<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33681

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYSFRGNGDCGPVISAPAQDDPILRSFTRCVQANLLCVWRRDVKPEAKELWIFWWGEEPNLADIIHHELEVAEEGLWESGLSYECRTLLFKAIHNLLERCLMDKDFVRIGKWFVKPYEPEEKNLNNSEHLSCAFTFFLHGESNVCTSVEIARHQPAYRINEDHIALAQTSSSPFQVILSPYGLNGTLTGQAYKMSDPAVRKLMEEWCYFYPMVLRKRESEREDAEPGYDNDSHVAVEVIVGGVRMVYPAAFVLVAQGDLPMFQAPTVSGSQGATRDPSNASVPLTPPTSPEQPCTDDTGFQTTVSSSPGQEGGICTTTPSPKHSGRKLSNQALHQAWKECYLNKTHHKRTLSGSMTPEEEVPNSVPTWDFIDQAQRAPCCCSRHKSQKQRQMSALGRPPANSQPGANPTPPAAPSLPPPAPSKHKVADKPEKTEKQPKRLAMTPFHHRLSLSQEACLEQDPASGQKLGLVALEPPLDVLPSCKFPKPLPATGKVPDSPVHSPVSPLPPTLSPHPRMQDPEVLEPPVGLPPCPEVPLGPRLPEPSESTLYVAPLSFSEAGGGWWKGYKLPSSDTPEFRPSDVHCERAELKPDAATEGAALKRLFTQSHKRFKISEERVRKQVRTLGLLEQPGIEGLGGPGESSDPYAFVDTEIEYIFTSSKRVKGVGQERDPCRKVKGEEMTSGNSNPVPDGKDAMSIFSTAPKSDDSRQDSAAAKANPSLTRETDLVVLISDLENIFDNSDEDELGTTSPTRQSTRAPAAGAEDRPLGKDGRTTVPYPPTVADLQRMFPTPPSLEQHPAFSPVMTYRDALSAEPPPGMAGAENHLGTLSTAQLSEFKMEVEEGLASPKPEDIKDFSYVFCVPPVQLQLGCSMFAPLRTLPSQCLPPLKVPETCYYRPSWALPPKMEQLPLPPHVPFTRDGYVNVPSVGSLMDQDYISTPQMGTPVAANSAASTGNTGGVLPSPATPRFSVPTPRTPRTPRGVGTASGQGSVKHEGTEPGSPGSTPSTSRPLSSVEPLALPALPEAHSLYTVLLLSDSVLNIFKDRNFDSCCICACNMNVKGADVGLYIPDSTREDQYRCMCGFSAIINRRLAHGTGLFLEDELDIFGRGSEVARAAERQLALCRRTSPIGDPTAKRPQDPPSSVLVLLQEQCSRPISSLSSLHHPPTCSCHGRQGALLQSWAADKLWADGSDPCAECYNALVHGQQYVDNPAGGKVDQATVRSSALHSWPHTNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGSYGSEESPEPLPIPTLLLGYDRDFLALSPLALPFWEKLLLEPYGGQRDVAFLVVCPDSEALTTGARGFFRELSAVYETCRLGKHRPLAKVSRDGLVRVGTLDPQKLAEELVDEWFSEPWASEHDDDNLTKLKLYAHACRQQLAPQLAALSLDSSLLLPPKPQPPPPPPAAPPNLGSQSSAPPGGTTGPSATSTPSGATPGQGGAETPQGGAGDPENGQSTAPTPAPPAESQESCAERERIGIPTEAESADSHAHPPAIVLYVVDPFLCRAGGEEDEEAEPGSTWVLGLLRCYTDILQSLPESLQPALALQVVPCQYLLQPVSGESSHYIQHLRSLAFSTYSQCRRLLPTQTHIKSLTGFGPASIVHAVLKNPERPSPLQLYSPPFVLGPTRSKQLELGEAWGEGVPRYSVLFVGYCLSHDQRWILVSCTDQQGELLDTCIINIDVPNRARRTKVSARKMGLQKVWEWCIGIIQMTSLPWRVVIGRLGRLGHGELKDWSMLLGECALHSISRHLRDTCRMCGISASDSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNLQTSQLNTPQDASCTHILVFPTSATTQVAPGTYPTEDNPDDMFDLPFPDELENDIGNDMMLITGNLHPSPNSSPVPSPGSPSGMGGGSHFQHTRSQGERLLSRDAPEELKQQPLALGYYVSTAKAEDLPQWFWASCPQAQNQCPLFLKASLHHHISIAQTDDFISNKTSQRTPHPLDSKTTSDVLRFVLEQYNALSWLTCSPATQDRRSCLPVHFAVLTQMYNAILNML
Length2117
PositionMiddle
OrganismLepisosteus oculatus (Spotted gar)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Holostei> Semionotiformes> Lepisosteidae> Lepisosteus.
Aromaticity0.07
Grand average of hydropathy-0.392
Instability index58.98
Isoelectric point5.63
Molecular weight230812.47
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33681
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.71|      32|      36|     507|     541|       1
---------------------------------------------------------------------------
  453-  519 (28.15/ 6.93)	APSKHKVADKPEKTEKQPKRlamtpfhhrlslsqeacleqdpasgqklglvalepPLDVLP.SCKFPK
  543-  575 (43.56/ 8.27)	LSPHPRMQDPEVLEPPVGLP...................................PCPEVPlGPRLPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     219.16|      35|      35|     809|     843|       2
---------------------------------------------------------------------------
  809-  843 (64.14/24.36)	P...YPP.TVADLQRMFPT...PPSLEQHPAFSPVMTY.RDAL
