<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33678

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMEVPGPDSDWRSLAFRQKVVGQIEDAMRKAGTAHAKTSNDMENHVFMKAKSRDEYLSLVARLIIHFRDILWRDSGERLWTSSFLADPMNALQNLTGGNQGGAASMGLGAHPQGMAALGQMLPGQPQPGSSGMTPHGIQEVDLTWGGTVQGHVHKAYDSYVQGTISKQSGFQTMQLKPKYSRKRRRVQSNSSNLPTFESLFNVTCLQVPRRPQQWLSLHMWLPCHSPSVLLQAQPRSINLSLQMLQSRMQQQPQQIAQLQLQQQQVVRAWSLPFLYLHPTYTDAMSILPPSASLKPTPTAGPNQMPSQSQPQAVVPQGQIQAQQVPLSSLNQQHHLKLQAMQQALALAHSWAGNSSCNQSYYMSVVPLSSKMMSATMVRGGIQPRLPRVSPASTLPPNSSGLGGQQMPQGGMTMMSSPSPVQQVQTPQSMPPPPQPQPSPQPPSSQPNSVRSSSGPAPSPGGFLPSPSPQPSQSPVTARTPQNFGVPSPGPLNTPEGNPNSVMSPASSSQTEEQQYLEKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPSTKQQYLCQPLLDVVMANIRSPVFNHSLYRTFAPAMTAIHGPPIMGPMIATRKRKYEDDEKQTIPNILQGEVARLNSKFLVNLDPSHCSNNGTVHLICKLDDKHLPSVPPLQLSIPADYPEQSPQWADDAQQYDANPFLQTVHRNMTSKLLQLPDKHSVTALLNTWAQSVKQACLSAA
Length771
PositionTail
OrganismLepisosteus oculatus (Spotted gar)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Holostei> Semionotiformes> Lepisosteidae> Lepisosteus.
Aromaticity0.05
Grand average of hydropathy-0.535
Instability index76.82
Isoelectric point9.56
Molecular weight84768.06
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33678
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     340.49|      48|      48|     390|     437|       1
---------------------------------------------------------------------------
  255-  321 (43.70/11.39)	IAQlqlqqqqvvrawSLPflylhptytdamsilPPS..ASL..KPTPTAGPNQM....PS...Q......SQ.......PQAVV.PQG......QIQ.A
  325-  386 (41.65/10.51)	PLS............SL................NQQ..HHLKLQAMQQALALAHSwaGNSSCNQsyymsvVP......LSSKMM.SATmvrggiQPRlP
  390-  437 (95.43/33.68)	PAS............TLP...............PNS..SGLGGQQMPQGGMTMMS..SPSPVQQ......VQ......TPQSMP.PPP......QPQ.P
  441-  492 (59.32/18.12)	PPS............S.Q...............PNSvrSSSGPAPSP.GGF..LP..SPSP.QP......SQspvtarTPQNFGvPSP......GPL.N
  498-  540 (49.81/14.02)	PNS............VMS...............PAS..SSQTEEQQYLEKLKQLS.......KY......IE......PLRRMI.NKI......DKN.E
  554-  593 (50.59/14.36)	DIL............TDP...............SKR..CPLKTLQKCEIALEKLK..NDMA.........VP......TP...P.PPP......VP...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.11|      21|      47|      93|     113|       2
---------------------------------------------------------------------------
   93-  113 (38.75/16.12)	NLT.GGNQGGAASMGLGAHPQG
  120-  136 (33.40/13.05)	MLP.GQPQPGSSGMT....PHG
  141-  162 (31.97/12.22)	DLTwGGTVQGHVHKAYDSYVQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.97|      18|     124|     597|     614|       4
---------------------------------------------------------------------------
  597-  614 (33.50/21.23)	QQYLCQPLLDVVMANIRS
  724-  741 (34.47/22.07)	QQYDANPFLQTVHRNMTS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33678 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ILPPSASLKPTPTAGPNQMPSQSQPQAVVPQGQIQ
2) MSATMVRGGIQPRLPRVSPASTLPPNSSGLGGQQMPQGGMTMMSSPSPVQQVQTPQSMPPPPQPQPSPQPPSSQPNSVRSSSGPAPSPGGFLPSPSPQPSQSPVTARTPQNFGVPSPGPLNTPEGNPNSVMSPASSSQTEEQQYLEKLKQ
286
372
320
521










Molecular Recognition Features






MoRF SequenceStartStop




NANANA