<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33679

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMEVPGPDSDWRSLAFRQKVVGQIEDAMRKAGTAHAKTSNDMENHVFMKAKSRDEYLSLVARLIIHFRDIRCSGRISFFSVADPMNALQNLTGGNQGGAASMGLGAHPQGMAALGQMLPGQPQPGSSGMTPHGIQASVLLQAQPRSILSLQMLQSRMQQQPQQIAQLQLQQQQVVRACQMPSQSQPQAVVPQGQIQAQQVPLSSLNQQHHLKLQAMQVKQALALAHVPVQEIQLTLEAFAGVFGPRYFVSSVSRALKPLHFPLEEHGATTSITSYSLTNQIPLRPVHTMSVVPLSSKMMSATMVRGGIQPRLPRVSPASTLPPNSSGLGGQQMPQGGMTMMSSPSPVQQVQTPQSMPPPPQPQPSPQPPSSQPNSVSSGPAPSPGGFLPSPSPQPSQSPVTARTPQNFGVPSPGPLNTPGNPNSVMSPASSSQTEEQQYLEKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPSTKQQYLCQPLLDVVMANIRSPVFNHSLYRTFAPAMTAIHGPPIMGPMIATRKRKYEDDEKQTIPNILQGEVARLNSKFLVNLDPSHCSNNGTVHLICKLDDKHLPSVPPLQLSIPADYPEQSPQWADDAQQYDANPFLQTVHRNMTSKLLQLPDKHSVTALLNTWAQSVKQACLSAA
Length694
PositionTail
OrganismLepisosteus oculatus (Spotted gar)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Holostei> Semionotiformes> Lepisosteidae> Lepisosteus.
Aromaticity0.04
Grand average of hydropathy-0.433
Instability index71.34
Isoelectric point9.52
Molecular weight75607.08
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33679
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     195.30|      28|      28|     357|     384|       1
---------------------------------------------------------------------------
  171-  192 (32.82/ 7.86)	QQVVRACQMPSQSQPQAVV......PQG
  309-  335 (44.75/13.41)	PRLPRVSPASTL.PPNSSGLGGQQMPQG
  358-  384 (51.83/16.70)	PPQPQPSPQPPSSQPNSVSSGPAPSPG.
  388-  406 (30.76/ 6.90)	...PSPSPQ.PSQSP.....VTARTPQN
  407-  430 (35.14/ 8.93)	FGVPSPGPLNTPGNPNSVMS.PASS...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.98|      18|      26|      83|     108|       2
---------------------------------------------------------------------------
   82-   99 (31.77/ 6.41)	DPMNAL.QNLTGGNQGGAA
  108-  126 (31.21/18.08)	QGMAALgQMLPGQPQPGSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     119.09|      25|      26|     469|     493|       3
---------------------------------------------------------------------------
  439-  461 (35.64/17.26)	LEKLKQLSKYI.EPLRRM.INKIDK
  469-  493 (40.99/20.99)	LSKMKSLLDILTDPSKRCPLKTLQK
  498-  521 (42.46/22.02)	LEKLKNDMAVPTPPPPPVP.STKQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.14|      15|      15|     139|     153|       4
---------------------------------------------------------------------------
  139-  153 (26.21/13.84)	LQAQPRSILSLQMLQ
  156-  170 (25.93/13.60)	MQQQPQQIAQLQLQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.59|      14|      15|     209|     222|       5
---------------------------------------------------------------------------
  209-  222 (22.86/15.34)	HLKLQAMQVK.QALA
  225-  239 (17.73/ 9.79)	HVPVQEIQLTlEAFA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33679 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LSSKMMSATMVRGGIQPRLPRVSPASTLPPNSSGLGGQQMPQGGMTMMSSPSPVQQVQTPQSMPPPPQPQPSPQPPSSQPNSVSSGPAPSPGGFLPSPSPQPSQSPVTARTPQNFGVPSPGPLNTPGNPNSVMSPASSSQTEEQQYLEKLKQ
293
444










Molecular Recognition Features






MoRF SequenceStartStop




NANANA