  847-  877 (43.99/14.33)	P....PP.GMAGAENHLGT...L.STAQLSEFK..MEV.EEGL
  880-  911 (44.42/14.55)	P...KPE.DIKDFSYVFCV...PP.VQLQLGCSMFAPL.RT..
  913-  952 (36.83/10.77)	PsqcLPPlKVPETCYYRPSwalPPKMEQLP.LPPHVPFtRD..
 1488- 1506 (29.77/ 7.26)	P...PPP...PAA.........PPNLGSQSSAPP.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     129.60|      34|      39|     971|    1004|       3
---------------------------------------------------------------------------
  990- 1026 (54.55/23.75)	GGVLPSPATPRFSVPTPRTPrTPRGVGTASGQGsvKH
 1507- 1535 (49.09/20.45)	GGT.....TGPSATSTPSGA.TPGQGGAETPQG..GA
 1954- 1976 (25.95/ 6.48)	..LHPSPN....SSPVP.SPgSPSGMGGGS.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     151.28|      37|      39|     363|     400|       4
---------------------------------------------------------------------------
  325-  370 (50.89/31.72)	QPC.TDDTGFQTTVSS.SPGQEGGICTTTPSpkhsgrklsNQAlHQAW
  371-  411 (59.13/33.39)	KECYLNKTHHKRTLSG.SMTPEEEVPNSVPT.....wdfiDQA.QRAP
  412-  442 (41.26/20.22)	CCCSRHKSQKQRQMSAlGRPPANSQPGANPT.................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.66|      14|     206|     310|     323|       5
---------------------------------------------------------------------------
  310-  323 (27.50/14.84)	PSNASVPLTP...PTSP
  522-  538 (23.16/10.86)	PATGKVPDSPvhsPVSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     186.17|      36|     206|    1031|    1075|       6
---------------------------------------------------------------------------
 1031- 1066 (64.81/26.95)	PGSPGSTPSTSRPLSSVEPLALPALPEAHSLYTVLL
 1160- 1181 (31.41/ 8.45)	..SPIGDPTAKR..........PQDPPSSVL..VLL
 1183- 1211 (43.61/16.12)	.......EQCSRPISSLSSLHHPPTCSCHGRQGALL
 1244- 1273 (46.34/21.37)	PAGGKVDQATVR..SS....ALHSWPHTNVLDISML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.44|      22|     235|     716|     750|       9
---------------------------------------------------------------------------
  732-  765 (26.01/30.15)	STAPKSDDSRQDSAAAKanpsltretdlvVLISD
  780-  803 (34.43/13.21)	TTSPTRQSTRAPAAGAE..........drPLGKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.87|      18|     241|    1563|    1596|      12
---------------------------------------------------------------------------
  576-  593 (31.92/ 6.79)	PSESTLYVAPLSFSEAGG
 1579- 1596 (34.95/36.02)	PPAIVLYVVDPFLCRAGG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33681 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CCCSRHKSQKQRQMSALGRPPANSQPGANPTPPAAPSLPPPAPSKHKVADKPEKTEKQPKRLAMTPFHHRLSLSQEACLEQDPASGQKLGLVAL
2) DQDYISTPQMGTPVAANSAASTGNTGGVLPSPATPRFSVPTPRTPRTPRGVGTASGQGSVKHEGTEPGSPGSTPSTSRPLSSVEP
3) FDNSDEDELGTTSPTRQSTRAPAAGAEDRPLGKDGRTTVPYPPTVADLQRMFPTPPSLEQHPAFSPVMTYRDALSAEPPPGMAGAENHLGTL
4) GNDMMLITGNLHPSPNSSPVPSPGSPSGMGGGSHFQHTRSQGERLLSRDAPE
5) LSLDSSLLLPPKPQPPPPPPAAPPNLGSQSSAPPGGTTGPSATSTPSGATPGQGGAETPQGGAGDPENGQSTAPTPAPPAESQESCAERERIGIPTEAESADSHAHP
6) PSCKFPKPLPATGKVPDSPVHSPVSPLPPTLSPHPRMQDPEVLEPPVGLPPCPEVPLGPRLPEP
7) QAPTVSGSQGATRDPSNASVPLTPPTSPEQPCTDDTGFQTTVSSSPGQEGGICTTTPSPKHSGRKLSN
8) VGQERDPCRKVKGEEMTSGNSNPVPDGKDAMSIFSTAPKSDDSRQDSAAAKANPSLTRETD
412
965
770
1944
1473
513
296
698
505
1049
861
1995
1579
576
363
758










Molecular Recognition Features






MoRF SequenceStartStop




1) WWKGY
595
599