<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33668

Description Mediator of RNA polymerase II transcription subunit 13
SequenceRMSSCFVPNGASLEDCHSNLFCLADLTGIKWKKYVWQGPTSAPILFPVTEEDPILCSFSRCLKADVLSVWRRHQTAGRRELWLFWWGEDPNFAELIHHELTGEEEGAWESGLSYECRTLLFKAIHNLLERCLMNRSFVRIGKWFVKPYEKDEKPINKSEHLSCAFTFFLHGDSNVCTSVEINQHQPIYHLSEGHLTLAQQSNSPFQVILSPFGLNGTLTGQSFKLSDPPTQKLIEEWKQFYPISPSSKESSEDKPDDMDWEDDSLAAVEVLVAGVRMVYPACLVLVPQSDIPAVTPVGSSHCTAVYSGVHQVPASTRDPAISSVTLTPPTSPEEAQTMDSQSAQKWVKFSSVSDGFSTDSTSHHGGKIPRKLASQVVDRVWQECNINRAQNKRKFSATTNGTCEEESTDKAGSWDFVDPTQRSNCNCSRHKNLKQRAGSTPGQPQAAGQPPQPPPKHKAVEKPEKGEKQQKRPLTPFHHRTSICEDVSMEPDATGQRLGMRAQDGGEPLKNPATPHSQHFYQPAPEPCLVPQKPAEDPRLDPLAQPFPPAYSEAMEPTVYVGAAVSPDEDNAHAPWKFFILPRKKDSDFAPPQLPGDKLRDDLPGTGSQESVVSVTELMATSKNPLKVSEGLVQMYIQRRTQYLSAAISDSDHEPELDPYAFVDGDVEFSFRDKKDKQGGEREAGKKHKADDGSNGGPVPAEGEDAMSLFSPSAKTEDAQRSAAHNRTASTSLMHENDLAVSINDLDNLFNSDEDELAPGARRAVNGTDEKFGNKEAKPASLDQLSCISSADLHQMFPTPPSLEQHIMGYSPMNMNSKEYGSLDNASGMTVLDGSSVLGGQFKIEVEEGFCSPKPSEIKDFSFVYKPEGCQAFVGCSMFAPLKTLPSQCLPPIKLPEECLYRPSWTVGKLELLNPVPALTFLNKDGNIPSVGSAMDQDYIQTYTPQTHTPFMSNSAPPSNGGTGILPSPATPRFSAPTPRTPRTPRTPRGPASVQGSLKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCVCVCNMNIKGADVGVYIPDPNCEVQYSCTCGFSAVMNRRYGNGSGLFLEDELDIIGRGSDASREVEKRFEAVHGSGASAERAGSLRDQVPDDLILLLQDQCTNPFSPITAPEPDSAPARGPGAPPPCVRVEERDCYSDCYLALEHGRQFMDNMSGGKVDEALVKSTCLHHWAKRNAVDVSMLCSQDVLRVLLSLQPVLQDAIQKKRTVRSWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLVGYEYDFVVLSPFGLPYWEKLLLDPFGSQRDVGYLVLCPENEALLSGAKGFFRDLTAVYESCRLGQHRPISKTHPDGIVRVGTAAAKKLADQPVSDWFLKAASSNSDSFAKLKLYAQVCRHDLAPYLAAQSLDSSLLVQPSPPPASSQSSSTPAPVVSAPGSQGTLTSSGTMTATAGTAIPPSASGTPSSTLPSSGPVGMGSSLQSSKPSSFPPFGNMGAQSGSSQSGTLGQQAGTQAPGITGENVPGAAQTQGPAEPPESTMEREKVGVPTDGDSHAITYPPAIVVYIVDPFTYEEMEGGAQSSSVWTLGLLRCYLEMLQSLPPHIRNAVSVQIIPCQYLLQPVKNDERHIYAQHLKSLAFSVFSQCRRPLPISTNVKTLTGFGPGLALDTALKSPERPECLRLYTPPFILAPVKDKQTELGETFGEASQKYNVLFVGYCLSHDQKWLLATCTDLYGELLETCIINIDVPNRARRKKGSARRLGLQKLWEWCLGLVQMTSLPWRVVIGRLGRIGHGELRDWSILLSRRNLQSLSRRLKEMCRMCGISAADTPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSAFVQVANSNYTTENIDIAFNPINDGSDGMGIFDLLDTGEDLVDPDIINILPASPTTSPVHSPGSHYPHGGDGSKGQSTDRLESHEEAPNILQQPLALGYFVSTAKAGPLPDWFWAACPQAQNQCPLFLKASLHLHVSSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPATQDRRSCLPIHFVVLNQMYNFIMNML
Length2122
PositionMiddle
OrganismLepisosteus oculatus (Spotted gar)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Holostei> Semionotiformes> Lepisosteidae> Lepisosteus.
