGPGAPTVGPPTIGDRPRPEEGTEAEKQSRVGALLERLHAKHCASRPWQETSKVVRQAMEKRNVLNAGGHQLLLTCLETLQRALKVSSLPAMTDRLESIARQNGLGSHLSPSGTECYITSDMFYVEVQLDSGGQLVDVKVAHHGENPASCPELVQHLRERNFEEFSKHLKGLVNLYKLPGDNKLKTKMYLALQSLEMDLTKMMHMFRLATNANTVETILHGSVGLVTARSGGHLVTLQCYVSPYDVFEEETGALLNLTDSNVPRNLGVGVSVTIEGTSSVYKLPIAPLITGTHPVDNKGTPSFSSVTNSNCVDLPACFFLKLRRPLPFSLSFIHRMGNATGIPLFETAPPLAPLYELITQSQLQEEGGGALPPLAHNMRFYASLPGQQHCYFLNRDAPVQDGRCLQGALVTKVPFRHPAQVPALLDIIRHQAAYNTLIGSCVKRTVLKEDTPGLLQFEVCPLTDSSFSVSFQHPVNESLVCVVMEVLDSRQVSCKLYKGLSDALICTDDFITKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPAGSPGYGMGTGGGAAGGGGGAGASFPGPISTLFGMGLALKERHEGRGGHGDDFSKVTQNPILTSLLQITGNVGSSPTQAPPAAGHQPHHTPPPASSPASNTKNHPMLMNLLKDNPSQDFSSLYSSSPLERQNSSGSPRTDIMGGGSCGGGGGVSGGKTKKKRQRNPDKHHQHHQLEDDFHRELFSMDVDASQNPIFDVNLPGDGLDTPHSITPAPSQCGTPPTQQQQQQVAPPQPPPSGPSRMVRLSSSDSIGADINEILSDIPEQAGKMAAGGGGGHGPHHHGLGGGDDGGALGTPIRDSSSSGQGSAVFEADLFSAGSNENPFTDPVDLIADAATAATPNSDSSSNNFFPDTVDFNPELLAGPGFPQAYFEDSSPSADGDLDLVKGFGGGSQQHTPAGTPQNPTPHGRSTPDPSMKDPFEMSMVFGGSGGGGKPLLGGPLPAPDLADSHSGGGQSPLMMMGMGGGGGSDFKSDAKAKQQQLMRGGGKEGNGGGGGGGSGLGGASGGSSEGKQGKRSRTPSSDGKSKDKPPKRKKLDPEGKSPSHSSGGRPYTPPSGIGGSGGGSMGAGGGSKSPGSSGRSQTPPGGATPPIPKITIQIPKGTLTGGKTSSHGGYTSSSSAGGGGGGAAGGGGSKSHHSHSSSSSSSSGKMKGSKSDGSLGQGGGSKPGGGGGGCSGGGGGGGGGSQSKGSSQGMGGGKPGSSPITKHGLAGAGVVAGGGVGGGAKMKPQGGKPPASLINPNIKPNISPSHSRGVGAPDKLSSPMKLQQQQVPGTPPSSKAKSPMGSGGGGLGSGSKTSSGSGMGPQKQQMGGTSSSGSSSSSSSSSSSSSSSSSSSSSSSFSAGSQSQYGGGGGGGGGGGGNNNPNAKGKSPSRNKKPSLTAVIDKLKHGVGTGGXGPPSSKHGGEYMSKRDKGDKESKSKVSMSGVGSGDKKALDSKSGVVSSTGVAKIIISKPDGGSPSIKAKVTLQKPGEGSGEAMRSQLSGPKAYGSPLFSASTPKHDRCSPSHGRSPGYTPLNPDSESESGSSSVAEKSHQNSPSSDDDQALRPLQPPHEYMSSMPISSGEKHKKHKKEKKKQKERERERERDRDKEKKKSSSSCSTSSSHPLKADSWSRSPIAAPDPSLSLLGSDRPARPSPAYLRTEDDDLMDSALTGN
Length1734
PositionMiddle
OrganismLepisosteus oculatus (Spotted gar)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Holostei> Semionotiformes> Lepisosteidae> Lepisosteus.
Aromaticity0.04
Grand average of hydropathy-0.595
Instability index58.34
Isoelectric point9.04
Molecular weight177004.95
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364059

GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
retinoic acid receptor binding	GO:0042974	IBA:GO_Central
thyroid hormone receptor binding	GO:0046966	IBA:GO_Central
transcription coregulator activity	GO:0003712	IBA:GO_Central
vitamin D receptor binding	GO:0042809	IBA:GO_Central

