<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33685
Description |
Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MESEKRVPADKDSPAKSLITALHLKYVEKPWSETINLVCRCMEKRKKDSNVPSKQLLDCLERLHKALNATSFTDMVTRLEIIAKHKGLGSHLSPSEDVCYITSDIFYLEVLFQPAGEVADVKVAHHGEAPVSSEMLCNLLRLKNFEEFGKELEGLSSLFNTSGDSETNMKMFSALQFVEKDLLKMFQIPRPVSSGDPWLDNVLHGRIGNVTPRNNGIRYPMSIEYYISPYDLLEEKMKPESRSCGNKVFVTAEVTNTIQRLPSASVIADSPQMTNEGFPVHATLDDLVSMELSACLFLKFPRPVPILSCFIEEFHRLTAGISVSEDLKQVPFYELLMKTKMNVTTWGSDSCCFLVTLPGHHRQGYVISQQWWLKPWEGALVHKIPFTHPGHVPSLLSLLRHQTAFSTLIASCVTGNEQALHLSMLNELDFHFEILPYTGTSFSLSFQHPVTGSMASLFVNVVDSNHISCKLFPPEVPDPSIDDWISKVMKRCMSIPVTMRAIFRKIASRETPTASETGAAPENTSEITATTSSSLPIAQENTQSANHCPGALVMFFLQNL |
Length | 560 |
Position | Middle |
Organism | Lepisosteus oculatus (Spotted gar) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi>
Actinopterygii> Neopterygii> Holostei> Semionotiformes> Lepisosteidae>
Lepisosteus.
|
Aromaticity | 0.08 |
Grand average of hydropathy | -0.121 |
Instability index | 50.63 |
Isoelectric point | 6.00 |
Molecular weight | 62600.33 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | mediator complex GO:0016592 IBA:GO_Central
|
GO - Biological Function | retinoic acid receptor binding GO:0042974 IBA:GO_Central
thyroid hormone receptor binding GO:0046966 IBA:GO_Central
transcription coregulator activity GO:0003712 IBA:GO_Central
vitamin D receptor binding GO:0042809 IBA:GO_Central
|
GO - Biological Process | cellular response to thyroid hormone stimulus GO:0097067 IBA:GO_Central
regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central
|
Interaction
Repeat regions
Repeats |
>MDP33685
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 50.61| 16| 117| 6| 29| 2
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6- 22 (22.44/27.74) RvPADKDSPAKSLITAL
45- 60 (28.17/11.16) R.KKDSNVPSKQLLDCL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 132.87| 38| 41| 309| 347| 4
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309- 347 (62.71/40.93) CFIEEFH.RLTAGISVSEDLKQVPFYELLMKtKMNVTTWG
352- 390 (70.15/41.85) CFLVTLPgHHRQGYVISQQWWLKPWEGALVH.KIPFTHPG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 59.51| 18| 169| 279| 305| 5
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283- 304 (25.38/30.21) TLDDLVSMELSACLFLkfprPV
480- 497 (34.13/10.79) SIDDWISKVMKRCMSI....PV
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 117.16| 34| 36| 403| 436| 6
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403- 436 (57.81/32.20) TAFSTLIASCVTGNEQALHLSMLNELDFHFEILP
440- 473 (59.35/33.22) TSFSLSFQHPVTGSMASLFVNVVDSNHISCKLFP
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