Aromaticity0.07
Grand average of hydropathy-0.382
Instability index54.49
Isoelectric point5.49
Molecular weight231719.65
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33668
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    1084.27|     248|     263|     664|     925|       1
---------------------------------------------------------------------------
  676-  890 (329.27/174.94)	...............................................................DKQGGE.....REAGKKH.....KADDG..SNGG....P.VPAEGEDAMSLFS.PSAKTEDAQRSAAHNRTASTSLMH...EN.DL..AVSI...NDLDNLFNSDEDELAP.GARRA....VN.G..TDEK..FGNKEAKPASLDQLSCISSADLH..QMFPTPP..SLEQHIMG.Y.......SPMNMNSKE......YGSLDNASG.MTVL..DGSSVLGGQ..FkIEVEE...GFCSPKPSEI.KDFSFVYkPEGCQAFVGCSMF..AP...L.KTLPSQCL
  891- 1160 (316.98/151.25)	P..PIKLPEECLYRPSW..........TVGKLELLNPV......PALTFLNKDgnipsvgsamDQDYIQ.....TYTPQTHtpfmsNSAPP..SNGGtgilP.SPATPR.....FSaPTPRTPRTPRTPRGPASVQGSLKY...ENsDLysPAST...PSTCRPLNSVEPATVP.SIPEAhslyVNlI..LSES..VMN.LFKDCNFDS.CCVCVCNM............NIKGADVGvY.......IPDPNCEVQ......YSCTCGFSAvMNRR..YGNG..SGL..F.LEDELdiiGRGSDASREVeKRFEAVH.GSGASAERAGSLRdqVPddlI.LLLQDQCT
 1162- 1383 (255.16/120.12)	PfsPITAPEP.DSAPAR..........GPG.....APP......PCVRVEERD......................................cySDCY....L.ALEHGRQFMDNMS..GGKVDEAL.......VKSTCLHHwakRN.AV..DVSMlcsQDVLRVLLS....LQP.VLQDA....IQ.KkrTVRS..WGVQ..GPLTWQQFHKMAGRGSYgtDESPEPL..PIPTFLVG.YeydfvvlSPFGLPYWEkllldpFGSQRDV.G.YLVLcpENEALLSGAkgF..................F.RDLTAVY..ESCR..LG..QH..RP...IsKTHPDGIV
 1389- 1581 (182.86/83.32)	A..AKKLADQPV..SDWflkaassnsdSFAKLKLYAQVcrhdlaPYLAAQSLD................ssllvQPSPPPA.....SSQSS..STPA....PvVSAPGSQG.TLTS.SGTMTATAGTAIPPSASGTPSSTL...PS.SG..PVGM...G..SSLQSSKPSSFPPfGNMGA....QS.G..SSQSgtLGQQAGTQAPGITGENVPGAAQT..QGPAEPPesTMEREKVG.V........PTDGDSH.............................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.23|      44|     120|     294|     339|       2
---------------------------------------------------------------------------
  294-  339 (70.97/36.98)	VTPVGSSHCT.AVYSGVHQVPASTrdPAISSVTLTPPTSPEEAQTMD
  417-  461 (75.26/34.37)	VDPTQRSNCNcSRHKNLKQRAGST..PGQPQAAGQPPQPPPKHKAVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     296.53|      72|    1112|     476|     552|       3
---------------------------------------------------------------------------
  476-  549 (121.67/72.01)	........PFHH..rtSICE...DVSME.PDATGQ...RLG.MRAQDgGEPLKN.PATPHSQHFYQPAPEPCLVPQKPAEDPRLDPLAQPFPP
 1588- 1663 (88.80/44.29)	AivvyivdPFTY.......E...E..ME.GGAQSSsvwTLGlLRCY..LEMLQSlP..PHIRNAVSVQIIPCQYLLQPVKNDERHIYAQHLKS
 1665- 1732 (86.06/45.51)	A...........fsvfSQCRrplPISTNvKTLTGF...GPG.L.ALD..TALKS.PERPECLRLYTP...PFIL..APVKDKQTE.LGETFGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.33|      18|    1633|     353|     392|       5
---------------------------------------------------------------------------
  373-  392 (28.97/32.87)	ASQVVDRVWQECniNRAQNK
 2022- 2039 (38.36/ 8.07)	AGPLPDWFWAAC..PQAQNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.70|      26|    1633|      61|      86|       6
---------------------------------------------------------------------------
   61-   86 (52.90/38.42)	C.LKADVLSVWRRHQTAGRR.ELWLFW.W
 1768- 1796 (36.80/24.16)	CiINIDVPNRARRKKGSARRlGLQKLWeW
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33668 with Med13 domain of Kingdom Metazoa
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