GO - Biological Process
cellular response to thyroid hormone stimulus	GO:0097067	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33689
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|    1158.18|     169|     171|     949|    1117|       1
---------------------------------------------------------------------------
  633-  803 (188.12/35.36)	.T....QN.PILTSLLQ.ITGN.VGSSPTQA...PPAAGhQPHHTPPPA.SSPaSNTKNHPMLMNLLK........DNPSQ.........DFSSlySSSPLERQ....NSSGSPRTDIMGG....GSCGGG.GGV.......SGGKT...KKK............RQRNP.......DKHHQHHQLEDD....................fhrelfsmdvDASQNP.IFDVNL...PGDGlDTPHsiTPApsqcGTP......P......TQ.QQQ
  807-  986 (195.96/37.18)	AP....PQ.PPPSGPSR.M.VR.LSSSDSIGadiNEILS.D...IPEQA.GKM.AAGG.........G........GGHGP...................HHHG....L..GGGDDGGALGtpirDSSSSGQGSAvfeadlfSAGSN...ENPftdpvdliaDAATAATPNSDSSSNNFFPDTVDFNPEllagpG.......fpqayfE..........DSSPSA.DGDLDLVKGFGGG.SQQH..TPA....GTPQ....NP......TP.HGR
  987- 1164 (287.10/58.35)	ST....PD.PSMKDPFE.MSMV.FGGSGGGG...KPLLG.GPLPAPDLA.DSH.SGGGQSPLMMMGMG........GGGGS.........DFKS..DAKAKQQQ....LMRGGGKEGNGGG....GGGGSGLGGA.......SGGSS...EGK.........QGKRSRTPSSDGKSKDKPPKRKKLDPE.....G...kspshssggrP..........YTPPSGiGGSGGGSMGAGGG.SKSP..GSS....GRSQ............TP.PGG
 1165- 1330 (192.15/36.29)	AT....PPiPKI......TIQI.PKGTLTGG...KTSSH.GGYTS.....SSS.AGGGGG.....GAA........GGGGSkshhshsssSSSS..SGKMKGSKsdgsLGQGGGSKP.GGG....GGGCSGGGGG.......GGG......GS.........QSKGSSQGMGGGKPGSSPITKHGLAGA.....G............vV...............A.GG......GVGGG.AKMK..PQG....GKPPasliNPnikpniSPsHSR
 1351- 1469 (165.17/30.03)	GT....P..PSSKAKSP.M......GSGGGG...........LGSGSKT.SSG.SGMGPQKQQMGGTS........SSGSS.ssssssssSSSS..SSSSSSSS....SFSAGSQSQYGGG....GGGGGGGGGN.......NNPNA...KGK....................SPSRNKKP..................................................................SL....TAVI....DK......LK.HGV
 1470- 1625 (129.69/21.78)	GTggxgP..PSSKHGGEyMSKRdKGDKESKS...KVSMS.GVGSGDKKAlDSK.SGVVSST......GvakiiiskPDGGS.........P.SI..KAKVTLQ...........KPGEGSG....EAMRSQLSGP.......KAYGSplfSAS.........TPKHDRCSPSHGRSPGYTP....LNPD.....SesesgsssvaeksH..........QNSPSS.DDDQAL...........................................
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33689 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ARELGPGAPTVGPPTIGDRPRPEEGTEAEKQSRV
2) LLAGPGFPQAYFEDSSPSADGDLDLVKGFGGGSQQHTPAGTPQNPTPHGRSTPDPSMKDPFEMSMVFGGSGGGGKPLLGGPLPAPDLADSHSGGGQSPLMMMGMGGGGGSDFKSDAKAKQQQLMRGGGKEGNGGGGGGGSGLGGASGGSSEGKQGKRSRTPSSDGKSKDKPPKRKKLDPEGKSPSHSSGGRPYTPPSGIGGSGGGSMGAGGGSKSPGSSGRSQTPPGGATPPIPKITIQIPKGTLTGGKTSSHGGYTSSSSAGGGGGGAAGGGGSKSHHSHSSSSSSSSGKMKGSKSDGSLGQGGGSKPGGGGGGCSGGGGGGGGGSQSKGSSQGMGGGKPGSSPITKHGLAGAGVVAGGGVGGGAKMKPQGGKPPASLINPNIKPNISPSHSRGVGAPDKLSSPMKLQQQQVPGTPPSSKAKSPMGSGGGGLGSGSKTSSGSGMGPQKQQMGGTSSSGSSSSSSSSSSSSSSSSSSSSSSSFSAGSQSQYGGGGGGGGGGGGNNNPNAKGKSPSRNKKPSLTAVIDKLKHGVGTGGXGPPSSKHGGEYMSKRDKGDKESKSKVSMSGVGSGDKKALDSKSGVVSSTGVAKIIISKPDGGSPSIKAKVTLQKPGEGSGEAMRSQLSGPKAYGSPLFSASTPKHDRCSPSHGRSPGYTPLNPDSESESGSSSVAEKSHQNSPSSDDDQALRPLQPPHEYMSSMPISSGEKHKKHKKEKKKQKERERERERDRDKEKKKSSSSCSTSSSHPLKADSWSRSPIAAPDPSLSLLGSDRPARPSPAYLRTEDDDLMDSALTGN
3) SLLQITGNVGSSPTQAPPAAGHQPHHTPPPASSPASNTKNHPMLMNLLKDNPSQDFSSLYSSSPLERQNSSGSPRTDIMGGGSCGGGGGVSGGKTKKKRQRNPDKHHQHHQLEDDFHRELFSMDVDASQNPIFDVNLPGDGLDTPHSITPAPSQCGTPPTQQQQQQVAPPQPPPSGPSRMVRLSSSDSIGADINEILSDIPEQAGKMAAGGGGGHGPHHHGLGGGDDGGALGTPIRDSSSSGQGSAVFEADLFSAGSNENPFTDPVDLIADAATAATPNSDSSSNNFFPDTVDFNP
15
937
640
48
1734
935










Molecular Recognition Features






MoRF SequenceStartStop




NANANA