<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33671

Description Mediator of RNA polymerase II transcription subunit 8
SequenceMQQREEKQLEASIDALITRVAHLKNSLHSFIFKLENEYERLAWPSVLDNFALLSGQLNTINKLLKNEKTPVLRSQVIIPLLLSPDRDEELAKLTEQRVPVFSHEIVPDHLRTKPDPEVEEQEKQLNAEAVRIGPELAQKQIQTLNKLCSNLLEKLNNPREDRESESAALRQNKQTFNPTDTTALVAAVGFGKGLAKCRPPGSGGLVPPGQPGTGAMLQGGPTLQQVTMPGTSNPQAAIGGPVPQQQQGQPGKMPSNIKTNIKSASMHPYNR
Length271
PositionHead
OrganismLepisosteus oculatus (Spotted gar)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Holostei> Semionotiformes> Lepisosteidae> Lepisosteus.
Aromaticity0.03
Grand average of hydropathy-0.586
Instability index50.72
Isoelectric point8.48
Molecular weight29802.63
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IBA:GO_Central
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33671
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.55|      13|      18|     208|     225|       1
---------------------------------------------------------------------------
  208-  221 (24.12/ 9.21)	PGQPGTGAMLqGGP
  229-  241 (25.43/10.68)	PGTSNPQAAI.GGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.82|      11|      17|     116|     126|       2
---------------------------------------------------------------------------
  116-  126 (19.15/12.65)	PEVEEQEKQ.LN
  134-  145 (14.67/ 7.98)	PELAQKQIQtLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.14|      25|      27|      53|      79|       3
---------------------------------------------------------------------------
   53-   79 (33.07/25.77)	LSGQLNT.INKlLKNEKTPVLrSQVIIP
   82-  107 (39.07/21.45)	LSPDRDEeLAK.LTEQRVPVF.SHEIVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.05|      18|      18|     168|     185|       4
---------------------------------------------------------------------------
  168-  185 (30.20/17.86)	ALRQNK..QTFNPTDTTALV
  187-  206 (27.85/15.96)	AVGFGKglAKCRPPGSGGLV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33671 with Med8 domain of Kingdom Metazoa
Unable to open file!