<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33687
Description |
Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MESEKRVPADKDSPAKSLITALHLKYVEKPWSETINLVCRCMEKRKKDSNVPSKQLLDCLERLHKALNATSFTDMVTRLEIIAKHKGLGSHLSPSEDVCYITSDIFYLEVLFQPAGEVADVKVAHHGEAPVSSEMLCNLLRLKNFEEFGKELEGLSSLFNTSGDSETNMKMFSALQFVEKDLLKMFQIPRPVSSGDPWLDNVLHGRIGNVTPRNNGYPMSIEYYISPYDLLEEKMKPESRSCGNKVFVTAEVTNTIQRLPSASVIADSPQMTNEGFPVHATLDDLVSMELSACLFLKFPRPVPILSCFIEEFHRLTGISVSEDLKQVPFYELLMKTKMNVTTWGSDSCCFLVTLPGHHRQGYVISQQWWLKPWEGALVHKIPFTHPGHVPSLLSLLRHQTAFSTLIASCVTGKRAQPGSSVDFHFEILPYTGTSFSLSFQHPVTGSMASLFVNVVDSNHISCKLFPPEVPDPSIDDWISKVMKRCMSIPVTMRAIFRKIASRETPTASETGAAPENTSEITATTSSSLPIAQENTQSANHCPGALVMFFLQNL |
Length | 553 |
Position | Middle |
Organism | Lepisosteus oculatus (Spotted gar) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi>
Actinopterygii> Neopterygii> Holostei> Semionotiformes> Lepisosteidae>
Lepisosteus.
|
Aromaticity | 0.08 |
Grand average of hydropathy | -0.138 |
Instability index | 51.80 |
Isoelectric point | 6.18 |
Molecular weight | 61677.24 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP33687
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 50.61| 16| 114| 6| 29| 2
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6- 22 (22.44/25.06) RvPADKDSPAKSLITAL
45- 60 (28.17/ 9.88) R.KKDSNVPSKQLLDCL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 139.71| 40| 114| 287| 348| 3
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308- 348 (67.46/31.13) FIEEFHRLTGISVSEDLkQVPFYELLMKTKMNVTTWGSDSC
423- 462 (72.25/34.43) FHFEILPYTGTSFSLSF.QHPVTGSMASLFVNVVDSNHISC
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