<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33680

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSGGPAVRVSIESACEKQVQEVSLDGIETYVQPLSMSQNLAKLAQRIDFGQGSDSEDEGGEGESRDQEWGKQEAEEDEATVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSVVKEKKYMTLDPVSHDVTAGKTPQVLQLIGKKKSLATAAQLLLKGAEKLSKSVAENQENRRQRDFNSELLRLRSQWKLRKVGDKILGDLSYKSAGSLFPHHGTFEVIKNTDIDLDKKIPDDYCPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVSLFRRQPKAKSGSQPWHAKLEAAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPFPGLQLSISLCHSTGEKKNQKASPEKSKPDDHLYVLEHNLHQLMREFHKQTLSSAVMPHPASAPFGHKRLRLAGPMAFDKAEIASLQQNEGLLEKIIKQAKHIFLRRRTARTIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQIRVVHRDGRVITLSHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWHVLSFSNHVGLGSVESIGNASAITVASPNGEFAISVRNGPESGCKVIVQFPRSQCKDLPKSDVIQDNKWNHLRGPSKEVHWNKMEGRNFVYKMELLMAALTPCP
Length643
PositionHead
OrganismLepisosteus oculatus (Spotted gar)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Holostei> Semionotiformes> Lepisosteidae> Lepisosteus.
Aromaticity0.06
Grand average of hydropathy-0.457
Instability index51.29
Isoelectric point8.21
Molecular weight71924.18
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33680
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.49|      22|     125|     213|     234|       1
---------------------------------------------------------------------------
  213-  234 (37.54/20.66)	HGTFEVIKNTDIDLDKKIPDDY
  242-  261 (26.92/13.03)	PSDLEGSAYIKVSIQKQAPD..
  340-  360 (38.03/21.01)	HSTGE.KKNQKASPEKSKPDDH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.32|      10|      26|     109|     118|       3
---------------------------------------------------------------------------
  109-  118 (15.29/10.83)	DVLSVVKEKK
  136-  145 (16.04/11.76)	QVLQLIGKKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.28|      12|      26|     152|     163|       6
---------------------------------------------------------------------------
  152-  163 (19.27/12.26)	QLL.LKGAEKLSK
  180-  192 (17.01/ 9.92)	ELLrLRSQWKLRK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33680 with Med17 domain of Kingdom Metazoa
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