<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33677

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMEVPGPDSDWRSLAFRQKVVGQIEDAMRKAGTAHAKTSNDMENHVFMKAKSRDEYLSLVARLIIHFRDIHKKAQGPDPMNALQNLTGGNQGGAASMGLGAHPQGMAALGQMLPGQPQPGSSGMTPHGIQGPTQIHMQQMQQQQFHQYQTQQLHQQQQLHQQQQQMIKIQQMQQQQLQQQQLQQQNQQQQQQNQSQQMLQSRMQQQPQQIAQLQLQQQQQAAQQQQAQQQVQQSMHQAQHQPQAPSLQQQMQQMVQQQQQQQQQQQQQQQQQQQQQQQQQQQQQAAQQQPNQMPSQSQPQAVVPQGQIQAQQVPLSSLNQQHHLKLQAMQQALALAHKQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQAVAAQQAAQQQAAQQAQQVVQAQLTAGAPGQMMSATMVRGGIQPRLPRVSPASTLPPNSSGLGGQQMPQGGMTMMSSPSPVQQVQTPQSMPPPPQPQPSPQPPSSQPNSVSSGPAPSPGGFLPSPSPQPSQSPVTARTPQNFGVPSPGPLNTPGNPNSVMSPASSSQTEEQQYLEKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPSTKQQYLCQPLLDVVMANIRSPVFNHSLYRTFAPAMTAIHGPPIMGPMIATRKRKYEDDEKQTIPNILQGEVARLNSKFLVNLDPSHCSNNGTVHLICKLDDKHLPSVPPLQLSIPADYPEQSPQWADDAQQYDANPFLQTVHRNMTSKLLQLPDKHSVTALLNTWAQSVKQACLSAA
Length799
PositionTail
OrganismLepisosteus oculatus (Spotted gar)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Holostei> Semionotiformes> Lepisosteidae> Lepisosteus.
Aromaticity0.03
Grand average of hydropathy-0.977
Instability index87.70
Isoelectric point9.50
Molecular weight89166.37
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33677
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     594.25|      86|      86|     203|     288|       1
---------------------------------------------------------------------------
   74-  127 (71.97/ 6.42)	.QGPDPMNAL....QNLTGGNQ.GG....A.............ASMGLGAH.PQGMA.................ALGQ....M......LP.GQPQPGSSGMTPHG...................
  129-  201 (128.78/19.58)	.QGPTQI...HMQQMQ...QQQ.FHQYQTQ.............Q.LHQ...QQQ...LH..............QQQQQ....M......IKiQQMQQQQLQQQQLQQQNQQQQQQNQSQQMLQSR
  203-  288 (173.32/29.90)	QQQPQQIAQLQLQQQQQAAQQQ.QAQQQVQ.............QSMHQAQHQPQAPSLQ..............QQMQQ....M......VQ.QQQQQQQQQQQQQQQQQQQQQQQQQQQQAAQQQ
  290-  368 (137.42/21.58)	NQMPSQ.....SQPQAVVPQGQiQAQQVPL.............SSLNQ.QHHLKLQAMQ..............QALAL....A......HK.QQQQQQQQQQQQQQQQQQQQQQQQQQQQ..QQQ
  369-  476 (82.75/ 8.92)	QQ...AVAA.QQAAQQQAAQQ...AQQVVQaqltagapgqmmsATMVRGGIQPRLPRVSpastlppnssglggQQMPQggmtMmsspspVQ.QVQTPQSMPPPPQPQPSPQPPSSQ.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.61|      17|      28|     486|     511|       2
---------------------------------------------------------------------------
  486-  503 (32.53/ 9.77)	PSPGGfLPSP.SPQPSQSP
  515-  532 (32.09/14.79)	PSPGP.LNTPgNPNSVMSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.52|      15|      22|     663|     683|       3
---------------------------------------------------------------------------
  663-  677 (28.30/32.49)	PPIMGPMIATRKRKY
  686-  700 (25.23/11.01)	PNILQGEVARLNSKF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.66|      33|     126|     599|     642|       4
---------------------------------------------------------------------------
  610-  642 (61.83/37.50)	MAVPTPPPPPVP...STKQQYLCQPLLDVVMANIRS
  734-  769 (54.84/18.44)	LSIPADYPEQSPqwaDDAQQYDANPFLQTVHRNMTS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33677 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QQQQQQQQQAVAAQQAAQQQAAQQAQQVVQAQLTAGAPGQMMSATMVRGGIQPRLPRVSPASTLPPNSSGLGGQQMPQGGMTMMSSPSPVQQVQTPQSMPPPPQPQPSPQPPSSQPNSVSSGPAPSPGGFLPSPSPQPSQSPVTARTPQNFGVPSPGPLNTPGNPNSVMSPASSSQTEEQQYLEKLKQ
2) RDIHKKAQGPDPMNALQNLTGGNQGGAASMGLGAHPQGMAALGQMLPGQPQPGSSGMTPHGIQGPTQIHMQQMQQQQFHQYQTQQLHQQQ
362
67
549
156










Molecular Recognition Features






MoRF SequenceStartStop




NANANA